Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Hitoshi Aihara"'
Autor:
Lavanya Katikala, Hitoshi Aihara, Yale J Passamaneck, Stefan Gazdoiu, Diana S José-Edwards, Jamie E Kugler, Izumi Oda-Ishii, Janice H Imai, Yutaka Nibu, Anna Di Gregorio
Publikováno v:
PLoS Biology, Vol 11, Iss 10, p e1001697 (2013)
The appearance of the notochord represented a milestone in Deuterostome evolution. The notochord is necessary for the development of the chordate body plan and for the formation of the vertebral column and numerous organs. It is known that the transc
Externí odkaz:
https://doaj.org/article/3afe01d8c72f49d2b75bc32adec0d804
Publikováno v:
PLoS Genetics, Vol 8, Iss 3, p e1002547 (2012)
The activities of developmentally critical transcription factors are regulated via interactions with cofactors. Such interactions influence transcription factor activity either directly through protein-protein interactions or indirectly by altering t
Externí odkaz:
https://doaj.org/article/f1c471e72546497eb559a4fbaffbc52a
Autor:
Toyomasa Katagiri, Masaya Ono, Hitoshi Aihara, Koichi Tsuneyama, Koichi Sairyo, Tetsuro Yoshimaru, Shunichi Toki, Yosuke Matsushita
Publikováno v:
Cancer Science
Previous studies reported the critical role of the brefeldin A–inhibited guanine nucleotide exchange protein 3–prohibitin 2 (BIG3‐PHB2) complex in modulating estrogen signaling activation in breast cancer cells, yet its pathophysiological roles
Autor:
Haruhiko Koseki, Yoshiaki Kodama, Satoshi Inoue, Takashi Ito, Hirofumi Mizusaki, Masanori Kato, Tomonori Hayashi, Edwin Cheung, Mitsuhiro Yoneda, Yukio Takeshima, Takeya Nakagawa, Hitoshi Aihara, Tsuyoshi Ikura, Masaya Oki, Ken-ichi Takayama, Yuko Imamura, Masamichi Doiguchi, Miki Higashi, Toshiyuki Nakayama, Hiroyuki Aburatani
Publikováno v:
Molecular Cell. 64:176-188
How deregulation of chromatin modifiers causes malignancies is of general interest. Here, we show that histone H2A T120 is phosphorylated in human cancer cell lines and demonstrate that this phosphorylation is catalyzed by hVRK1. Cyclin D1 was one of
Autor:
Yuko Imamura, Masamichi Doiguchi, Miki Higashi, Satoshi Fujii, Takeya Nakagawa, Daishi Inoue, Tatsuharu Sato, Akihiko Okuda, Takashi Ito, Mitsuhiro Yoneda, Hirofumi Mizusaki, Takayuki Miyanishi, Hitoshi Aihara
Publikováno v:
Scientific Reports
In mouse embryonic stem (mES) cells, ubiquitylation of histone H2A lysine 119 represses a large number of developmental genes and maintains mES cell pluripotency. It has been suggested that a number of H2A ubiquitin ligases as well as deubiquitylases
Autor:
Dereje Negeri, Mark D. Stern, Lila Cheung, Giorgio A. Roccaro, Hitoshi Aihara, Hailan Zhang, Yutaka Nibu
Publikováno v:
Mechanisms of Development. 126(1-2):68-79
C-terminal binding protein (CtBP) is an evolutionarily and functionally conserved transcriptional corepressor known to integrate diverse signals to regulate transcription. Drosophila CtBP (dCtBP) regulates tissue specification and segmentation during
Publikováno v:
The EMBO Journal. 27:898-909
The Drosophila Snail protein is a transcriptional repressor that is necessary for mesoderm formation. Here, we identify the Ebi protein as an essential Snail co-repressor. In ebi mutant embryos, Snail target genes are derepressed in the presumptive m
Publikováno v:
Developmental Biology. 305:650-658
The CBP protein is a transcriptional co-activator and histone acetyltransferase. Reduced expression of Drosophila CBP (dCBP) in the early embryo specifically impairs signaling by the TGF-β molecules Dpp and Screw (Scw). This occurs by a failure to a
Publikováno v:
Fundamentals of Chromatin ISBN: 9781461486237
Histone posttranslational modifications are key components of crucial steps in controlling eukaryotic genomes. These modifications, including reversible acetylation, phosphorylation and methylation, function as signals during various chromatin-relate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e548779414d6a257987f378550ae6ea3
https://doi.org/10.1007/978-1-4614-8624-4_8
https://doi.org/10.1007/978-1-4614-8624-4_8
Autor:
Hitoshi Aihara, Keisuke Endo, Yoshiyuki Tamura, Michiyo Yamazaki, Masatoshi Horiuchi, Syuichi Watanabe, Makoto Sakai
Publikováno v:
Koutou (THE LARYNX JAPAN). 9:49-53