Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Hitoo Iwase"'
Autor:
Hiroko Odani, Shigeru Nakai, Hitoo Iwase, Makoto Tomita, Yoshiyuki Hiki, Kunihiro Nabeshima, Kazuo Takahashi, Sachiko Shimozato, Isao Ishida, Kazutaka Murakami, Kouichirou Yamamoto, Yoshiroh Fujita, Satoshi Sugiyama, Midori Hasegawa
Publikováno v:
Clinical and Experimental Nephrology. 12:20-27
The KM mouse lacks endogenous genes for immunoglobulins and carries the entire human IgH locus and the IgLk transgene. Therefore, human IgA1 does not provoke a hetero-immune response. We had observed mesangial IgA deposits in KM mice given desialo-de
Publikováno v:
Auris Nasus Larynx. 34:1-4
Objective Geranylgeranylacetone (GGA), an anti-ulcer drug, has been reported to induce heat shock proteins (HSPs) in several animal organs. Purpose of this study was to investigate whether GGA has protective effect on gentamycin (GM) ototoxicity and
Autor:
Hiroko Odani, Satoshi Sugiyama, Hitoo Iwase, Nobuteru Usuda, Sachiko Shimozato, Kazuo Takahashi, Yoshiyuki Hiki
Publikováno v:
Biochemical and Biophysical Research Communications. 350:580-587
The aim of the study was to develop a simple and precise method for identifying glycosylation of the IgA hinge region using surface-enhanced laser desorption/ionization (SELDI)-TOFMS with a lectin-coupled ProteinChip array. Serum IgA was isolated usi
Publikováno v:
Acta Oto-Laryngologica. 124:28-31
Human immunoglobulin A1 (IgA1), which is the predominant subtype to be deposited in glomeruli in IgA nephropathy (IgAN), has a unique mucine-like structure in its hinge region. Namely, it contains ...
Autor:
Yutaka Kobayashi, Hiroko Odani, Kenji Maeda, Mami Takahashi, Hitoo Iwase, Yoshiyuki Hiki, Yoshinari Yasuda, Masashi Kato, Akeyo Horie, Izumi Nakashima
Publikováno v:
American Journal of Kidney Diseases. 42:486-496
Background: Human serum immunoglobulin A1 (IgA1) has a unique mucine-like structure in its hinge region that contains O -glycans and proline-rich peptides. We previously reported the under- O -glycosylation of the hinge in serum IgA1 and deposited Ig
Autor:
Kazunori Toma, Tohru Kokubo, Kenjiro Hashizume, Kenji Arai, Yutaka Kobayashi, Hitoo Iwase, Atsushi Tanaka, Kyoko Hotta
Publikováno v:
Nephrology Dialysis Transplantation. 15:28-33
Background. The human IgA1 hinge region is a unique mucin-like O-linked proline-rich glycopeptide, and its core peptide was found to be exposed aberrantly by the underglycosylation in IgA nephropathy (IgAN ). Introduction We describe here the presenc
Autor:
Hitoo Iwase
Publikováno v:
Trends in Glycoscience and Glycotechnology. 21:247-249
Autor:
Yuhichiro Yokozeki, Ikuko Ishii-Karakasa, Yutaka Kobayashi, Kyoko Hotta, Tohru Kokubo, Yoshiyuki Hiki, Hitoo Iwase, Atsushi Tanaka, Kunio Hisatani, Takashi Sano
Publikováno v:
Biochemical and Biophysical Research Communications. 264:424-429
As we reported before, exoglycosidase treatment of human serum IgA1 changed it to a sticky molecule. In order to examine the presence of the specific binding protein to the sticky IgA1 in human serum, IgA1, asialo-IgA1 (IgA1-S) and asialo-, agalacto-
Autor:
Kazunori Toma, Yutaka Kobayashi, Kyoko Hotta, Yoshihiko Masaki, Hitoo Iwase, Yoshiyuki Hiki, Atsushi Tanaka, Takashi Sano, Tohru Kokubo
Publikováno v:
Journal of the American Society of Nephrology. 10:760-769
This study was performed to isolate and investigate the IgA1 that could accumulate in glomeruli (glomerulophilic IgA1). IgA1 was fractionated by the electric charge and the reactivity to Jacalin. Serum IgA1 of IgA nephropathy patients was separated a