Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Hitoshi Takizawa"'
Autor:
Yuji Takihara, Takumi Higaki, Tomomasa Yokomizo, Terumasa Umemoto, Kazunori Ariyoshi, Michihiro Hashimoto, Maiko Sezaki, Hitoshi Takizawa, Toshihiro Inoue, Toshio Suda, Hidenobu Mizuno
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)
An intravital imaging method reveals the in vivo motile dynamics and colonization process of neonatal hematopoietic stem cells during bone marrow formation.
Externí odkaz:
https://doaj.org/article/b19549eaff0345ef8413e5e99a3aa9f9
Autor:
Yosuke Tanaka, Reina Takeda, Tsuyoshi Fukushima, Keiko Mikami, Shun Tsuchiya, Moe Tamura, Keito Adachi, Terumasa Umemoto, Shuhei Asada, Naoki Watanabe, Soji Morishita, Misa Imai, Masayoshi Nagata, Marito Araki, Hitoshi Takizawa, Tomofusa Fukuyama, Chrystelle Lamagna, Esteban S. Masuda, Ryoji Ito, Susumu Goyama, Norio Komatsu, Tomoiku Takaku, Toshio Kitamura
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Leukemic stem cells (LSCs) in chronic myeloid leukemia are resistant to imatinib and therefore are a cause of relapse. The authors show that IRAK1/4-NF-κB-PD-L1 signaling is critical to mediate imatinib resistance in LSCs and that combining imatinib
Externí odkaz:
https://doaj.org/article/c3477c962caf480e9537b3db7eabd49c
Autor:
Xiaoxiao Liu, Naru Sato, Tomohiro Yabushita, Jingmei Li, Yuhan Jia, Moe Tamura, Shuhei Asada, Takeshi Fujino, Tsuyoshi Fukushima, Taishi Yonezawa, Yosuke Tanaka, Tomofusa Fukuyama, Akiho Tsuchiya, Shiori Shikata, Hiroyuki Iwamura, Chieko Kinouchi, Kensuke Komatsu, Satoshi Yamasaki, Tatsuhiro Shibata, Atsuo T Sasaki, Janet Schibler, Mark Wunderlich, Eric O'Brien, Benjamin Mizukawa, James C Mulloy, Yuki Sugiura, Hitoshi Takizawa, Takuma Shibata, Kensuke Miyake, Toshio Kitamura, Susumu Goyama
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 1, Pp n/a-n/a (2023)
Abstract Inosine monophosphate dehydrogenase (IMPDH) is a rate‐limiting enzyme in de novo guanine nucleotide synthesis pathway. Although IMPDH inhibitors are widely used as effective immunosuppressants, their antitumor effects have not been proven
Externí odkaz:
https://doaj.org/article/80b4174013704cb29ecfb11251a79951
Autor:
Takanori Matsubara, Takayuki Yanagida, Noriaki Kawaguchi, Takashi Nakano, Junichiro Yoshimoto, Maiko Sezaki, Hitoshi Takizawa, Satoshi P. Tsunoda, Shin-ichiro Horigane, Shuhei Ueda, Sayaka Takemoto-Kimura, Hideki Kandori, Akihiro Yamanaka, Takayuki Yamashita
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Scintillators emit visible luminescence when irradiated with X-rays and may enable remote optogenetic control of neurons deep in the brain. The authors inject an inorganic scintillator to activate and inhibit midbrain dopamine neurons in freely movin
Externí odkaz:
https://doaj.org/article/30586a4d7471470ab7f1c8b1080aa23f
Autor:
Daisuke Suzuki, Charlotte Flahou, Norihide Yoshikawa, Ieva Stirblyte, Yoshikazu Hayashi, Akira Sawaguchi, Marina Akasaka, Sou Nakamura, Natsumi Higashi, Huaigeng Xu, Takuya Matsumoto, Kosuke Fujio, Markus G. Manz, Akitsu Hotta, Hitoshi Takizawa, Koji Eto, Naoshi Sugimoto
Publikováno v:
Stem Cell Reports, Vol 14, Iss 1, Pp 49-59 (2020)
Summary: The ex vivo production of platelets depleted of human leukocyte antigen class I (HLA-I) could serve as a universal measure to overcome platelet transfusion refractoriness caused by HLA-I incompatibility. Here, we developed human induced plur
Externí odkaz:
https://doaj.org/article/9f437e1b02f6488582832358c907a1bf
Autor:
Yasutaka Hayashi, Susumu Goyama, XiaoXiao Liu, Moe Tamura, Shuhei Asada, Yosuke Tanaka, Tomofusa Fukuyama, Mark Wunderlich, Eric O’Brien, Benjamin Mizukawa, Satoshi Yamazaki, Akiko Matsumoto, Satoshi Yamasaki, Tatsuhiro Shibata, Koichi Matsuda, Goro Sashida, Hitoshi Takizawa, Toshio Kitamura
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
MDM2 is frequently overexpressed in acute myeloid leukaemia leading to p53 inactivation. Here, the authors are demonstrating that an inhibitor of p53-MDM2 interaction, DS-5272, induce in vivo tumour regression through immune response regulation.
Externí odkaz:
https://doaj.org/article/ac8963cff5ca454687e5a94c4c01ac79
Autor:
Paul E. Bourgine, Kristin Fritsch, Sebastien Pigeot, Hitoshi Takizawa, Leo Kunz, Konstantinos D. Kokkaliaris, Daniel L. Coutu, Markus G. Manz, Ivan Martin, Timm Schroeder
Publikováno v:
iScience, Vol 19, Iss , Pp 504-513 (2019)
Summary: The generation of humanized ectopic ossicles (hOss) in mice has been proposed as an advanced translational and fundamental model to study the human hematopoietic system. The approach relies on the presence of human bone marrow-derived mesenc
Externí odkaz:
https://doaj.org/article/39459b785a5d449c90b0a2fcc03f214e
Fit-For-All iPSC-Derived Cell Therapies and Their Evaluation in Humanized Mice With NK Cell Immunity
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Human induced pluripotent stem cells (iPSCs) can be limitlessly expanded and differentiated into almost all cell types. Moreover, they are amenable to gene manipulation and, because they are established from somatic cells, can be established from ess
Externí odkaz:
https://doaj.org/article/f3bd6a56100842d582891b3b82d077d0
Autor:
Maiko Sezaki, Yoshikazu Hayashi, Yuxin Wang, Alban Johansson, Terumasa Umemoto, Hitoshi Takizawa
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Lifelong blood production is maintained by bone marrow (BM)-residing hematopoietic stem cells (HSCs) that are defined by two special properties: multipotency and self-renewal. Since dysregulation of either may lead to a differentiation block or exten
Externí odkaz:
https://doaj.org/article/df0673ca8e6647acb0db1e3281e0e4f3
Autor:
Takanori Matsubara, Takayuki Yanagida, Noriaki Kawaguchi, Takashi Nakano, Junichiro Yoshimoto, Maiko Sezaki, Hitoshi Takizawa, Satoshi P. Tsunoda, Shin-ichiro Horigane, Shuhei Ueda, Sayaka Takemoto-Kimura, Hideki Kandori, Akihiro Yamanaka, Takayuki Yamashita
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/76a975697486430a8dc4adfedf9f0986