Zobrazeno 1 - 10
of 314
pro vyhledávání: '"Hitoshi, Ando"'
Autor:
Hironao Okubo, Hitoshi Ando, Shunsuke Nakamura, Yusuke Takasaki, Koichi Ito, Yuka Fukuo, Kenichi Ikejima, Hiroyuki Isayama
Publikováno v:
Cancer Medicine, Vol 13, Iss 18, Pp n/a-n/a (2024)
Abstract Aim To investigate the outcomes of cabozantinib in patients with unresectable hepatocellular carcinoma (uHCC), focusing on dose setting and modification. Methods We retrospectively analyzed 34 Japanese patients who received cabozantinib for
Externí odkaz:
https://doaj.org/article/bd189ccd8e1748df98a3f1cc1ca5db23
Autor:
Jun-ichi Morishige, Kazuaki Yoshioka, Hiroki Nakata, Kazuhiro Ishimaru, Naoto Nagata, Tamotsu Tanaka, Yoh Takuwa, Hitoshi Ando
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 11, Pp 100450- (2023)
Sphingosine 1-phosphate (S1P) has been implicated in brown adipose tissue (BAT) formation and energy consumption; however, the mechanistic role of sphingolipids, including S1P, in BAT remains unclear. Here, we showed that, in mice, BAT activation by
Externí odkaz:
https://doaj.org/article/0151fcf1c7854ad28f80e4be25c18b01
Autor:
Ryo Miyazaki, Takafumi Abe, Shozo Yano, Kenta Okuyama, Naoki Sakane, Hitoshi Ando, Minoru Isomura, Masayuki Yamasaki, Toru Nabika
Publikováno v:
Journal of General and Family Medicine, Vol 23, Iss 5, Pp 310-318 (2022)
Abstract Background Living arrangements have been known to be associated with physical frailty. However, the prevalence of frailty and its risk factors in remote islands is not understood. We examined the association between living arrangements and o
Externí odkaz:
https://doaj.org/article/85ae0f47a6f64c15b6a57aabe919bb8c
Autor:
Zheng Jing, Tomohiro Iba, Hisamichi Naito, Pingping Xu, Jun-ichi Morishige, Naoto Nagata, Hironao Okubo, Hitoshi Ando
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Lenvatinib is an oral tyrosine kinase inhibitor that acts on multiple receptors involved in angiogenesis. Lenvatinib is a standard agent for the treatment of several types of advanced cancers; however, it frequently causes muscle-related adverse reac
Externí odkaz:
https://doaj.org/article/76966174080b4fab9b0e1fa79fc45ca8
Autor:
Hironao Okubo, Masanori Atsukawa, Tomomi Okubo, Hitoshi Ando, Eisuke Nakadera, Kenichi Ikejima, Akihito Nagahara
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Glecaprevir is a substrate for organic anion-transporting polypeptide (OATP) 1B1/1B3, which transports bilirubin. Hyperbilirubinemia is an adverse event during anti-hepatitis C virus treatment with glecaprevir and pibrentasvir. Gadoxetic aci
Externí odkaz:
https://doaj.org/article/2165b6a574014f1bbe04bac36519b02b
Autor:
Hironao Okubo, Hitoshi Ando, Kei Ishizuka, Jun-ichi Morishige, Kenichi Ikejima, Shuichiro Shiina, Akihito Nagahara
Publikováno v:
Journal of Pharmacological Sciences, Vol 148, Iss 1, Pp 6-13 (2022)
This prospective study examined the impact of genetic polymorphisms on the pharmacokinetics and clinical efficacy and safety of lenvatinib, a substrate of ATP-binding transporters, in a cohort of 48 Japanese patients with hepatocellular carcinoma (HC
Externí odkaz:
https://doaj.org/article/ca4e65d644cd465c9895d47437e6d33c
Autor:
Hitoshi Ando, Naoto Nagata, Takashi Hosono, Nazmul Hasan, Jun-ichi Morishige, Takiko Daikoku, Yoshiko Maida, Masanori Ono, Tomoko Fujiwara, Hiroshi Fujiwara
Publikováno v:
Frontiers in Nutrition, Vol 9 (2022)
Background and aimCircadian clocks in most peripheral tissues are entrained mainly by feeding. Therefore, this study aimed to investigate whether the daily rhythm of core body temperature (CBT), including the effect of diet-induced thermogenesis, var
Externí odkaz:
https://doaj.org/article/9585b97199d849c1a4f4ddf394025f36
Autor:
Hironao Okubo, Hitoshi Ando, Yusuke Takasaki, Eisuke Nakadera, Yuka Fukuo, Shuichiro Shiina, Kenichi Ikejima
Publikováno v:
Pharmaceuticals, Vol 15, Iss 12, p 1460 (2022)
This prospective study investigated the impact of cabozantinib exposure on proteinuria and muscle toxicity, in a cohort of 14 Japanese patients with unresectable hepatocellular carcinoma (uHCC). We measured the trough concentration of cabozantinib (C
Externí odkaz:
https://doaj.org/article/7c6512e07e88416eb791b58070cf456e
Autor:
Nazmul Hasan, Naoto Nagata, Jun-ichi Morishige, Md Tarikul Islam, Zheng Jing, Ken-ichi Harada, Michihiro Mieda, Masanori Ono, Hiroshi Fujiwara, Takiko Daikoku, Tomoko Fujiwara, Yoshiko Maida, Tsuguhito Ota, Shigeki Shimba, Shuichi Kaneko, Akio Fujimura, Hitoshi Ando
Publikováno v:
Molecular Metabolism, Vol 49, Iss , Pp 101202- (2021)
Objective: Impaired circadian clocks can cause obesity, but their pathophysiological role in brown adipose tissue (BAT), a major tissue regulating energy metabolism, remains unclear. To address this issue, we investigated the effects of complete disr
Externí odkaz:
https://doaj.org/article/4ef08ae78982402b94b53810ee3af358
Autor:
Eri Sagawa, Hironao Okubo, Hitoshi Ando, Yushi Sorin, Ryo Kanazawa, Eisuke Nakadera, Hiroo Fukada, Shigehiro Kokubu, Akihisa Miyazaki
Publikováno v:
Journal of Pharmacological Sciences, Vol 139, Iss 4, Pp 373-376 (2019)
To investigate the relationship between the exposure and efficacy of tolvaptan, we measured pharmacokinetics of total drug at 7 days after repeated doses of 3.75 mg/day tolvaptan in 16 patients with hepatic edema. Nine patients (56.3%) were responder
Externí odkaz:
https://doaj.org/article/df7951eb884045a784ff180e7de1f727