Výsledky vyhledávání - "Hitoshi Hori"

Akademický článek

Latent pH-responsive ratiometric fluorescent cluster based on self-assembled photoactivated SNARF derivatives

Autor: Eiji Nakata, Yoshihiro Yukimachi, Yoshihiro Uto, Hitoshi Hori, Takashi Morii

Publikováno v: Science and Technology of Advanced Materials, Vol 17, Iss 1, Pp 431-436 (2016)

We have developed a self-assembled fluorescent cluster comprising a seminaphthorhodafluor (SNARF) derivative protected by a photoremovable o-nitrobenzyl group. Prior to UV irradiation, a colorless and nonfluorescent cluster was spontaneously assemble

Externí odkaz: https://doaj.org/article/7e358319add44c4a88400b53191882e7

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Akademický článek

Crystal structure of (2-{[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl](5-methyl-2H-pyrrol-2-ylidene)methyl}-5-methyl-1H-pyrrolido-κ2N,N′)difluoridoboron

Autor: Yukio Morimoto, Keizo Ogawa, Yoshihiro Uto, Hideko Nagasawa, Hitoshi Hori

Publikováno v: Acta Crystallographica Section E: Crystallographic Communications, Vol 71, Iss 9, Pp o694-o695 (2015)

The title compound, C25H31BF2N2O, is a potential boron tracedrug in boron neutron capture therapy (BNCT), in which the B atom adopts a distorted BN2F2 tetrahedral geometry: it is soluble in dimethyl sulfoxide, dimethylformamide and methanol. The pyrr

Externí odkaz: https://doaj.org/article/5551cda0d12240ad909dce972cb5682c

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Akademický článek

Determination of Genotype and Phenotypes in Pediatric Patients With Biventricular Noncompaction

Autor: Keiichi Hirono, Yukiko Hata, Teruhiko Imamura, Kaori Tsuboi, Shinya Takarada, Mako Okabe, Hideyuki Nakaoka, Keijiro Ibuki, Sayaka Ozawa, Shojiro Ichimata, Naoki Nishida, Hidenori Iwasaki, Susumu Urata, Seigo Okada, Tomoya Hiratsuji, Heima Sakaguchi, Kiyohiro Takigiku, Makoto Nakazawa, Eiki Nishihara, Masako Harada, Osamu Matsuo, Kenji Yasuda, Yoko Yoshida, Hidemasa Namiki, Kazushi Yasuda, Toshinobu Ifuku, Kotaro Urayama, Hideharu Oka, Kayo Ogino, Akio Kato, Nobuhiko Kan, Shunji Seki, Mitsuru Seki, Yutaka Odanaka, Satoru Iwashima, Shuichiro Yoshida, Toyohisa Miyata, Tomoyuki Miyamoto, Ken Watanabe, Naoki Kuwabara, Ryo Inuzuka, Yoshihiro Takahashi, Hisanori Sakazaki, Jun Muneuchi, Shigetoyo Kogaki, Fujito Numano, Sachiko Kido, Masaki Nii, Shinsuke Hoshino, Hidekazu Ishida, Jun Maeda, Yasunobu Hayabuchi, Yoshikazu Otsubo, Kazuyuki Ikeda, Shinya Tsukano, Makoto Watanabe, Nobuo Momoi, Takanari Fujii, Tao Fujioka, Mitsuhiro Fujino, Hiroki Uchiyama, Shigehito Baba, Hitoshi Horigome, Takashi Honda, Kazutaka Suzuki, Fukiko Ichida

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 21 (2024)

Background Left ventricular noncompaction (LVNC) is a hereditary type of cardiomyopathy characterized by prominent trabeculations. Detailed characteristics of biventricular noncompaction (BiVNC) remain unknown. This study aimed to elucidate the clini

Externí odkaz: https://doaj.org/article/0f80e1600f4e43fb837026a73925f862

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Correlation Between Radiosensitizing Activity and the Stereo-structure of the TX-2036 Series of Molecules

Autor: Atsushi Tabata, Yoshihiro Uto, Kazuto Ohkura, Hitoshi Hori

Publikováno v: Anticancer Research. 39:4479-4483

Background/aim The stereo-configuration (R-, S-configuration) of chiral-2-nitroimidazole derivatives alters their radiosensitizing activity. This study aimed at examining the molecular features of these enantiomers by molecular simulation techniques.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::112ebe84c2d39b6eb46305d327a7e066
https://doi.org/10.21873/anticanres.13622

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Effect of Isomerization of TX-2036 Derivatives on the Interaction With Tyrosine Kinase Domain of EGF Receptor

Autor: Kazuto Ohkura, Hitoshi Hori, Yoshihiro Uto, Atsushi Tabata

Publikováno v: Anticancer research. 40(8)

Background From the design and synthesis of enantiomers, we can expect to obtain two compounds with different pharmacokinetics and pharmacological activities at the same time, which is thought to lead to the development of efficient anticancer agents

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10352c525ea50ba4a06d24356adcb210
https://pubmed.ncbi.nlm.nih.gov/32727791

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Akademický článek

Corrigendum: Use of the index of pulmonary vascular disease for predicting longterm outcome of pulmonary arterial hypertension associated with congenital heart disease

