Výsledky vyhledávání - "Hitomi, Motomura"

Akademický článek

High expression of SLC20A1 is less effective for endocrine therapy and predicts late recurrence in ER-positive breast cancer.

Autor: Chotaro Onaga, Shoma Tamori, Izumi Matsuoka, Ayaka Ozaki, Hitomi Motomura, Yuka Nagashima, Tsugumichi Sato, Keiko Sato, Yuyun Xiong, Kazunori Sasaki, Shigeo Ohno, Kazunori Akimoto

Publikováno v: PLoS ONE, Vol 17, Iss 5, p e0268799 (2022)

Estrogen receptor-positive (ER+) breast cancer intrinsically confers satisfactory clinical outcomes in response to endocrine therapy. However, a significant proportion of patients with ER+ breast cancer do not respond well to this treatment. Therefor

Externí odkaz: https://doaj.org/article/e9147898669549f3baefc812aae176a9

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Akademický článek

High PKCλ expression is required for ALDH1-positive cancer stem cell function and indicates a poor clinical outcome in late-stage breast cancer patients.

Autor: Yuka Nozaki, Hitomi Motomura, Shoma Tamori, Yumiko Kimura, Chotaro Onaga, Shotaro Kanai, Yuka Ishihara, Ayaka Ozaki, Yasushi Hara, Yohsuke Harada, Yasunari Mano, Tsugumichi Sato, Keiko Sato, Kazunori Sasaki, Hitoshi Ishiguro, Shigeo Ohno, Kazunori Akimoto

Publikováno v: PLoS ONE, Vol 15, Iss 7, p e0235747 (2020)

Despite development of markers for identification of cancer stem cells, the mechanism underlying the survival and division of cancer stem cells in breast cancer remains unclear. Here we report that PKCλ expression was enriched in basal-like breast c

Externí odkaz: https://doaj.org/article/b04cfed37c1b4f8ab79263c66008449a

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GLO 1 and PKCλ Regulate ALDH1-positive Breast Cancer Stem Cell Survival

Autor: Tsugumichi Sato, Kazunori Sasaki, Ayano Namiki, Keiko Sato, Shigeo Ohno, Shoma Tamori, Yuyun Xiong, Yohsuke Harada, Yasushi Hara, Masa-Aki Yatani, Yasunari Mano, Ryoko Takasawa, Kazunori Akimoto, Hitomi Motomura, Chotaro Onaga, Ayaka Ozaki, Sei-ichi Tanuma, Takehisa Hanawa

Publikováno v: Anticancer Research. 41:5959-5971

BACKGROUND/AIM We examined the inhibitory effects of both glyoxalase 1 (GLO 1) and protein kinase C (PKC)λ in aldehyde dehydrogenase 1 (ALDH1)-positive breast cancer stem cells (CSCs). MATERIALS AND METHODS Breast cancer genomics datasets (TCGA, n=5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3880f2383483738d1449ff26592967bc
https://doi.org/10.21873/anticanres.15415

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High Expression of

Autor: Yuyun, Xiong, Hitomi, Motomura, Shoma, Tamori, Ayaka, Ozaki, Chotaro, Onaga, Yasushi, Hara, Keiko, Sato, Kouji, Tahata, Yohsuke, Harada, Kazunori, Sasaki, Yun-Wen, Zheng, Shigeo, Ohno, Kazunori, Akimoto

Publikováno v: Anticancer research. 42(11)

CD58 is an immune adhesion molecule on the cellular surface. It was previously found that a high expression of CD58 predicted a poor prognosis of patients with lower-grade gliomas. Therefore, the aim of this paper was to investigate the association b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d6ad1583ccc6554bf42889bfdcf1071b
https://pubmed.ncbi.nlm.nih.gov/36288878

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High SLC20A1 Expression Is Associated With Poor Prognosis for Radiotherapy of Estrogen Receptor-positive Breast Cancer

Autor: CHOTARO ONAGA, SHOMA TAMORI, IZUMI MATSUOKA, AYAKA OZAKI, HITOMI MOTOMURA, YUKA NAGASHIMA, TSUGUMICHI SATO, KEIKO SATO, KOUJI TAHATA, YUYUN XIONG, YOSHIO NAKANO, YASUNARI MANO, SATORU MIYAZAKI, KAZUNORI SASAKI, SHIGEO OHNO, KAZUNORI AKIMOTO

Publikováno v: Cancer Diagn Progn

Background/Aim: Radiotherapy is one of the main treatments for estrogen receptor-positive (ER+) breast cancer. However, in some ER+ breast cancer cases, radiotherapy is insufficient to inhibit progression and there is a lack of markers to predict rad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3106415d3b5bda8a86fa47c90f395d44
https://europepmc.org/articles/PMC9254097/

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High Expression of

Publikováno v: Anticancer research. 42(7)

p62 (also known as sequestosome 1) is involved in cancer progression, and high expression of p62 indicates poor clinical outcome in several cancer types. However, the association between p62 gene expression and cancer stem cells (CSCs) in breast canc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d0e99948b8a2a33292511be68df3b480
https://pubmed.ncbi.nlm.nih.gov/35790283

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High Expression of c-Met, PKCλ and ALDH1A3 Predicts a Poor Prognosis in Late-stage Breast Cancer

Autor: Chotaro Onaga, Yasunari Mano, Ayaka Ozaki, Yuka Nozaki, Shotaro Kanai, Chihiro Ohira, Shoma Tamori, Yohsuke Harada, Tsugumichi Sato, Keiko Sato, Yasushi Hara, Taka Aki Shiina, Ryoko Takasawa, Kazunori Akimoto, Sei-ichi Tanuma, Takehisa Hanawa, Hitomi Motomura

Publikováno v: Anticancer Research. 40:35-52

Background/aim Co-expression of c-Met and ALDH1A3 indicates a poor prognosis in stage III-IV breast cancers and contributes to cell proliferation and tumor formation by ALDH1-positive breast CSCs. PKCλ is overexpressed and contributes to a poor prog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b7a924b1867646108606b0bc25e52c7
https://doi.org/10.21873/anticanres.13924

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Glyoxalase 1 and protein kinase Cλ as potential therapeutic targets for late‑stage breast cancer

Publikováno v: Oncology Letters

Cancer cells upregulate the expression levels of glycolytic enzymes in order to reach the increased glycolysis required. One such upregulated glycolytic enzyme is glyoxalase 1 (GLO 1), which catalyzes the conversion of toxic methylglyoxal to nontoxic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d62032d7341f241ba39477b0c490ad9
https://doi.org/10.3892/ol.2021.12808

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