Zobrazeno 1 - 10
of 337
pro vyhledávání: '"Hitoshi NAKAGAMA"'
Autor:
Hiroshi Igaki, Satoshi Nakamura, Naoya Yamazaki, Tomoya Kaneda, Mihiro Takemori, Tairo Kashihara, Naoya Murakami, Kenjiro Namikawa, Tetsu Nakaichi, Hiroyuki Okamoto, Kotaro Iijima, Takahito Chiba, Hiroki Nakayama, Ayaka Nagao, Madoka Sakuramachi, Kana Takahashi, Koji Inaba, Kae Okuma, Yuko Nakayama, Kazuaki Shimada, Hitoshi Nakagama, Jun Itami
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
This study reports the first patient treatment for cutaneous malignant melanoma using a linear accelerator-based boron neutron capture therapy (BNCT) system. A single-center open-label phase I clinical trial had been conducted using the system since
Externí odkaz:
https://doaj.org/article/c1a4c84fee7c4fe6bf99af8f0c0f21a7
Autor:
Hiroshi Igaki, Naoya Murakami, Satoshi Nakamura, Naoya Yamazaki, Tairo Kashihara, Akira Takahashi, Kenjiro Namikawa, Mihiro Takemori, Hiroyuki Okamoto, Kotaro Iijima, Takahito Chiba, Hiroki Nakayama, Ayaka Takahashi, Tomoya Kaneda, Kana Takahashi, Koji Inaba, Kae Okuma, Yuko Nakayama, Kazuaki Shimada, Hitoshi Nakagama, Jun Itami
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 33, Iss , Pp 128-133 (2022)
Purpose: This study reports the first-in-human use of a linear accelerator-based boron neutron capture therapy (BNCT) system and the first treatment of patients with scalp-angiosarcoma with accelerator-based BNCT. Patients and methods: A single-cente
Externí odkaz:
https://doaj.org/article/d1594e222ff5484c9e8c0d168c93f61c
Publikováno v:
Genes and Environment, Vol 42, Iss 1, Pp 1-10 (2020)
Abstract Background DNA-dependent protein kinase (DNA-PK), consisting of a Ku heterodimer (Ku70/80) and a large catalytic subunit (DNA-PKcs), plays an important role in the repair of DNA double-strand breaks via non-homologous end-joining (NHEJ) in m
Externí odkaz:
https://doaj.org/article/4cf083ffaf264a8b9c53e04da9e67b0c
Autor:
Daisuke Shiokawa, Ai Sato, Hirokazu Ohata, Michihiro Mutoh, Shigeki Sekine, Mamoru Kato, Tatsuhiro Shibata, Hitoshi Nakagama, Koji Okamoto
Publikováno v:
Cell Reports, Vol 19, Iss 5, Pp 981-994 (2017)
Summary: The generation of tumor-initiating cells during colon carcinogenesis is associated with the dysregulation of Wnt signaling, which is known to act on Lgr5-positive intestinal stem cells. Here, using single-cell qPCR analysis, we identified a
Externí odkaz:
https://doaj.org/article/867bc2304372419293d3b5fa6f01005d
Autor:
Hirokazu Ohata, Daisuke Shiokawa, Yuuki Obata, Ai Sato, Hiroaki Sakai, Mayu Fukami, Wakako Hara, Hirokazu Taniguchi, Masaya Ono, Hitoshi Nakagama, Koji Okamoto
Publikováno v:
Cell Reports, Vol 28, Iss 5, Pp 1282-1295.e8 (2019)
Summary: Cancer stem cells (CSCs) are associated with the refractory nature of cancer, and elucidating the targetable pathways for CSCs is crucial for devising innovative antitumor therapies. We find that the proliferation of CSC-enriched colon spher
Externí odkaz:
https://doaj.org/article/a85122d0b35b4d98bd0630b88fc759df
Autor:
Yuko Atsumi, Yusuke Minakawa, Masaya Ono, Sachiko Dobashi, Keitaro Shinohe, Akira Shinohara, Shunichi Takeda, Masatoshi Takagi, Nobuhiko Takamatsu, Hitoshi Nakagama, Hirobumi Teraoka, Ken-ichi Yoshioka
Publikováno v:
Cell Reports, Vol 13, Iss 12, Pp 2728-2740 (2015)
In response to DNA double-strand breaks (DSBs), H2AX is rapidly phosphorylated at Ser139 to promote DSB repair. Here we show that H2AX is rapidly stabilized in response to DSBs to efficiently generate γH2AX foci. This mechanism operated even in quie
Externí odkaz:
https://doaj.org/article/4697a8942b394b649392661b5f8ba685
Autor:
Kousuke Ishino, Tatsuya Kato, Mamoru Kato, Tatsuhiro Shibata, Masatoshi Watanabe, Keiji Wakabayashi, Hitoshi Nakagama, Yukari Totsuka
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 2, Pp 3474-3492 (2015)
Nanosized-magnetite (MGT) is widely utilized in medicinal and industrial fields; however, its toxicological properties are not well documented. In our previous report, MGT showed genotoxicity in both in vitro and in vivo assay systems, and it was sug
Externí odkaz:
https://doaj.org/article/a5bf506180994b338498ac30579fb09f
Autor:
Chihiro Otsubo, Ryo Otomo, Makoto Miyazaki, Yuko Matsushima-Hibiya, Takashi Kohno, Reika Iwakawa, Fumitaka Takeshita, Hirokazu Okayama, Hitoshi Ichikawa, Hideyuki Saya, Tohru Kiyono, Takahiro Ochiya, Fumio Tashiro, Hitoshi Nakagama, Jun Yokota, Masato Enari
Publikováno v:
Cell Reports, Vol 7, Iss 2, Pp 527-538 (2014)
Summary: In lung cancer progression, p53 mutations are more often observed in invasive tumors than in noninvasive tumors, suggesting that p53 is involved in tumor invasion and metastasis. To understand the nature of p53 function as a tumor suppressor
Externí odkaz:
https://doaj.org/article/e73b97deeab04def8cdc0bfcc1c5e983
Autor:
Takahiro Kochi, Masahito Shimizu, Yukari Totsuka, Yohei Shirakami, Takayuki Nakanishi, Tetsushi Watanabe, Takuji Tanaka, Hitoshi Nakagama, Keiji Wakabayashi, Hisataka Moriwaki
Publikováno v:
Toxicology Reports, Vol 1, Iss C, Pp 69-73 (2014)
The benzoazepinoqunolinone derivative, 5-amino-6-hydroxy-8H-benzo[6,7]azepino[5,4,3-de]quinolin-7-one (ABAQ), which is produced in a mixture of glucose and tryptophan incubated at 37 °C under physiological conditions in the presence or absence of hy
Externí odkaz:
https://doaj.org/article/a5b465d976624acea86af21890986951
Autor:
Kazuhiro Kanemoto, Katsuhiro Fukuta, Noriyasu Kawai, Keiichi Tozawa, Masako Ochiai, Koji Okamoto, Sumiko Ohnami, Hiromi Sakamoto, Teruhiko Yoshida, Yae Kanai, Masaru Katoh, Takahiro Yasui, Kenjiro Kohri, Tadao Kakizoe, Hitoshi Nakagama
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0167374 (2016)
Non-muscle invasive (superficial) bladder cancer is a low-grade malignancy with good prognosis, while muscle invasive (invasive) bladder cancer is a high-grade malignancy with poor prognosis. N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) induces superf
Externí odkaz:
https://doaj.org/article/187ab9785a7143aebb75fac5dc782ffe