Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Hitoshi Kotani"'
Publikováno v:
Cancer Reports, Vol 7, Iss 4, Pp n/a-n/a (2024)
Abstract Introduction Gemcitabine (GEM) is often used to treat pancreatic cancer. Many anti‐cancer drugs induce cancer cell death, but some cells survive after cell cycle arrest. Such a response to DNA damage is termed cellular senescence. Certain
Externí odkaz:
https://doaj.org/article/4361c3d3eb3f44e6a06b7bd4b368f7e2
Publikováno v:
Cancer Medicine, Vol 10, Iss 24, Pp 8988-8999 (2021)
Abstract Inhibition of CDK4/6 slows the cell cycle and induces senescence in breast cancer cells. However, senescent cancer cells promote invasion and metastasis. Several drugs reportedly target senescent cells, including ABT‐263 (navitoclax). We e
Externí odkaz:
https://doaj.org/article/29f1e9650b1e40c1be705a97d505b947
Autor:
Misaki Watanabe, Tadahiro Yahagi, Takahiro Shirayama, Katsunori Miyake, Hitoshi Kotani, Takuya Ogawa, Keiichi Matsuzaki
Publikováno v:
Plants, Vol 11, Iss 16, p 2075 (2022)
We screened natural resources for estrogen receptor (ER)-activating and bone metabolism-promoting activities with the aim of finding potential treatments for osteoporosis. A screen of 1531 extracts from Ryukyu Arc plants using a luciferase reporter a
Externí odkaz:
https://doaj.org/article/731d2152a2e2416387d8e2fec696471e
Autor:
Go Muto, Hitoshi Kotani, Taisuke Kondo, Rimpei Morita, Sanae Tsuruta, Takashi Kobayashi, Hervé Luche, Hans Joerg Fehling, Matthew Walsh, Yongwon Choi, Akihiko Yoshimura
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74639 (2013)
Regulatory T cells (Tregs) maintain immune homeostasis by limiting inflammatory responses. TRAF6 plays a key role in the regulation of innate and adaptive immunity by mediating signals from various receptors including the T-cell receptor (TCR). T cel
Externí odkaz:
https://doaj.org/article/12e6f6f59c114f279f854912442d18c1
Autor:
Kartika, Irna D.1,2 haramamo@med.shimane-u.ac.jp, Hitoshi Kotani1, Yuichi Iida1, Akira Koyanagi1, Ryosuke Tanino3, Mamoru Harada1
Publikováno v:
Cancer Medicine. Dec2021, Vol. 10 Issue 24, p8988-8999. 12p.
Autor:
Mohammad Mahbubul, Hoque, Yuichi, Iida, Hitoshi, Kotani, Irna Diyana, Kartika, Mamoru, Harada
Publikováno v:
Anticancer Research. 42:3495-3506
Anti-apoptotic proteins, including Bcl-2 and Bcl-xL, hinder cancer treatment, and several drugs targeting these molecules have been developed. One is ABT-263 (navitoclax), which targets Bcl-2, Bcl-xL, and Bcl-w. On the other hand, hydroxychloroquine
Autor:
Yuichi Iida, Mamoru Harada, Akira Koyanagi, Hitoshi Kotani, Ryosuke Tanino, Irna Diyana Kartika
Publikováno v:
Cancer Medicine, Vol 10, Iss 24, Pp 8988-8999 (2021)
Cancer Medicine
Cancer Medicine
Inhibition of CDK4/6 slows the cell cycle and induces senescence in breast cancer cells. However, senescent cancer cells promote invasion and metastasis. Several drugs reportedly target senescent cells, including ABT‐263 (navitoclax). We examined t
Autor:
Takafumi Minami, Kazuhiro Yoshikawa, Masatoshi Eto, Hitoshi Kotani, Hirotsugu Uemura, Yuichi Iida, Mamoru Harada, Yoshihiro Komohara
Publikováno v:
Cancer Immunology, Immunotherapy. 71:339-352
Renal cell carcinoma (RCC) is known to respond to immune checkpoint blockade (ICB) therapy, whereas there has been limited analysis of T-cell responses to RCC. In this study, we utilized human carbonic anhydrase 9 (hCA9) as a model neoantigen of mous
Autor:
Akira Koyanagi, Hitoshi Kotani, Yuichi Iida, Ryosuke Tanino, Irna D. Kartika, Koji Kishimoto, Mamoru Harada
Publikováno v:
Cell Proliferation. 55
Autor:
Akira, Koyanagi, Hitoshi, Kotani, Yuichi, Iida, Ryosuke, Tanino, Irna D, Kartika, Koji, Kishimoto, Mamoru, Harada
Publikováno v:
Cell proliferation. 55(12)
Therapy-induced senescent cancer cells increase the expression of the cyclin-dependent kinase inhibitors p16Senescence was induced by doxorubicin (DXR) or pemetrexed (PEM). The protein expression of p21 was examined by immunoblot. Cell death, reactiv