Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Hitoshi Okochi"'
Autor:
Junko Nishida, Takahiro Tsuno, Shigeharu G. Yabe, Tatsuya Kin, Satsuki Fukuda, Fujie Takeda, Jun Shirakawa, Hitoshi Okochi
Publikováno v:
Endocrine Journal, Vol 71, Iss 3, Pp 253-264 (2023)
Maintenance of islet function after in vitro culture is crucial for both transplantation and research. Here we evaluated the effects of encapsulation in alginate fiber on the function of human islets which were distributed by the Alberta Islet Distri
Externí odkaz:
https://doaj.org/article/17d1b3ba3e4c4e2ebeddff52c66c992b
Autor:
Shoji Fukuda, Shotaro Hagiwara, Hitoshi Okochi, Nobuko Ishiura, Toshiya Nishibe, Ryo Yakabe, Hiroko Suzuki
Publikováno v:
Regenerative Therapy, Vol 24, Iss , Pp 472-478 (2023)
Introduction: The prevalence of diabetes mellitus is increasing globally, including in Japan. Patients with diabetes often experience microangiopathy and macroangiopathy, which lead to difficult-to-treat foot ulcers and diabetic gangrene. Conventiona
Externí odkaz:
https://doaj.org/article/73b7e41880d840a7a7cac59a46067215
Publikováno v:
Heliyon, Vol 9, Iss 9, Pp e19972- (2023)
Human pluripotent stem cell (hPSCs) derived-pancreatic islets (hSC-islets) are good candidates for cell replacement therapy for patients with diabetes as substitutes for deceased donor-derived islets, because they are pluripotent and have infinite pr
Externí odkaz:
https://doaj.org/article/94e313e7153e43bba8c48f4456bb467d
Autor:
Nobuyo Higashi-Kuwata, Shigeharu G. Yabe, Satsuki Fukuda, Junko Nishida, Miwa Tamura-Nakano, Shin-ichiro Hattori, Hitoshi Okochi, Hiroaki Mitsuya
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 6 (2022)
ABSTRACT We newly generated two human induced pluripotent stem cell (hiPSC)-derived spheroid lines, termed Spheroids_4MACE2-TMPRSS2 and Spheroids_15M63ACE2-TMPRSS2, both of which express angiotensin-converting enzyme 2 (ACE2) and transmembrane protea
Externí odkaz:
https://doaj.org/article/4874bf3d73fb442ab684163c2d36e7b3
Autor:
Satsuki Fukuda, Shigeharu G. Yabe, Junko Nishida, Fujie Takeda, Kiyoko Nashiro, Hitoshi Okochi
Publikováno v:
Regenerative Therapy, Vol 11, Iss , Pp 65-72 (2019)
Introduction: Although immunosuppressants are required for current islet transplantation for type 1 diabetic patients, many papers have already reported encapsulation devices for islets to avoid immunological attack. The aim of this study is to deter
Externí odkaz:
https://doaj.org/article/ed2a5984737440059d86d9424d20b76c
Autor:
Marie Shinohara, Hyunjin Choi, Masato Ibuki, Shigeharu G. Yabe, Hitoshi Okochi, Atsushi Miyajima, Yasuyuki Sakai
Publikováno v:
Regenerative Therapy, Vol 12, Iss , Pp 14-19 (2019)
A differentiation of human induced pluripotent stem cells (hiPSCs) into definitive endoderm linage is required for a preparation of metabolic organ derived cells. The differentiation consumed high-priced cytokines and small molecules, which have hamp
Externí odkaz:
https://doaj.org/article/35d27136ce874b4d870ceb04ee8de67e
Autor:
Shigeharu G. Yabe, Satsuki Fukuda, Junko Nishida, Fujie Takeda, Kiyoko Nashiro, Hitoshi Okochi
Publikováno v:
Regenerative Therapy, Vol 10, Iss , Pp 69-76 (2019)
Introduction: To complement islet transplantation for type1 diabetic patients, cell-based therapy using pluripotent stem cells such as ES cells and iPS cells is promising. Many papers have already reported the induction of pancreatic β cells from th
Externí odkaz:
https://doaj.org/article/aab07e3502bd463ab4b2436c7962b1f5
Publikováno v:
iScience, Vol 24, Iss 4, Pp 102309- (2021)
Summary: Cell therapy using human-stem-cell-derived pancreatic beta cells (hSC-βs) is a potential treatment method for type 1 diabetes mellitus (T1D). For therapeutic safety, hSC-βs need encapsulation in grafts that are scalable and retrievable. In
Externí odkaz:
https://doaj.org/article/48fffb5566964baea2ae0af975453d4a
Autor:
Shigeharu G Yabe, Satsuki Fukuda, Junko Nishida, Fujie Takeda, Kiyoko Nashiro, Hitoshi Okochi
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0245204 (2021)
Diabetes mellitus is caused by breakdown of blood glucose homeostasis, which is maintained by an exquisite balance between insulin and glucagon produced respectively by pancreatic beta cells and alpha cells. However, little is known about the mechani
Externí odkaz:
https://doaj.org/article/ae2a49174858477e8c88ab1a775e4ca2
Autor:
Shigeharu G Yabe, Junko Nishida, Satsuki Fukuda, Fujie Takeda, Kiyoko Nasiro, Kazuki Yasuda, Naoko Iwasaki, Hitoshi Okochi
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0217110 (2019)
Maturity-onset diabetes of the young (MODY) is a heterozygous monogenic diabetes; more than 14 disease genes have been identified. However, the pathogenesis of MODY is not fully understood because the patients' pancreatic beta cells are inaccessible.
Externí odkaz:
https://doaj.org/article/7a4ce2c7caaa4c518abc84673088aaa0