Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Hitoshi ISHIZUKA"'
Autor:
Masaya Tachibana, Shunji Matsuki, Yutaro Maekawa, Kana Kuroda, Takako Shimizu, Junko Tsutsumi, Hitoshi Ishizuka
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 11, Pp 2153-2162 (2023)
Abstract Valemetostat tosylate (valemetostat) is an oral, potent, dual inhibitor of enhancer of zeste homolog (EZH) 2 and EZH1 under investigation for the treatment of cancer, including non‐Hodgkin's lymphomas and solid tumors. Itraconazole and flu
Externí odkaz:
https://doaj.org/article/25cca946004140688edddbbed881b3b2
Autor:
Ying Hong, Tomoko Ishizuka, Akiko Watanabe, Masaya Tachibana, Mark Lee, Hitoshi Ishizuka, Frank LaCreta, Malaz Abutarif
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 6, Pp 2220-2230 (2021)
Abstract Milademetan is a small‐molecule inhibitor of murine double minute 2 (MDM2) that is in clinical development for advanced solid tumors and hematological cancers, including liposarcoma and acute myeloid leukemia. Milademetan is a CYP3A and P
Externí odkaz:
https://doaj.org/article/e9cdb914f78a466084a85f5aa18226a3
Pharmacokinetic interactions of esaxerenone with amlodipine and digoxin in healthy Japanese subjects
Autor:
Yoshiaki Kirigaya, Masanari Shiramoto, Tomoko Ishizuka, Hinako Uchimaru, Shin Irie, Manabu Kato, Takako Shimizu, Takafumi Nakatsu, Yasuhiro Nishikawa, Hitoshi Ishizuka
Publikováno v:
BMC Pharmacology and Toxicology, Vol 21, Iss 1, Pp 1-10 (2020)
Abstract Background To investigate the effects of coadministration of esaxerenone with amlodipine on the pharmacokinetics (PK) of each drug, and of esaxerenone on the PK of digoxin. Methods In three open-label, single-sequence, crossover studies, hea
Externí odkaz:
https://doaj.org/article/c39e71805f0e44b8b24ece08b36c520b
Autor:
Yi Li, Kaoru Toyama, Takafumi Nakatsu, Hitoshi Ishizuka, Hailan Wu, Guoying Cao, Jicheng Yu, Yu Wang, Xiaofen Liu, Beining Guo, Jufang Wu, Peimin Yu, Zhen Hong, Jing Zhang, Xiaojie Wu
Publikováno v:
Advances in Therapy. 40:1628-1643
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c20e5d4670ade350c3aa55b6c12f590d
https://doi.org/10.1007/s12325-022-02424-7
https://doi.org/10.1007/s12325-022-02424-7
Autor:
Akifumi, Kurata, Takashi, Eto, Junko, Tsutsumi, Yoshiyuki, Igawa, Yasuhiro, Nishikawa, Hitoshi, Ishizuka
Publikováno v:
Clinical Pharmacology in Drug Development. 11:957-965
We assessed the bioequivalence of a single dose of 5-mg of esaxerenone administered as an orally disintegrating tablet (ODT) with the conventional oral tablet in healthy Japanese men. This single-center, open-label, randomized, two-drug, two-stage cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7adff67cce0c2f23dbe56d097f4d88fe
https://doi.org/10.1002/cpdd.1087
https://doi.org/10.1002/cpdd.1087
Autor:
Toshihiko Nakatani, Kazuhito Shiosakai, Tatsuya Hashimoto, Masao Shionoya, Takaaki Akasaka, Kaoru Toyama, Hitoshi Ishizuka, Yoji Saito
Publikováno v:
Journal of palliative medicine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97e5bc50166d55c3f72530825b6bc2cf
https://pubmed.ncbi.nlm.nih.gov/36579915
https://pubmed.ncbi.nlm.nih.gov/36579915
Pharmacokinetic interactions of esaxerenone with amlodipine and digoxin in healthy Japanese subjects
Autor:
Takafumi Nakatsu, Masanari Shiramoto, Yoshiaki Kirigaya, Takako Shimizu, Shin Irie, Tomoko Ishizuka, Yasuhiro Nishikawa, Hinako Uchimaru, Hitoshi Ishizuka, Manabu Kato
Publikováno v:
BMC Pharmacology and Toxicology, Vol 21, Iss 1, Pp 1-10 (2020)
BMC Pharmacology & Toxicology
BMC Pharmacology & Toxicology
Background To investigate the effects of coadministration of esaxerenone with amlodipine on the pharmacokinetics (PK) of each drug, and of esaxerenone on the PK of digoxin. Methods In three open-label, single-sequence, crossover studies, healthy Japa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::423419733856e9768cc70b02968cfc92
http://link.springer.com/article/10.1186/s40360-020-00423-4
http://link.springer.com/article/10.1186/s40360-020-00423-4
Autor:
Takafumi Nakatsu, Hitoshi Ishizuka, Takako Shimizu, Tomoko Ishizuka, Shin Irie, Manabu Kato, Hinako Uchimaru, Yasuhiro Nishikawa, Masanari Shiramoto, Yoshiaki Kirigaya
Publikováno v:
British Journal of Clinical Pharmacology
Aims To investigate the effects of the strong cytochrome P450 (CYP) 3A inhibitor itraconazole and the strong CYP3A inducer rifampicin on the pharmacokinetics of single-dose esaxerenone, a nonsteroidal mineralocorticoid receptor blocker, in healthy Ja
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eef6b0b92c709e3c5ef5f501d83988ae
http://europepmc.org/articles/PMC7495282
http://europepmc.org/articles/PMC7495282
Autor:
Megumi Inoue, Tomoko Ishizuka, Akifumi Kurata, Hitoshi Ishizuka, Manabu Kato, Takafumi Yoshida, Takafumi Nakatsu, Takako Shimizu, Yasuhiro Nishikawa
Publikováno v:
Advances in Therapy
Introduction The mineralocorticoid receptor (MR) blocker esaxerenone is a new treatment for hypertension in Japan and under development for treatment of diabetic nephropathy. Hepatic impairment is known to impact the pharmacokinetics (PKs) of other M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caceb0f452b44480dc3084747e766f62
https://doi.org/10.1007/s12325-019-01121-2
https://doi.org/10.1007/s12325-019-01121-2
Publikováno v:
Advances in Therapy
Introduction Memantine hydrochloride, an N-methyl-D-aspartate receptor antagonist, is used to treat Alzheimer’s disease (AD). A new dry syrup formulation containing memantine hydrochloride has been developed to improve medication adherence in AD pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::652587431f4933c1a3c1069105a8723a
https://doi.org/10.1007/s12325-019-01044-y
https://doi.org/10.1007/s12325-019-01044-y