Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Hitoshi Doihara"'
Autor:
Sadao Kuromitsu, Masafumi Kudoh, Hitoshi Doihara, Takashi Furutani, Hideki Sakagami, Takatoshi Soga, Nobuaki Shindou, Kenichi Mori, Rika Saito, Yutaka Kondoh, Itsuro Shimada, Hiroshi Fushiki, Satoshi Konagai, Yoko Ueno, Masamichi Mori
Activation of anaplastic lymphoma receptor tyrosine kinase (ALK) is involved in the pathogenesis of several carcinomas, including non–small cell lung cancer (NSCLC). Echinoderm microtubule–associated protein like 4 (EML4)-ALK, which is derived fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37459d8fd025c0aa252300682e939c06
https://doi.org/10.1158/1535-7163.c.6536752.v1
https://doi.org/10.1158/1535-7163.c.6536752.v1
Autor:
Sadao Kuromitsu, Masafumi Kudoh, Hitoshi Doihara, Takashi Furutani, Hideki Sakagami, Takatoshi Soga, Nobuaki Shindou, Kenichi Mori, Rika Saito, Yutaka Kondoh, Itsuro Shimada, Hiroshi Fushiki, Satoshi Konagai, Yoko Ueno, Masamichi Mori
PDF file - 64K, Inhibition of ALK phosphorylation and signal transduction in NCI-H2228 cells by ASP3026.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8191a9c270c42509f89630903befdd52
https://doi.org/10.1158/1535-7163.22501333.v1
https://doi.org/10.1158/1535-7163.22501333.v1
Autor:
Sadao Kuromitsu, Masafumi Kudoh, Hitoshi Doihara, Takashi Furutani, Hideki Sakagami, Takatoshi Soga, Nobuaki Shindou, Kenichi Mori, Rika Saito, Yutaka Kondoh, Itsuro Shimada, Hiroshi Fushiki, Satoshi Konagai, Yoko Ueno, Masamichi Mori
PDF file - 82K, Inhibitory activity of ASP3026 and crizotinib against various TKs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21313f18e6abbb4228948c2e5e3dabe4
https://doi.org/10.1158/1535-7163.22501336
https://doi.org/10.1158/1535-7163.22501336
Autor:
Sadao Kuromitsu, Masafumi Kudoh, Hitoshi Doihara, Takashi Furutani, Hideki Sakagami, Takatoshi Soga, Nobuaki Shindou, Kenichi Mori, Rika Saito, Yutaka Kondoh, Itsuro Shimada, Hiroshi Fushiki, Satoshi Konagai, Yoko Ueno, Masamichi Mori
PDF file - 445K, Growth of H2228-luc cells directly inoculated into the pleural cavity of NOD/SCID mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bad5dc227138cbf524227b69d2b4a26
https://doi.org/10.1158/1535-7163.22501345.v1
https://doi.org/10.1158/1535-7163.22501345.v1
Autor:
Sadao Kuromitsu, Masafumi Kudoh, Hitoshi Doihara, Takashi Furutani, Hideki Sakagami, Takatoshi Soga, Nobuaki Shindou, Kenichi Mori, Rika Saito, Yutaka Kondoh, Itsuro Shimada, Hiroshi Fushiki, Satoshi Konagai, Yoko Ueno, Masamichi Mori
PDF file - 56K, Pharmacokinetic parameters of ASP3026 after 5-day repeated oral dosing of ASP3026 in NOD/SCID mice xenografted with NCI-H2228 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bcfa7353e927b74fbd7543ff62e1c46
https://doi.org/10.1158/1535-7163.22501330
https://doi.org/10.1158/1535-7163.22501330
Autor:
Sadao Kuromitsu, Masafumi Kudoh, Hitoshi Doihara, Takashi Furutani, Hideki Sakagami, Takatoshi Soga, Nobuaki Shindou, Kenichi Mori, Rika Saito, Yutaka Kondoh, Itsuro Shimada, Hiroshi Fushiki, Satoshi Konagai, Yoko Ueno, Masamichi Mori
PDF file - 68K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68ee04571291c1ce223e22fc3eb6ccd9
https://doi.org/10.1158/1535-7163.22501339.v1
https://doi.org/10.1158/1535-7163.22501339.v1
Autor:
Sadao Kuromitsu, Masafumi Kudoh, Hitoshi Doihara, Takashi Furutani, Hideki Sakagami, Takatoshi Soga, Nobuaki Shindou, Kenichi Mori, Rika Saito, Yutaka Kondoh, Itsuro Shimada, Hiroshi Fushiki, Satoshi Konagai, Yoko Ueno, Masamichi Mori
PDF file - 6669K, Antitumor activities of ASP3026 in hEML4-ALK transgenic mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ebccab6f996259b9b2d5b5a8402bcd3
https://doi.org/10.1158/1535-7163.22501348
https://doi.org/10.1158/1535-7163.22501348
Autor:
Yutaka Kondoh, Hitoshi Doihara, Takashi Furutani, Hideki Sakagami, Takatoshi Soga, Hiroshi Fushiki, Nobuaki Shindou, Kenichi Mori, Sadao Kuromitsu, Itsuro Shimada, Masamichi Mori, Masafumi Kudoh, Satoshi Konagai, Rika Saito, Yoko Ueno
Publikováno v:
Molecular Cancer Therapeutics. 13:329-340
Activation of anaplastic lymphoma receptor tyrosine kinase (ALK) is involved in the pathogenesis of several carcinomas, including non–small cell lung cancer (NSCLC). Echinoderm microtubule–associated protein like 4 (EML4)-ALK, which is derived fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9555f56307090c527f5360ebb1f43641
https://doi.org/10.1158/1535-7163.mct-13-0395
https://doi.org/10.1158/1535-7163.mct-13-0395
Autor:
Noritaka Hamada, Shuichi Sakamoto, Itsuro Shimada, Tetsuya Kimizuka, Takashi Sugane, Kyouko Saita, Atsuyuki Kohara, Masaki Aota, Shin-ichi Tsukamoto, Takahiko Tobe, Wataru Hamaguchi, Morita Takuma, Hitoshi Doihara, Kyoichi Maeno, Yoshiaki Shimada, Takeshi Suzuki, Masako Furutani, Junji Miyata
Publikováno v:
Journal of Medicinal Chemistry. 54:387-391
We describe the preparation and evaluation of a novel series of glycine transporter 1 (GlyT1) inhibitors derived from a high-throughput screening hit. The SAR studies resulted in the discovery of 3-biphenyl-4-yl-4-(2-fluorophenyl)-5-isopropyl-4H-1,2,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2789e044bb39555326be6d6cc73efdb
https://doi.org/10.1021/jm101031u
https://doi.org/10.1021/jm101031u
Autor:
Hidetaka Kaku, Ryosuke Kojima, Toshihide Yokoyama, Hiroyuki Itou, Hitoshi Doihara, Yoshihiro Keto, Katsura Nozawa
Publikováno v:
European journal of pharmacology. 723
Constipation is a major gastrointestinal motility disorder with clinical need for effective drugs. We previously reported that transient receptor potential ankyrin 1 (TRPA1) is highly expressed in enterochromaffin (EC) cells, which are 5-hydroxytrypt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::319ce0d33df67033f407dda20b410d00
https://pubmed.ncbi.nlm.nih.gov/24291101
https://pubmed.ncbi.nlm.nih.gov/24291101