Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Hitoo Nishi"'
Autor:
Takahiro Horie, Tetsushi Nakao, Yui Miyasaka, Tomohiro Nishino, Shigenobu Matsumura, Fumiko Nakazeki, Yuya Ide, Masahiro Kimura, Shuhei Tsuji, Randolph Ruiz Rodriguez, Toshimitsu Watanabe, Tomohiro Yamasaki, Sijia Xu, Chiharu Otani, Sawa Miyagawa, Kazuki Matsushita, Naoya Sowa, Aoi Omori, Jin Tanaka, Chika Nishimura, Masataka Nishiga, Yasuhide Kuwabara, Osamu Baba, Shin Watanabe, Hitoo Nishi, Yasuhiro Nakashima, Marina R. Picciotto, Haruhisa Inoue, Dai Watanabe, Kazuhiro Nakamura, Tsutomu Sasaki, Takeshi Kimura, Koh Ono
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Adaptive thermogenesis is regulated by central neuronal circuits. Here, the authors show that microRNA-33 in the brain contributes to the maintenance of brown adipose tissue thermogenesis and whole-body energy balance via enhanced sympathetic nerve t
Externí odkaz:
https://doaj.org/article/8523a0051c014923987d8a460a8d8a1f
Autor:
Yuya Ide, MD, Takahiro Horie, MD, PhD, Naritatsu Saito, MD, PhD, Shin Watanabe, MD, PhD, Chiharu Otani, MD, Yui Miyasaka, BSc, Yasuhide Kuwabara, MD, PhD, Tomohiro Nishino, MD, PhD, Tetsushi Nakao, MD, PhD, Masataka Nishiga, MD, PhD, Hitoo Nishi, MD, PhD, Yasuhiro Nakashima, MD, PhD, Fumiko Nakazeki, MD, PhD, Satoshi Koyama, MD, PhD, Masahiro Kimura, MD, Shuhei Tsuji, MD, Randolph Ruiz Rodriguez, MD, Sijia Xu, MD, Tomohiro Yamasaki, MD, Toshimitsu Watanabe, MD, Masamichi Yamamoto, PhD, Motoko Yanagita, MD, PhD, Takeshi Kimura, MD, PhD, Akira Kakizuka, MD, PhD, Koh Ono, MD, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 4, Iss 6, Pp 701-714 (2019)
Summary: No effective treatment is yet available to reduce infarct size and improve clinical outcomes after acute myocardial infarction by enhancing early reperfusion therapy using primary percutaneous coronary intervention. The study showed that Kyo
Externí odkaz:
https://doaj.org/article/d66cbcb274f6484fb40460d224a0132a
Autor:
Ada Weinstock, Karishma Rahman, Or Yaacov, Hitoo Nishi, Prashanthi Menon, Cyrus A Nikain, Michela L Garabedian, Stephanie Pena, Naveed Akbar, Brian E Sansbury, Sean P Heffron, Jianhua Liu, Gregory Marecki, Dawn Fernandez, Emily J Brown, Kelly V Ruggles, Stephen A Ramsey, Chiara Giannarelli, Matthew Spite, Robin P Choudhury, P'ng Loke, Edward A Fisher
Publikováno v:
eLife, Vol 10 (2021)
Atherosclerosis is a disease of chronic inflammation. We investigated the roles of the cytokines IL-4 and IL-13, the classical activators of STAT6, in the resolution of atherosclerosis inflammation. Using Il4-/-Il13-/- mice, resolution was impaired,
Externí odkaz:
https://doaj.org/article/c161388cdc5a4ae69a76b07070902db1
Autor:
Satoshi Koyama, Takahiro Horie, Tomohiro Nishino, Osamu Baba, Naoya Sowa, Yui Miyasaka, Yasuhide Kuwabara, Tetsushi Nakao, Masataka Nishiga, Hitoo Nishi, Yasuhiro Nakashima, Fumiko Nakazeki, Yuya Ide, Masahiro Kimura, Shuhei Tsuji, Randolph Ruiz Rodriguez, Sijia Xu, Tomohiro Yamasaki, Chiharu Otani, Toshimitsu Watanabe, Tomoyuki Nakamura, Koji Hasegawa, Takeshi Kimura, Koh Ono
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 13 (2019)
Background MicroRNA (miR)‐33 targets cholesterol transporter ATP‐binding cassette protein A1 and other antiatherogenic targets and contributes to atherogenic progression. Its inhibition or deletion is known to result in the amelioration of athero
Externí odkaz:
https://doaj.org/article/69648184ded84dff81452fbc1f678cd7
Autor:
Michael Peled, Hitoo Nishi, Ada Weinstock, Tessa J Barrett, Felix Zhou, Alexandra Quezada, Edward A Fisher