Autor: Ayako Chida-Nagai, Naoki Masaki, Kay Maeda, Konosuke Sasaki, Hiroki Sato, Jun Muneuchi, Yoshie Ochiai, Hiroomi Murayama, Masahiro Tahara, Atsuko Shiono, Atsushi Shinozuka, Fumihiko Kono, Daisuke Machida, Shinichi Toyooka, Seiichiro Sugimoto, Kazufumi Nakamura, Satoshi Akagi, Maiko Kondo, Shingo Kasahara, Yasuhiro Kotani, Junichi Koizumi, Katsuhiko Oda, Masako Harada, Daisuke Nakajima, Akira Murata, Hazumu Nagata, Koichi Yatsunami, Tomio Kobayashi, Yoshikiyo Matsunaga, Takahiro Inoue, Hiroyuki Yamagishi, Naomi Nakagawa, Katsuki Ohtani, Masaki Yamamoto, Yushi Ito, Tatsunori Hokosaki, Yuta Kuwahara, Satoshi Masutani, Koji Nomura, Tsutomu Wada, Hirofumi Sawada, Masayuki Abiko, Tatsunori Takahashi, Yuichi Ishikawa, Seigo Okada, Atsushi Naitoh, Takako Toda, Tatsuya Ando, Akihiro Masuzawa, Shinsuke Hoshino, Masaaki Kawada, Yuichi Nomura, Kentaro Ueno, Naoki Ohashi, Tsuyoshi Tachibana, Yuchen Cao, Hideaki Ueda, Sadamitsu Yanagi, Masaaki Koide, Norie Mitsushita, Kouji Higashi, Yoshihiro Minosaki, Tomohiro Hayashi, Takashi Okamoto, Kenji Kuraishi, Eiji Ehara, Hidekazu Ishida, Hitoshi Horigome, Takashi Murakami, Kohta Takei, Taku Ishii, Gen Harada, Yasutaka Hirata, Jun Maeda, Shunsuke Tatebe, Chiharu Ota, Yasunobu Hayabuchi, Hisanori Sakazaki, Takashi Sasaki, Keiichi Hirono, Sayo Suzuki, Masahiro Yasuda, Atsuhito Takeda, Madoka Sawada, Kagami Miyaji, Atsushi Kitagawa, Yosuke Nakai, Nobuyuki Kakimoto, Kouta Agematsu, Atsushi Manabe, Yoshikatsu Saiki

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 11 (2024)

Externí odkaz: https://doaj.org/article/68a7688d57a144bc8a79c02949934092

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Structural Insight Into Protein Binding of Boron Tracedrug UTX-97 Revealed by the Co-Crystal Structure With Lysozyme at 1.26 Å Resolution

Autor: Yukio Morimoto, Hitoshi Hori, Hideko Nagasawa, Toshiyuki Chatake, Yoshihiro Uto

Publikováno v: Journal of Pharmaceutical Sciences. 105:2298-2301

Boron neutron capture therapy (BNCT) is one of the numbers of radiotherapies for treatment of certain cancers. The ability of low-dose irradiation with neutrons or radioactive beams to provide an acceptable quality of life is an objective which has n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::766fa732bc4f611b3f25c951543f9cdc
https://doi.org/10.1016/j.xphs.2016.06.005

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Structure-associated Functional Control of TX-1877 Series by Glyco-conjugation

Autor: Yoshihiro Uto, Yuki Kawaguchi, Kazuto Ohkura, Hitoshi Hori, Yohei Tatematsu, Atsushi Tabata

Publikováno v: Anticancer research. 38(7)

Background/aim Sugar molecules are often used as a tool to structurally modify chemical compounds. The features of synthesized sugar-conjugated TX-1877 derivatives were herein examined. Materials and methods The molecular stabilities (reactivity) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9b6f45340cef7d3f1f072370e0e2348
https://pubmed.ncbi.nlm.nih.gov/29970557

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Akademický článek

Use of the index of pulmonary vascular disease for predicting long-term outcome of pulmonary arterial hypertension associated with congenital heart disease

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 10 (2023)

AimsLimited data exist on risk factors for the long-term outcome of pulmonary arterial hypertension (PAH) associated with congenital heart disease (CHD-PAH). We focused on the index of pulmonary vascular disease (IPVD), an assessment system for pulmo

Externí odkaz: https://doaj.org/article/a0503c2d2e004c1599714824bff4c9ec

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Interactive Analysis of TX-1123 with Cyclo-oxygenase: Design of COX2 Selective TX Analogs

Autor: Yuki Kawaguchi, Yoshihiro Uto, Yohei Tatematsu, Hitoshi Hori, Kazuto Ohkura

Publikováno v: Anticancer Research. 37

BACKGROUND To date, two cyclo-oxygenase (COX) isoforms, COX1 and COX2, have been identified. In the present study, the COX-inhibitory activities of TX-1123 derivatives with the 2-hydroxyarylidene-4-cyclopentene-1,3-dione structure were examined, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5893d3839395e23538f3d898e4f23c7
https://doi.org/10.21873/anticanres.11764

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