Zobrazeno 1 - 10
of 237
pro vyhledávání: '"Hitoshi Kohsaka"'
Publikováno v:
Immunological Medicine, Vol 46, Iss 4, Pp 191-195 (2023)
AbstractA 56-year-old woman was treated for rheumatoid arthritis for 17 years with methotrexate (MTX). Night sweats, fever and weight loss made her visit our hospital. Although levofloxacin failed to resolve her fever, she was suspected of having sep
Externí odkaz:
https://doaj.org/article/219dccf91c724bc69ad7341f8c0cffdc
Autor:
Natsuka Umezawa, Fumitaka Mizoguchi, Yasuhiro Maejima, Naoki Kimura, Hisanori Hasegawa, Tadashi Hosoya, Minoru Fujimoto, Hitoshi Kohsaka, Tetsuji Naka, Shinsuke Yasuda
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
ObjectivesSerum levels of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) have been used as useful biomarkers for reflecting the activity of large vessel vasculitides (LVV). However, a novel biomarker that could have a complementary
Externí odkaz:
https://doaj.org/article/c4add4a40e3f430782da5f8606393b89
Autor:
Mari Kamiya, Fumitaka Mizoguchi, Kimito Kawahata, Dengli Wang, Masahiro Nishibori, Jessica Day, Cynthia Louis, Ian P. Wicks, Hitoshi Kohsaka, Shinsuke Yasuda
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Polymyositis (PM) is a chronic inflammatory myopathy characterized by progressive muscle weakness. Here the authors showed that muscle fibers in PM undergo necroptosis and aggravate inflammation via releasing pro-inflammatory molecules such as HMGB1.
Externí odkaz:
https://doaj.org/article/5e5ae3df2a554b49bed6089fd7ec2204
Autor:
Kiyoshi Kubota, Masaki Yoshizawa, Satoru Takahashi, Yoshiaki Fujimura, Hiroko Nomura, Hitoshi Kohsaka
Publikováno v:
BMC Musculoskeletal Disorders, Vol 22, Iss 1, Pp 1-11 (2021)
Abstract Background An administrative database covering a whole population such as the national database in Japan may be used to estimate the nationwide prevalence of diseases including rheumatoid arthritis (RA) when a well-validated definition of th
Externí odkaz:
https://doaj.org/article/0b063a3865be4959b71029f1c29faaa5
Autor:
Takashi Okumura, Yumi Horie, Chen-Yi Lai, Huan-Ting Lin, Hirofumi Shoda, Bunki Natsumoto, Keishi Fujio, Eri Kumaki, Tsubasa Okano, Shintaro Ono, Kay Tanita, Tomohiro Morio, Hirokazu Kanegane, Hisanori Hasegawa, Fumitaka Mizoguchi, Kimito Kawahata, Hitoshi Kohsaka, Hiroshi Moritake, Hiroyuki Nunoi, Hironori Waki, Shin-ichi Tamaru, Takayoshi Sasako, Toshimasa Yamauchi, Takashi Kadowaki, Hiroyuki Tanaka, Sachiko Kitanaka, Ken Nishimura, Manami Ohtaka, Mahito Nakanishi, Makoto Otsu
Publikováno v:
Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-16 (2019)
Abstract Background Disease modeling with patient-derived induced pluripotent stem cells (iPSCs) is a powerful tool for elucidating the mechanisms underlying disease pathogenesis and developing safe and effective treatments. Patient peripheral blood
Externí odkaz:
https://doaj.org/article/e9a9e96b9aae4d00878ec8608b4ef191
Autor:
Yoshiya Tanaka, Hideto Kameda, Kazuyoshi Saito, Yuko Kaneko, Eiichi Tanaka, Shinsuke Yasuda, Naoto Tamura, Keishi Fujio, Takao Fujii, Toshihisa Kojima, Tatsuhiko Anzai, Chikuma Hamada, Yoshihisa Fujino, Shinya Matsuda, Hitoshi Kohsaka
Publikováno v:
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-15 (2018)
Abstract Background Following the onset of rheumatoid arthritis (RA), patients experience a functional decline caused by various joint symptoms which affects their activities of daily living and can lead to reduced work productivity. We evaluated the
Externí odkaz:
https://doaj.org/article/c7e6bf16a6d54f34b04eb89b0e32d8dd
Autor:
Masaaki Murakami, Masaya Harada, Daisuke Kamimura, Hideki Ogura, Yuko Okuyama, Noriko Kumai, Azusa Okuyama, Rajeev Singh, Jing-Jing Jiang, Toru Atsumi, Sayaka Shiraya, Yuji Nakatsuji, Makoto Kinoshita, Hitoshi Kohsaka, Makoto Nishida, Saburo Sakoda, Nobuyuki Miyasaka, Keiko Yamaguchi-Takihara, Toshio Hirano
Publikováno v:
Cell Reports, Vol 3, Iss 3, Pp 946-959 (2013)
The IL-6-triggered positive feedback loop for NFκB signaling (or the IL-6 amplifier/Inflammation amplifier) was originally discovered as a synergistic-activation signal that follows IL-17/IL-6 stimulation in nonimmune cells. Subsequent results from
Externí odkaz:
https://doaj.org/article/3e80c577c9004439a2b643e55c7d7494
Autor:
Tianyi Liu, Hitoshi Kohsaka, Motoharu Suzuki, Rie Takagi, Kumiko Hashimoto, Yasushi Uemura, Hideki Ohyama, Sho Matsushita
Publikováno v:
Allergology International, Vol 54, Iss 1, Pp 117-122 (2005)
Background: Based on the fact that site-specific amino acid replacement on peptide antigens stimulated T cell clones to produce increased amount of IFN-γ, we investigated this structure-function relationship, using various peptide analogues. Methods
Externí odkaz:
https://doaj.org/article/f8be1fc561a34de18e7ba9255db2aa35
Autor:
Ran Nakashima, Yoshitaka Imura, Yuji Hosono, Minae Seto, Akihiro Murakami, Kizuku Watanabe, Tomohiro Handa, Michiaki Mishima, Michito Hirakata, Tsutomu Takeuchi, Keishi Fujio, Kazuhiko Yamamoto, Hitoshi Kohsaka, Yoshinari Takasaki, Noriyuki Enomoto, Takafumi Suda, Kingo Chida, Shu Hisata, Toshihiro Nukiwa, Tsuneyo Mimori
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85062 (2014)
OBJECTIVE: Autoantibodies to aminoacyl-tRNA synthetases (ARSs) are useful in the diagnosis of idiopathic inflammatory myopathy (IIM) with interstitial pneumonia (IP). We developed an enzyme-linked immunosorbent assay (ELISA) system using a mixture of
Externí odkaz:
https://doaj.org/article/1f22de8223184028b0d23a38ed30f4bd
Publikováno v:
Cell Transplantation, Vol 21 (2012)
The in vivo repopulation of hepatocytes depends on donor cell growth potential and recipient conditioning. We herein demonstrate the successful cell transplantation of a human hepatocyte cell line, THLE-5b, into the SCID mouse liver by means of a rat
Externí odkaz:
https://doaj.org/article/b5e1345accd044f8b5dddd83fddf1c59