Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Hitomi Hiratani"'
Autor:
Roubila Meziani, Ryo Yamada, Meiko Takahashi, Kenei Ohigashi, Akio Morinobu, Chikashi Terao, Hitomi Hiratani, Koichiro Ohmura, Masao Yamaguchi, Takashi Nomura, Alexandre Vasilescu, Miki Kokubo, Victor Renault, Katsura Hirosawa, Chanavee Ratanajaraya, Simon Heath, Tsuneyo Mimori, Shimon Sakaguchi, Mark Lathrop, Inga Melchers, Shunichi Kumagai, Fumihiko Matsuda
Publikováno v:
Modern Rheumatology. 22:52-58
Autor:
Miki Kokubo, Chikashi Terao, Simon Heath, Masao Yamaguchi, Shimon Sakaguchi, Tsuneyo Mimori, Akio Morinobu, Ryo Yamada, Meiko Takahashi, Takashi Nomura, Chanavee Ratanajaraya, Katsura Hirosawa, Koichiro Ohmura, Shunichi Kumagai, Roubila Meziani, Hitomi Hiratani, Inga Melchers, Victor Renault, Fumihiko Matsuda, Kenei Ohigashi, Mark Lathrop, Alexandre Vasilescu
Publikováno v:
Modern Rheumatology. 22:52-58
Rheumatoid arthritis (RA) is a common systemic autoimmune disease and its onset and prognosis are controlled by genetic, immunological, and environmental factors. The HLA locus, particularly HLA-DRB1, is its strongest genetic risk determinant across
Autor:
Emma I. Chistiakova, Yoshio Ban, Tomasz Bednarczuk, Rue-Tsuan Liu, Shigehiro Katayama, Lidia Karabon, Takuya Awata, Fotini K. Kavvoura, Susumu Kurihara, Stephen C. L. Gough, Ikuyo Miyake, Marcin Chojm, Matsuo Taniyama, Suh-Hang Hank Juo, Abbas Ghaderi, Edyta Pawlak, Irena Frydecka, John P. A. Ioannidis, Dimitry A. Chistiakov, Pei-Wen Wang, Yuji Hiromatsu, Hitomi Hiratani, Teruaki Tozaki, Joanne M. Heward, Gholamhossein Ranjbar Omrani, Takashi Akamizu, Yoshiyuki Ban, Rafał Płoski
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 92:3162-3170
CONTEXT: Cytotoxic T-lymphocyte associated antigen 4 (CTLA-4) polymorphisms have been widely examined for their associations with autoimmune thyroid diseases [Graves' disease (GD) and Hashimoto thyroiditis (HT)], but their relative population effect
Autor:
Nagahisa Yoshimura, Hitomi Hiratani, Marion Monet, Sachiko Kuroiwa, Sachiko Toyoda, Shohei Chida, Fumihiko Matsuda, Atsushi Otani, Victor Renault, Norimoto Gotoh, Michiko Mandai, Ryo Yamada
Publikováno v:
Human Genetics. 120:139-143
Age-related macular degeneration (ARMD) is the leading cause of blindness in the elderly population not only Western but also Asian industrial countries. In Caucasian, a polymorphism of the complement factor H gene (CFH), the C allele of rs1061170 (Y
Autor:
Kenji Moriyama, Takashi Akamizu, Yuji Hataya, Kazuwa Nakao, Yushu Li, Naotetsu Kanamoto, Hitomi Hiratani
Publikováno v:
Endocrinology. 145:2524-2530
The expression of major histocompatibility complex (MHC) class II molecules on thyrocytes has been demonstrated in autoimmune thyroid diseases. However, the role of this aberrant MHC class II in disease development is controversial. In particular, it
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 85:2116-2121
Blocking-type TSH-binding inhibitor Igs (TBIIs) are known to cause hypothyroidism and an atrophic thyroid gland in patients with primary myxedema. They can block the activity of thyroid-stimulating antibodies (TSAbs) in Graves' patients as well as th
Autor:
Koichi Ito, Naofumi Ishikawa, Takashi Akamizu, Hajime Tamai, Senji Shirasawa, Kunihiko Ito, Masao Tanaka, Hitomi Hiratani, Koichi Furugaki, Kanji Kuma, Takehiko Sasazuki, Sumihisa Kubota
Publikováno v:
Journal of Human Genetics. 49:166-168
Autoimmune thyroid disease (AITD) is caused by an immune response to self-thyroid antigen. The cytotoxic T-lymphocyte antigen-4 ( CTLA4) gene, encoding a negative regulator of the T-lymphocyte immune response, had been reported to be associated and/o
Autor:
Hitomi Hiratani, Akira Shimizu, Takashi Akamizu, Senji Shirasawa, Yoshinori Iwatani, Donald W. Bowden, Satoshi Ikegami
Publikováno v:
The Journal of clinical endocrinology and metabolism. 90(5)
Our previous studies using microsatellite markers near or in the TSH receptor (TSHR) gene revealed significant association between autoimmune thyroid disease (AITD) in Japanese patients and TSHR microsatellite alleles. In the present study, we perfor
Autor:
Koichi Ito, Ken Yamamoto, Hitomi Hiratani, Haruhito Harada, Takehiko Sasazuki, Mayuko Ishikawa, Masayuki Aoki, Koichi Furugaki, Kanji Kuma, Masao Tanaka, Naofumi Ishikawa, Takashi Akamizu, Iwai Baba, Kunihiko Ito, Hajime Tamai, Senji Shirasawa, Kenji Sakai, Tomoko Tsuchiya, Sumihisa Kubota
Publikováno v:
Human molecular genetics. 13(19)
Autoimmune thyroid disease (AITD) is caused by an immune response to self-thyroid antigens and has a significant genetic component. Antisense RNA transcripts have been implicated in gene regulation. Here we have identified a novel zinc-finger gene, d