Výsledky vyhledávání - "Hitoshi Kandori"

Akademický článek

Lobular distribution of enhanced expression levels of heat shock proteins using in-situ hybridization in the mouse liver treated with a single administration of CCl4.

Autor: Hitoshi Kandori¹ hitoshi.kandori@axcelead.com, Masami Aoki¹, Yumiko Miyamoto¹, Sayuri Nakamura¹, Ryosuke Kobayashi¹, Mitsuharu Matsumoto², Kotaro Yokoyama¹

Publikováno v: Journal of Toxicologic Pathology. 2024, Vol. 37 Issue 1, p29-37. 9p.

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Scientific and Regulatory Policy Committee Best Practices: Documentation of Sexual Maturity by Microscopic Evaluation in Nonclinical Safety Studies

Autor: Michael S. Thibodeau, Manoj Bhaskaran, Aleksandra Zalewska, Balasubramanian Manickam, Justin D. Vidal, Jonathan Werner, Wendy G. Halpern, Karyn Colman, Sean McKeag, Benjamin Sefing, Darren Fegley, Karen S. Regan, Binod Jacob, Eveline de Rijk, Vimala Vemireddi, George A. Parker, Hitoshi Kandori

Publikováno v: Toxicologic Pathology. 49:977-989

The sexual maturity status of animals in nonclinical safety studies can have a significant impact on the microscopic assessment of the reproductive system, the interpretation of potential test article–related findings, and ultimately the assessment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b875dc51afa16eb8629752f0d10e9768
https://doi.org/10.1177/0192623321990631

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No obvious toxicological influences of 50 μL microsampling from rats administered phenacetin as a drug with hematological toxicity

Autor: Hirohiko Ohtsuka, Kazuaki Takahashi, Harumi Kitaura, Hitoshi Kandori, Kenta Danbayashi, Tomoaki Higuchi, Fumihiro Jinno, Shin-ichiro Nitta, Kanae Mori, Atsushi Iwai, Keiko Nakai, Kosuke Saito, Yoshiro Saito

Publikováno v: The Journal of toxicological sciences. 47(5)

According to ICH S3A QA focusing on microsampling, its application should be avoided in main study animals for test drugs that could exacerbate hematological parameters with frequent blood sampling. However, no study has reported the effects of micro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::103c7d40e00881803fc3c1f1b4908f15
https://pubmed.ncbi.nlm.nih.gov/35527007

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Histopathological significance of microRNA-210 expression in acute peripheral ischemia in a murine femoral artery ligation model

Autor: Hitoshi Kandori, Satoshi Nishimura, Yuichi Takai, Takeshi Watanabe

Publikováno v: Journal of Toxicologic Pathology

Under hypoxic conditions, microRNA-210 is upregulated and plays multiple physiological roles including in cell growth arrest, stem cell survival, repression of mitochondrial respiration, angiogenesis, and arrest of DNA repair. In this study, we inves

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::001e1460bd6749d6514d2cd2368a33cf
https://doi.org/10.1293/tox.2020-0023

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Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs) Part III: Discovery of 4-(5-oxopyrrolidine-1-yl)benzonitrile derivative 2f as a clinical candidate

Autor: Koji Ono, Takahito Hara, Moriteru Asano, Noriyuki Habuka, Katsuji Aikawa, Hitoshi Kandori, Jason Yano, Keith Wilson, Hisashi Fujita, Takashi Santou, Masaharu Nakayama, Megumi Morimoto, Atsushi Hasuoka, Masuo Yamaoka

Publikováno v: Bioorganic & Medicinal Chemistry. 25:3330-3349

We previously reported that 4-(pyrrolidin-1-yl)benzonitrile derivative 1b was a selective androgen receptor modulator (SARM) that exhibited anabolic effects on organs such as muscles and the central nervous system (CNS), but neutral effects on the pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de1793766acf2d25ed222cdc67c948e0
https://doi.org/10.1016/j.bmc.2017.04.018

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Expression of Steroidogenic Factor 1 and Pituitary Specific Transcription Factor 1 in Rat Pituitary Adenomas

Autor: Hironobu Yasuno, Hitoshi Kandori, Takeshi Watanabe, Ryo Fukuda, Hideki Yamasaki, Yumiko Miyamoto

Publikováno v: Journal of Toxicologic Pathology

The protein expressions of steroidogenic factor l (SF-l) and pituitary-specific transcription factor 1 (Pit-1) were investigated immunohistochemically for 53 spontaneous pituitary adenomas of the pars distalis from male Crl:CD(SD) rats. Luteinizing h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::063612a10741f798d0b90e74379d27b4
https://doi.org/10.1293/tox.26.209

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Proliferative and Nonproliferative Lesions of the Rat and Mouse Male Reproductive System

Autor: Katharine M. Whitney, Axel Bube, Karen S. Regan, Régis Masson, Petrina Rogerson, Dianne M. Creasy, Hitoshi Kandori, Eveline P. C. T. de Rijk, Sabine Rehm, Thomas Nolte, Rachel Y. Reams, Maki Kuwahara

Publikováno v: Toxicologic Pathology. 40:40S-121S

The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP), and North Am

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1464838e4232b3d2b1e0c73386341c1
https://doi.org/10.1177/0192623312454337

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Suppressive effects of acid-forming diet against the tumorigenic potential of pioglitazone hydrochloride in the urinary bladder of male rats

Autor: Yasuyuki Awasaki, Masaki Yamamoto, Hirofumi Nagai, Keiichiro Sato, Zen-yo Tanakamaru, Hitoshi Kandori, David Baron

Publikováno v: Toxicology and Applied Pharmacology. 251:234-244

Pioglitazone hydrochloride (PIO), a peroxisome proliferator-activated receptor gamma (PPARγ) agonist, was administered orally for 85 weeks at 16 mg/kg/day to male rats fed either a diet containing 1.5% ammonium chloride (acid-forming diet) or a cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce39e0976238638ec7a6a8d7c4e744b2
https://doi.org/10.1016/j.taap.2011.01.006

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High mobility group box associated with cell proliferation appears to play an important role in hepatocellular carcinogenesis in rats and humans

Autor: Makoto Asamoto, Shugo Suzuki, Fumiyo Saito, Tomoyuki Shirai, Kazuo Masuko, Hitoshi Kandori, Satoru Takahashi, Kazunari Tsujimura, Kentaro Takeshita

Publikováno v: Toxicology. 255:160-170

To identify genes important in hepatocellular carcinogenesis, especially processes involved in malignant transformation, we focused on differences in gene expression between adenomas and carcinomas by DNA microarray. Eighty-one genes for which expres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7787dc21c2ca9c99fce2771c8d6759af
https://doi.org/10.1016/j.tox.2008.10.023

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Influence of atrazine administration and reduction of calorie intake on prostate carcinogenesis in probasin/SV40 T antigen transgenic rats

Autor: Tomoyuki Shirai, Shugo Suzuki, Kumiko Ogawa, Makoto Asamoto, Tang Mingxi, Toshiya Murasaki, Hitoshi Kandori

Publikováno v: Cancer Science. 96:221-226

Atrazine, which has been used worldwide as a pesticide, is now known to exert endocrine disrupting (antiandrogenic) effects in mammals. In this study, modifying effects of dietary feeding of 500 and 1000 p.p.m. atrazine on the development of androgen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d010ad2674351bd9facd5bcfa005ef5
https://doi.org/10.1111/j.1349-7006.2005.00041.x

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