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173975 (2017)
Atherosclerosis can be induced by the injection of a gain-of-function mutant of proprotein convertase subtilisin/kexin type 9 (PCSK9)-encoding adeno-associated viral vector (AAVmPCSK9), avoiding the need for knockout mice models, such as low-density
Externí odkaz:
https://doaj.org/article/e22b88b89f024f4a956b9c97cb2c18fb
Autor:
Takahiro Horie, Koh Ono, Minako Kinoshita, Hitoo Nishi, Kazuya Nagao, Teruhisa Kawamura, Yukiko Abe, Hiromichi Wada, Akira Shimatsu, Toru Kita, Koji Hasegawa
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 6, Pp 1224-1234 (2008)
The accumulation of visceral adipose tissue is closely associated with insulin resistance and metabolic syndrome. Therefore, it is important to identify genes that are required for adipocyte differentiation. To identify genes that are required for th
Externí odkaz:
https://doaj.org/article/43ee318aba0941e59c701fc84dfd0adc
Autor:
Elina Shrestha, Maud Voisin, Tessa J. Barrett, Hitoo Nishi, Inés Pineda-Torra, Edward A. Fisher, Michael J. Garabedian
Publikováno v:
Journal of Clinical and Translational Science, Vol 1, Pp 5-5 (2017)
OBJECTIVES/SPECIFIC AIMS: Accumulation of cholesterol-laden macrophages in arterial walls leads to atherosclerosis. LXRs induce expression of genes that are atheroprotective in macrophages including CCR7, a chemokine receptor that promotes their emig
Externí odkaz:
https://doaj.org/article/cfe80064bf7b488eb97efc0ccebba3c7
Autor:
Shin Watanabe, Takahiro Horie, Kazuya Nagao, Yasuhide Kuwabara, Osamu Baba, Hitoo Nishi, Naoya Sowa, Michiko Narazaki, Tetsuya Matsuda, Genzou Takemura, Hiromichi Wada, Koji Hasegawa, Takeshi Kimura, Koh Ono
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e108201 (2014)
The mechanism of cardiac energy production against sustained pressure overload remains to be elucidated.We generated cardiac-specific kinase-dead (kd) calcium/calmodulin-dependent protein kinase kinase-β (CaMKKβ) transgenic (α-MHC CaMKKβkd TG) mi
Externí odkaz:
https://doaj.org/article/ecc13d2be7d642a299af22c245b5f04f
Autor:
Tiit Örd, Minna U. Kaikkonen, Hitoo Nishi, Casey E. Romanoski, Edward A. Fisher, Kadri Õunap, Austin C. Conklin, Florencia Schlamp
Publikováno v:
Immunometabolism
Background: Vascular smooth muscle cells (VSMC) exhibit phenotypic plasticity in atherosclerotic plaques, and among other approaches, has been modeled in vitro by cholesterol loading. Methods: Meta-analysis of scRNA-seq data from VSMC lineage traced
Autor:
Randolph Ruiz Rodriguez, Fumiko Nakazeki, Takeshi Kimura, Chiharu Otani, Yuya Ide, Sijia Xu, Takahiro Horie, Akira Kakizuka, Toshimitsu Watanabe, Koh Ono, Yui Miyasaka, Satoshi Koyama, Yasuhide Kuwabara, Naritatsu Saito, Masamichi Yamamoto, Tomohiro Nishino, Shin Watanabe, Yasuhiro Nakashima, Tomohiro Yamasaki, Masahiro Kimura, Hitoo Nishi, Motoko Yanagita, Masataka Nishiga, Shuhei Tsuji, Tetsushi Nakao
Publikováno v:
JACC: Basic to Translational Science, Vol 4, Iss 6, Pp 701-714 (2019)
JACC: Basic to Translational Science
JACC: Basic to Translational Science
Visual Abstract
Highlights • KUS121 was developed to selectively inhibit the adenosine triphosphatase activity of valosin-containing protein without affecting other cellular functions of valosin-containing protein. • KUS121 preserved adenosi
Highlights • KUS121 was developed to selectively inhibit the adenosine triphosphatase activity of valosin-containing protein without affecting other cellular functions of valosin-containing protein. • KUS121 preserved adenosi