Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Hitomi Fushida"'
Autor:
Katsumi Miyazaki, Keishiro Miyake, Aki Nakai, Hitomi Fushida, Takaichi Arita, Mayumi Nishikata, Ken Iseki
Publikováno v:
Journal of Pharmacy and Pharmacology. 46:591-595
Concentrations of homochlorcyclizine enantiomers in blood, urine, and tissues of the liver, lung, kidney, brain, heart, spleen, intestine and stomach of rats after drug administration were determined by high-performance liquid chromatography on a chi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50a45ee93f2a0a41d1da16396511e990
https://doi.org/10.1111/j.2042-7158.1994.tb03863.x
https://doi.org/10.1111/j.2042-7158.1994.tb03863.x
Autor:
Mayumi Nishikata, Keishiro Miyake, Ken Iseki, Takaichi Arita, Katsumi Miyazaki, Hitomi Fushida, Aki Nakai
Publikováno v:
Biological and Pharmaceutical Bulletin. 17:1267-1271
The enantioselective relationship between the pharmacokinetics and hepatic metabolism of homochlorcyclizine hydrochloride (HCZ) was investigated using rats. There were no significant differences in blood concentrations between the three forms after i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acca1e1ddd182fc67c56769e3f1be67e
https://doi.org/10.1248/bpb.17.1267
https://doi.org/10.1248/bpb.17.1267
Autor:
Keishiro Miyake, Aki Nakai, Akikazu Nomura, Hitomi Fushida, Takaichi Arita, Katsumi Miyazaki, Ken Iseki, Mayumi Nishikata
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 612:239-244
A method is described for the simultaneous determination of (+)- and (−)-homochlorcyclizine (HCZ) in human urine by high-performance liquid chromatography on a chiral stationary phase of ovomucoid-bonded silica. The pH of the buffer and organic mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61da813ae20ce89506e1b83cf1cff314
https://doi.org/10.1016/0378-4347(93)80169-5
https://doi.org/10.1016/0378-4347(93)80169-5
Autor:
Keishiro Miyake, Mayumi Nishikata, Ken Iseki, Akikazu Nomura, Aki Nakai, Takaichi Arita, Hitomi Fushida, Katsumi Miyazaki
Publikováno v:
European journal of clinical pharmacology. 43(5)
The pharmacokinetics of a single oral dose of 20 mg (+)-, (-)- and racemic homochlorcyclizine (HCZ) have been studied in humans. The formation of the quarternary ammonium-linked glucuronide was an important metabolic pathway, and the metabolic proces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::014cfb82de78e827713564a5bf9b5773
https://pubmed.ncbi.nlm.nih.gov/1362384
https://pubmed.ncbi.nlm.nih.gov/1362384
Autor:
Ken Iseki, Mayumi Nishikata, Satomi Kitagawa, Aki Nakai, Keishiro Miyake, Takaichi Arita, Katsumi Miyazaki, Masaru Kunitomo, Hitomi Fushida
Publikováno v:
Chemical and Pharmaceutical Bulletin. 40:1341-1342
A method was developed for semi-preparative scale enantioseparation of racemic homochlorcyclizine (HCZ) by high performance liquid chromatography (HPLC) on Chiralcel OD column. The best resolution was achieved using an eluent composed of n-hexane plu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15261bfe2cc03b4560f1028c5a04b52e
https://doi.org/10.1248/cpb.40.1341
https://doi.org/10.1248/cpb.40.1341