Topical application of activator protein-1 inhibitor T-5224 suppresses inflammation and improves skin barrier function in a murine atopic dermatitis-like dermatitis

Autor: Minori Sasakura, Hitoshi Urakami, Kota Tachibana, Kenta Ikeda, Ken-ichi Hasui, Yoshihiro Matsuda, Ko Sunagawa, Daisuke Ennishi, Shuta Tomida, Shin Morizane

Publikováno v: Allergology International, Vol 73, Iss 2, Pp 323-331 (2024)

Background: Selective activator protein (AP)-1 inhibitors are potentially promising therapeutic agents for atopic dermatitis (AD) because AP-1 is an important regulator of skin inflammation. However, few studies have investigated the effect of topica

Externí odkaz: https://doaj.org/article/06af282f393d4c32886f22e0df120beb

A Case of Basal Cell Carcinoma with Distant Metastasis to Bone and Lung

Autor: Hitoshi URAKAMI, Tatsuya KAJI, Osamu YAMASAKI, Kiyoshi YAMADA, Kazuhiko KUROZUMI, Toshiyuki KUNISADA, Masahiro TABATA, Shin MORIZANE

Publikováno v: Nishi Nihon Hifuka. 84:443-446

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc99d74058b6e5fe2e44cb76bfbe0fa7
https://doi.org/10.2336/nishinihonhifu.84.443

Multifaceted Analysis of IL-23A- and/or EBI3-Including Cytokines Produced by Psoriatic Keratinocytes

Autor: Fan Jiang, Shin Morizane, Hayato Nomura, Ai Kajita, Satoru Sugihara, Mina Kobashi, Hitoshi Urakami, Masakiyo Sakaguchi, Mamoru Ouchida, Kota Tachibana, Nina Tang, Nahoko Tomonobu, Minori Sasakura

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 12659, p 12659 (2021)
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12659

Interleukin (IL) 23 (p19/p40) plays a critical role in the pathogenesis of psoriasis and is upregulated in psoriasis skin lesions. In clinical practice, anti-IL-23Ap19 antibodies are highly effective against psoriasis. IL-39 (p19/ Epstein-Barr virus-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d7cef08d8c379ec44d0e22924468e13
http://europepmc.org/articles/PMC8657699