Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Hitoshi, Hamashima"'
Autor:
Kenichi Washizuka, Yasuhiro Matsumura, Yasuyo Tomishima, Keiko Nakano, Naoko Unami, Fujiko Takamura, Takanobu Araki, Shigeo Matsui, Minoru Sakurai, Masashi Imanishi, Takao Yamamoto, Kaori Hamada, Kouji Hattori, Hitoshi Hamashima, Nobuhiro Yamamoto, Emiko Imamura, Hirofumi Ishikawa, Koji Ueshima, Yutaka Nakajima, Susumu Toda, Shinji Itou
Publikováno v:
Journal of Medicinal Chemistry. 52:3063-3072
As an extension of research conducted on beta(3)-adrenergic receptor agonists as potential drugs for treating overactive bladder (OAB), novel series containing an acylsulfonamide moiety instead of the carboxylic acid moiety were evaluated. These comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db696b5f389955fb00201a425aef2632
https://doi.org/10.1021/jm9000709
https://doi.org/10.1021/jm9000709
Autor:
Masashi, Imanishi, Yasuyo, Tomishima, Shinji, Itou, Hitoshi, Hamashima, Yutaka, Nakajima, Kenichi, Washizuka, Minoru, Sakurai, Shigeo, Matsui, Emiko, Imamura, Koji, Ueshima, Takao, Yamamoto, Nobuhiro, Yamamoto, Hirofumi, Ishikawa, Keiko, Nakano, Naoko, Unami, Kaori, Hamada, Yasuhiro, Matsumura, Fujiko, Takamura, Kouji, Hattori
Publikováno v:
Journal of Medicinal Chemistry. 51:1925-1944
A novel class of biphenyl analogues containing a benzoic acid moiety based on lead compound 8i have been identified as potent and selective human beta 3 adrenergic receptor (beta 3-AR) agonists with good oral bioavailability and long plasma half-life
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3df2218288fe87564bacbf9f841e0ed
https://doi.org/10.1021/jm701324c
https://doi.org/10.1021/jm701324c
Autor:
Yasuyo Tomishima, Kenichi Washizuka, Masayuki Kato, Hitoshi Hamashima, Yutaka Nakajima, Toshiko Miura, Hiroshi Kayakiri, Emiko Imamura, Hiroaki Ohtake
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:251-254
The discovery of a novel, potent and selective β3-adrenergic receptor (AR) agonist is described. SAR studies demonstrated the structural requirements for activity and selectivity. Compound 1c, which showed good β3-AR activity and selectivity, was i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46cba7b3143ff5d369186e60ac75f43d
https://doi.org/10.1016/j.bmcl.2004.11.001
https://doi.org/10.1016/j.bmcl.2004.11.001
Publikováno v:
Bulletin of the Chemical Society of Japan. 73:2559-2562
Asymmetric Michael addition of diethyl (1-cyanoethyl)phosphonate with vinyl ketones or acrylaldehyde in the presence of 0.01 molar amount of a rhodium catalyst prepared in situ from Rh(acac)(CO)2 and a trans-chelating chiral diphosphine ligand (R,R)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20516fb3931c4dad499b1f8fe8cb7714
https://doi.org/10.1246/bcsj.73.2559
https://doi.org/10.1246/bcsj.73.2559
Publikováno v:
Organometallics. 14:4549-4558
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59d0a8a44ae5f14a5d78e213e6e13d13
https://doi.org/10.1021/om00010a020
https://doi.org/10.1021/om00010a020
Publikováno v:
Tetrahedron Letters. 36:6479-6482
Asymmetric Michael reaction of N -methoxy- N -methyl-2-cyanopropionamide with vinyl ketones or acrolein in the presence of 0.1–1 mol% of a rhodium catalyst prepared in situ from Rh(acac)(CO) 2 and a trans-chelating chiral diphosphine ligand ( S , S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd11a34e5b27cc463ab529150b79901c
https://doi.org/10.1016/0040-4039(95)01295-s
https://doi.org/10.1016/0040-4039(95)01295-s
Publikováno v:
Tetrahedron. 50:4439-4454
Asymmetric Michael reaction of 2-cyanopropionates with vinyl ketones or acrolein in the presence of 0.1–1 mol% of a rhodium catalyst prepared in situ from RhH(CO)(PPh3)3 and a trans-chelating chiral diphosphine ligand (S,S)-(R,R)-PhTRAP in benzene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdd8bd99d50de4ea9d86de7b1f036c87
https://doi.org/10.1016/s0040-4020(01)89377-7
https://doi.org/10.1016/s0040-4020(01)89377-7
Publikováno v:
ChemInform. 22
The asymmetric aldol reaction of tosylmethyl isocyanide and aldehydes in the presence of 1 mol% of chiral silver(I) catalysts gave optically active 5-alkyl-4-tosyl-2-oxazolines (up to 86% ee), which were converted to optically active α-alkyl-β-(N-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4b6179ea95ec2b0ebdbc3c8cb4e6669
https://doi.org/10.1002/chin.199113091
https://doi.org/10.1002/chin.199113091
Publikováno v:
ChemInform. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbb0ba6b83a1538f15fc3e7a64cdf1ad
https://doi.org/10.1002/chin.199305060
https://doi.org/10.1002/chin.199305060
Publikováno v:
ChemInform. 25
Asymmetric Michael reaction of 2-cyanopropionates with vinyl ketones or acrolein in the presence of 0.1–1 mol% of a rhodium catalyst prepared in situ from RhH(CO)(PPh3)3 and a trans-chelating chiral diphosphine ligand (S,S)-(R,R)-PhTRAP in benzene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3702560e5d078072508b8d0e76bc10f
https://doi.org/10.1002/chin.199433050
https://doi.org/10.1002/chin.199433050