Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Hitoshi, Mizuo"'
Autor:
Hitoshi Mizuo, Yuji Mano
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Lenvatinib (Lenvima) is a tyrosine kinase inhibitor on the market and has been used for the treatment of various types of cancer. It is important to understand differences in pharmacokinetics (PK) between nonclinical animals and humans, and
Externí odkaz:
https://doaj.org/article/567dc092d1eb4bfd8e29acf179e8c5c7
Autor:
Junichi, Koyama, Atsushi, Uesugi, Ryogo, Himori, Hideo, Takagi, Ryutaro, Morizono, Masahide, Uchizawa, Hitoshi, Mizuo
Publikováno v:
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology. 119(4)
Sleeve gastrectomy was covered by Japan's national health insurance as bariatric surgery for morbid obesity in 2014. There are a few cases of gastric bypass surgery, which is a different procedure. Given that the current incidence of gastric cancer i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3a0d7834fa3317f5f8a0703e2427b794
https://pubmed.ncbi.nlm.nih.gov/35400688
https://pubmed.ncbi.nlm.nih.gov/35400688
Autor:
Hiroyuki Matsuoka, Emiko Fukui, Hiroaki Okamoto, Manri Kawakami, Akira Nishizono, Kazumoto Murata, Emiko Isogai, Masaharu Takahashi, Hitoshi Mizuo, Shigeo Nagashima, Seigo Yamamoto
Publikováno v:
Virus research. 308
Hepatitis E virus (HEV) is a zoonotic agent mainly transmitted through the consumption of uncooked or undercooked meat products derived from infected animals. In Japan, domestic pigs and wild boars are the major animal reservoirs, and whether or not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::618950ddf6da311a3f8bd94069391e8b
https://pubmed.ncbi.nlm.nih.gov/34822952
https://pubmed.ncbi.nlm.nih.gov/34822952
Autor:
Tsutomu Nishizawa, Masaharu Takahashi, Hiroyuki Matsuoka, Akira Nishizono, Seigo Yamamoto, Emiko Fukui, Hitoshi Mizuo, Manri Kawakami, Kazumoto Murata, Hiroaki Okamoto
Publikováno v:
Virus Research. 314:198749
A preliminary metagenomic analysis of the virome of wild sika deer (Cervus nippon) blood in Japan resulted in the identification of a novel parvovirus. The virus was closest, but only 44.7-60.7% identical to 17 reported strains belonging to the genus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58affddfdf1094f1f0e4a66478767658
https://doi.org/10.1016/j.virusres.2022.198749
https://doi.org/10.1016/j.virusres.2022.198749
To reveal putative bioactivation pathways of diclofenac, in vitro human liver materials such as microsomal fractions and hepatocytes were used to confirm metabolic activation of diclofenac by 35S-cysteine trapping assay and covalent binding assay. Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1c2a6d51268068460309a76cb863556
Autor:
Junichi Koyama, Hiroshi Okano, Tatsunori Nakano, Kojiro Takase, Yoichi Nishigaki, Kazuto Ikezawa, Eiichi Tomita, Kazushi Sugimoto, Tatsuya Aikawa, Masahiro Arai, Kazuaki Takahashi, Hitoshi Mizuo, Yumi Oya, Katsuya Shiraki, Shigeo Nagashima, Masaharu Takahashi, Hiroaki Okamoto, Yusuke Suzuki
Publikováno v:
Virology. 513:146-152
Hepatitis E virus subtype 3f (HEV-3f) strains are usually isolated in Europe and Thailand. Recently, HEV-3f strains were detected from six acute hepatitis E patients in Japan, none of whom had a history of travel to endemic areas. We inferred the ori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54cb64ecc4e5397bdbf777fc186cf3de
https://doi.org/10.1016/j.virol.2017.08.008
https://doi.org/10.1016/j.virol.2017.08.008
Autor:
Hitoshi Mizuo, Yuji Mano
Publikováno v:
Biopharmaceuticsdrug dispositionREFERENCES. 40(8)
Plasma protein binding (PPB) can be different depending on the status of hepatic or renal functions. In this study, the PPB of lenvatinib was determined using equilibrium dialysis in plasma from healthy volunteers and from subjects with mild, moderat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f7274a51b4226759e1840e26616fc71
https://pubmed.ncbi.nlm.nih.gov/31426119
https://pubmed.ncbi.nlm.nih.gov/31426119
Autor:
Hitoshi Mizuo, Jos H. Beijnen, Robert S. Jansen, A. C. Dubbelman, David Critchley, Shinki Kawaguchi, Hilde Rosing, Jan H.M. Schellens, C.M. Nijenhuis, Robert Shumaker
Publikováno v:
Investigational New Drugs, 34(3), 300. Kluwer Academic Publishers
Lenvatinib is an oral, multiple receptor tyrosine kinase inhibitor. Preclinical drug metabolism studies showed unique metabolic pathways for lenvatinib in monkeys and rats. A human mass balance study demonstrated that lenvatinib related material is m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dd39856658a15cba71a6c483e7e6307
https://doi.org/10.1007/s10637-016-0342-y
https://doi.org/10.1007/s10637-016-0342-y
Autor:
Tatsuya Aikawa, Kozo Ashida, Yuuji Kodera, Kunihiko Oguro, Manri Kawakami, Fumihiro Hayakawa, Hiroyuki Matsuoka, Hitoshi Mizuo, Tsutomu Nishizawa, Kazumoto Murata, Hideaki Ozaki, Tomoko Tamaru, Masaharu Takahashi, Shinichi Miyazaki, Hideo Hirose, Hiroaki Okamoto, Shigeo Nagashima, Yukihiro Sato, Masahiko Irokawa
Publikováno v:
Virus Research. 287:198106
To further investigate the prevalence of hepatitis E virus (HEV) infection and characterize HEV genomes among Japanese wild boars (Sus scrofa leucomystax), 1880 boars captured in 17 prefectures in Japan from 2013 to 2019 were studied. Overall, anti-H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80009f047d1c71960c042b5c6791bd94
https://doi.org/10.1016/j.virusres.2020.198106
https://doi.org/10.1016/j.virusres.2020.198106
Publikováno v:
European journal of drug metabolism and pharmacokinetics. 42(6)
Lenvatinib is a multikinase inhibitor that targets vascular endothelial growth factor (VEGF) receptors 1–3, fibroblast growth factor receptors 1–4, platelet-derived growth factor receptor-alpha, and RET and KIT proto-oncogenes. Lenvatinib is appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::258186bc604049b6ebd1142e382cce1f
https://pubmed.ncbi.nlm.nih.gov/28236116
https://pubmed.ncbi.nlm.nih.gov/28236116