Zobrazeno 1 - 10
of 779
pro vyhledávání: '"Hitoshi WATANABE"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract In this study, the fraction extracted from turmeric powder with 50% ethanol and fractionated with n-hexane were administered to diet-induced NASH model rats. NASH model was prepared with SD rats by feeding an originally designed choline-defi
Externí odkaz:
https://doaj.org/article/8b14def181ea42c8bff0c547b7e1280c
Autor:
Hitoshi Watanabe, Shun-Ichiro Asahara, Jinsook Son, Wendy M McKimpson, Rafael de Cabo, Domenico Accili
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0297555 (2024)
Diabetes mellitus is characterized by insulin resistance and β-cell failure. The latter involves impaired insulin secretion and β-cell dedifferentiation. Sulfonylurea (SU) is used to improve insulin secretion in diabetes, but it suffers from second
Externí odkaz:
https://doaj.org/article/d0a49fa61ced4d02b766a55aabd51715
Autor:
Yuka Inaba, Emi Hashiuchi, Hitoshi Watanabe, Kumi Kimura, Yu Oshima, Kohsuke Tsuchiya, Shin Murai, Chiaki Takahashi, Michihiro Matsumoto, Shigetaka Kitajima, Yasuhiko Yamamoto, Masao Honda, Shun-ichiro Asahara, Kim Ravnskjaer, Shin-ichi Horike, Shuichi Kaneko, Masato Kasuga, Hiroyasu Nakano, Kenichi Harada, Hiroshi Inoue
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Aggravation of liver steatosis shifts the hepatocellular death mode from apoptosis to necroptosis in acute and chronic liver damage. Here the authors report that the transcription factor ATF3 regulates this shift through the induction of RIPK3, a reg
Externí odkaz:
https://doaj.org/article/6e96d9a1b7674a218452a1194f8c9e95
Autor:
Tomoko Ohshima, Yoko Mukai, Hitoshi Watanabe, Keijiro Ohshima, Koichi Makimura, Takashi Komabayashi, Chul Ahn, Karen Meyer, Nobuko Maeda
Publikováno v:
Microorganisms, Vol 12, Iss 3, p 525 (2024)
Introduction: Candida dubliniensis was reclassified from the C. albicans genotype D, and reports show its frequent detection in HIV-positive individuals and easy acquisition of antifungal drug resistance. However, the oral carriage rate in healthy pe
Externí odkaz:
https://doaj.org/article/39c968b5aee14833b0e112e85226ed14
Autor:
Wen Du, Junqiang Wang, Taiyi Kuo, Liheng Wang, Wendy M. McKimpson, Jinsook Son, Hitoshi Watanabe, Takumi Kitamoto, Yunkyoung Lee, Remi J. Creusot, Lloyd E. Ratner, Kasi McCune, Ya-Wen Chen, Brendan H. Grubbs, Matthew E. Thornton, Jason Fan, Nishat Sultana, Bryan S. Diaz, Iyshwarya Balasubramanian, Nan Gao, Sandro Belvedere, Domenico Accili
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 24 (2022)
As a highly regenerative organ, the intestine is a promising source for cellular reprogramming for replacing lost pancreatic β cells in diabetes. Gut enterochromaffin cells can be converted to insulin-producing cells by forkhead box O1 (FoxO1) ablat
Externí odkaz:
https://doaj.org/article/6174ce1f4c8746e499f9f6f5c41100df
Autor:
Takumi Kitamoto, Yun-Kyoung Lee, Nishat Sultana, Hitoshi Watanabe, Wendy M. McKimpson, Wen Du, Jason Fan, Bryan Diaz, Hua V. Lin, Rudolph L. Leibel, Sandro Belvedere, Domenico Accili
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101624- (2022)
Objective: Lifelong insulin replacement remains the mainstay of type 1 diabetes treatment. Genetic FoxO1 ablation promotes enteroendocrine cell (EECs) conversion into glucose-responsive β-like cells. Here, we tested whether chemical FoxO1 inhibitors
Externí odkaz:
https://doaj.org/article/df93c47e5c174cc68dabf3af76c69142
Autor:
Kumi Kimura, Yuka Inaba, Hitoshi Watanabe, Toshiya Matsukawa, Michihiro Matsumoto, Hiroshi Inoue
Publikováno v:
Journal of Diabetes Investigation, Vol 10, Iss 3, Pp 659-666 (2019)
Abstract Aims/Introduction Non‐alcoholic steatohepatitis (NASH), which occurs in association with insulin resistance and hepatic fat accumulation, is characterized by chronic liver injury and fibrosis. NASH onset and progression is closely related
Externí odkaz:
https://doaj.org/article/b96096c9bd3444dbacf8665450886b42
Autor:
Takeshi Kimura, Tomonori Sano, Kazuto Hayashida, Naohiro Takeichi, Yoshikazu Minegishi, Yoshiyuki Yoshida, Hitoshi Watanabe
Publikováno v:
Japan Architectural Review, Vol 2, Iss 1, Pp 101-110 (2019)
Abstract SimTread was developed as a pedestrian simulation system following a straightforward, highly user‐definable pedestrian and spatial model. Unlike network and mesh models, this pedestrian model is a multi‐agent system in which an individua
Externí odkaz:
https://doaj.org/article/af09859ea86442c1be07b034b8165d65
Publikováno v:
Biomolecules, Vol 12, Iss 5, p 614 (2022)
Pancreatic β-cells are the only type of cells that can control glycemic levels via insulin secretion. Thus, to explore the mechanisms underlying pancreatic β-cell failure, many reports have clarified the roles of important molecules, such as the me
Externí odkaz:
https://doaj.org/article/0e5a98fb9d5e437fa080836ec412d4af
Autor:
Ryutaro Iwasaki, Masaaki Sakamoto, Tomoyuki Rokkaku, Hitoshi Watanabe, Toshiyuki Yamada, Takeshi Yamaguchi, Yasushi Wako, Hitoshi Kubosawa, Seiji Ohtori
Publikováno v:
Case Reports in Orthopedics, Vol 2020 (2020)
The present report describes an incomplete atypical femoral fracture (AFF) patient who underwent simultaneous autogenous bone transplantation to the resected fracture region during intramedullary nail fixation. A 73-year-old female with a history of
Externí odkaz:
https://doaj.org/article/e6e5497dffa5425b8503194090436770