Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Hitomi Akazawa"'
Autor:
Naoki Amada, Hitomi Akazawa, Yuta Ohgi, Kenji Maeda, Haruhiko Sugino, Nobuyuki Kurahashi, Tetsuro Kikuchi, Takashi Futamura
Publikováno v:
Neuropsychopharmacology Reports, Vol 39, Iss 4, Pp 279-288 (2019)
Abstract Background Long‐term antipsychotic treatment in patients with schizophrenia can induce supersensitivity psychosis and tardive dyskinesia which is thought to be caused by dopamine D2 receptor sensitization. We evaluated the effects of brexp
Externí odkaz:
https://doaj.org/article/66b91c71c5e2434aa05a0dc090222e04
Autor:
Nobuyuki Kurahashi, Naoki Amada, Hitomi Akazawa, Tetsuro Kikuchi, Haruhiko Sugino, Takashi Futamura, Yuta Ohgi, Kenji Maeda
Publikováno v:
Neuropsychopharmacology Reports. 39:279-288
Background Long-term antipsychotic treatment in patients with schizophrenia can induce supersensitivity psychosis and tardive dyskinesia which is thought to be caused by dopamine D2 receptor sensitization. We evaluated the effects of brexpiprazole on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::895067ec7a745fe4448504b028a5ec5a
https://doi.org/10.1002/npr2.12076
https://doi.org/10.1002/npr2.12076
Autor:
Hiroyuki Sasabe, Yosuke Kaneko, Masayuki Furukawa, Masayuki Matsunaga, Eiji Kashiyama, Yukihiro Hirao, Mitsuhiko Kawabata, Noriyuki Koyama, Toshihisa Koga, Hitomi Akazawa, Kenji Takeuchi
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 51(5)
The pharmacokinetics of brexpiprazole were investigated in the in vitro and in vivo.The total body clearance of brexpiprazole in rat and monkey was 2.32 and 0.326 L/h/kg, respectively, after intrav...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab7762bcff7a84c2ea001970b465d606
https://pubmed.ncbi.nlm.nih.gov/33685346
https://pubmed.ncbi.nlm.nih.gov/33685346
Autor:
Nobuaki Ito, Robert D. McQuade, Christoffer Bundgaard, Hiroshi Yamashita, Hitomi Akazawa, Arne Mørk, Takashi Futamura, Alan L. Pehrson, Kenji Maeda, Tetsuro Kikuchi, Tine B. Stensbøl, Jørn Arnt, Naoki Amada, Haruhiko Sugino, Morten Hentzer, Jun Shimada, Vibeke Nielsen
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 350:589-604
Brexpiprazole (OPC-34712, 7-{4-[4-(1-benzothiophen-4-yl)piperazin-1-yl]butoxy}quinolin-2(1H)-one) is a novel drug candidate in clinical development for psychiatric disorders with high affinity for serotonin, dopamine, and noradrenaline receptors. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57d9c2e766832864e11e611f96ebc543
https://doi.org/10.1124/jpet.114.213793
https://doi.org/10.1124/jpet.114.213793
Autor:
Tine B. Stensbøl, Christoffer Bundgaard, Naoki Amada, Haruhiko Sugino, Jørn Arnt, Kenji Maeda, Tetsuro Kikuchi, Hitomi Akazawa, Robert D. McQuade, Linda Lerdrup
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 350(3)
Brexpiprazole (OPC-34712, 7-{4-[4-(1-benzothiophen-4-yl)piperazin-1-yl]butoxy}quinolin-2(1H)-one) is a novel serotonin-dopamine activity modulator with partial agonist activity at serotonin 1A (5-HT1A) and D2/3 receptors, combined with potent antagon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbf7923d89da5952c45e2f494a3419b4
https://pubmed.ncbi.nlm.nih.gov/24947464
https://pubmed.ncbi.nlm.nih.gov/24947464
Autor:
Hitomi Akazawa
Publikováno v:
Zeitschrift der Japanischen Mikrobiologische Gesellschaft. 37:150-160
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::096c849d382592868f4f83c63bf6cb7c
https://doi.org/10.3412/jsb1928.37.150
https://doi.org/10.3412/jsb1928.37.150
Autor:
Masuo Kudo, Hitomi Akazawa
Publikováno v:
Zeitschrift der Japanischen Mikrobiologische Gesellschaft. 35:1081-1094
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::873133cf28dc1141334885bf0b871df8
https://doi.org/10.3412/jsb1928.35.1081
https://doi.org/10.3412/jsb1928.35.1081
Autor:
Itsuo Hamada, Hitomi Akazawa
Publikováno v:
Zeitschrift der Japanischen Mikrobiologische Gesellschaft. 32:461-468
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8ec7f73f70ee6437d2d03fd5e822253
https://doi.org/10.3412/jsb1928.32.461
https://doi.org/10.3412/jsb1928.32.461
Autor:
Itsuo Hamada, Hitomi Akazawa
Publikováno v:
Zeitschrift der Japanischen Mikrobiologische Gesellschaft. 32:1260-1268
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6512640eec04691def7aaeb2eff0cc16
https://doi.org/10.3412/jsb1928.32.1260
https://doi.org/10.3412/jsb1928.32.1260
Publikováno v:
Zeitschrift der Japanischen Mikrobiologische Gesellschaft. 34:422-431
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4734f0d06b9888bd03f61937b948bfe
https://doi.org/10.3412/jsb1928.34.422
https://doi.org/10.3412/jsb1928.34.422