Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Hitomi, Ohta"'
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30007 (2012)
Beta-amyloid (Aβ) peptides are considered to play a major role in the pathogenesis of Alzheimer's disease (AD) and molecules that can prevent pathways of Aβ toxicity may be potential therapeutic agents for treatment of AD. We have previously report
Externí odkaz:
https://doaj.org/article/bdf5f9acce5d451a9d072326eda58eab
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e17137 (2011)
BACKGROUND: Neurotrophic factors may be future therapeutic agents for neurodegenerative disease. In the screening of biologically active molecules for neurotrophic potency, we found that a photosensitizing cyanine dye, NK-4, had remarkable neurotroph
Externí odkaz:
https://doaj.org/article/629e93d203294d4d835dcdd8b86bc9b0
Autor:
Hitomi Ohta, Tsunetaka Ohta, Shigeharu Fukuda, Satomi Koya-Miyata, Toshio Kawata, Kenji Akita, Shigeyuki Arai
Publikováno v:
Biological and Pharmaceutical Bulletin. 33:1872-1877
Some photosensitizing cyanine dyes act on the immune system to enhance the phagocytic capacity of macrophages. In this study, we examined whether these dyes have neurotrophin-like activities and neuroprotective effects in vitro and in vivo. By screen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::101c799c6fd8e30cc609ea3ee56b2931
https://doi.org/10.1248/bpb.33.1872
https://doi.org/10.1248/bpb.33.1872
Autor:
Hitomi Ohta, Chie Ushio, Tsunetaka Ohta, Harumi Ariyasu, Shigeharu Fukuda, Masashi Kurimoto, Toshio Ariyasu, Tohru Kayano, Miho Aga
Publikováno v:
Journal of Interferon & Cytokine Research. 28:359-366
In the present study, we describe the generation of a series of anti-interferon-alpha8 (IFN-alpha8)-specific monoclonal antibodies (mAbs), their characterization, and the establishment of a sandwich enzyme-linked immunosorbent assay (ELISA) system fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13f5c06975f3e13e110b738961d63354
https://doi.org/10.1089/jir.2007.0121
https://doi.org/10.1089/jir.2007.0121
Autor:
Shigeharu Fukuda, Tsunetaka Ohta, Hitomi Ohta, Shigeyuki Arai, Toshiharu Hanaya, Iwao Okamoto
Publikováno v:
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 143:484-491
Mammalian hibernators are considered a natural model for resistance to ischemia-reperfusion injuries, and protective mechanisms against oxidative stress evoked by repeated hibernation-arousal cycles in these animals are increasingly the focus of expe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e778b0bd001b1ba7ded4e51d2201cf1
https://doi.org/10.1016/j.cbpc.2006.05.002
https://doi.org/10.1016/j.cbpc.2006.05.002
Publikováno v:
Oxidative Stress-Environmental Induction and Dietary Antioxidants
Cyanine photosensitizing dyes have been studied for over 150 years and continue to be of interest in their biology and medicine. They have been shown to possess various biological activities, including antimicrobial, antioxidant, macrophage activatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24e1a2b5dd4cf73261ac381da309cd95
http://www.intechopen.com/articles/show/title/effects-of-nk-4-a-cyanine-dye-with-antioxidant-activities-attenuation-of-neuronal-deficits-in-ani
http://www.intechopen.com/articles/show/title/effects-of-nk-4-a-cyanine-dye-with-antioxidant-activities-attenuation-of-neuronal-deficits-in-ani
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 1, p e30007 (2012)
PLoS ONE, Vol 7, Iss 1, p e30007 (2012)
Beta-amyloid (Aβ) peptides are considered to play a major role in the pathogenesis of Alzheimer's disease (AD) and molecules that can prevent pathways of Aβ toxicity may be potential therapeutic agents for treatment of AD. We have previously report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3147068257e83421400dd6c9619d3ad6
https://pubmed.ncbi.nlm.nih.gov/22238689
https://pubmed.ncbi.nlm.nih.gov/22238689
Publikováno v:
PLoS ONE
PLoS ONE, Vol 6, Iss 2, p e17137 (2011)
PLoS ONE, Vol 6, Iss 2, p e17137 (2011)
BACKGROUND: Neurotrophic factors may be future therapeutic agents for neurodegenerative disease. In the screening of biologically active molecules for neurotrophic potency, we found that a photosensitizing cyanine dye, NK-4, had remarkable neurotroph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd9caefdb3e5e18c14afe685c7741799
https://pubmed.ncbi.nlm.nih.gov/21347252
https://pubmed.ncbi.nlm.nih.gov/21347252
Publikováno v:
Alzheimer's & Dementia. 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::895aa50ea788821cb8055d6d63b8642a
https://doi.org/10.1016/j.jalz.2010.05.1938
https://doi.org/10.1016/j.jalz.2010.05.1938
Autor:
Hitomi, Ohta, Tadao, Tanimoto, Madoka, Taniai, Mutsuko, Taniguchi, Toshio, Ariyasu, Shigeyuki, Arai, Tsunetaka, Ohta, Shigeharu, Fukuda
Publikováno v:
In vivo (Athens, Greece). 21(1)
Endogenous tumor necrosis factor-alpha (TNF-alpha) has a beneficial effect as an activation mediator of host defense against infection by the fungus Candida albicans (C. albicans). However, it is unclear whether exogenous TNF-alpha has a beneficial o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::82ea076797f7f23348dd6c7cd7545420
https://pubmed.ncbi.nlm.nih.gov/17354610
https://pubmed.ncbi.nlm.nih.gov/17354610