Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Hitomi, Jo"'
Autor:
Hitomi Jo, MD, PhD, Tatsuya Yoshida, MD, PhD, Shigehiro Yagishita, MD, PhD, Mayu Ohuchi, PhD, Yuji Matsumoto, MD, PhD, Yuki Shinno, MD, PhD, Yusuke Okuma, MD, PhD, Yasushi Goto, MD, PhD, Hidehito Horinouchi, MD, PhD, Noboru Yamamoto, MD, PhD, Kazuhisa Takahashi, MD, PhD, Noriko Motoi, MD, PhD, Akinobu Hamada, PhD, Yuichiro Ohe, MD, PhD
Publikováno v:
JTO Clinical and Research Reports, Vol 4, Iss 4, Pp 100474- (2023)
Introduction: Immune checkpoint inhibitors (ICIs) induce long-term, durable responses in patients with advanced NSCLC. Nevertheless, these responses are limited to a few patients, and most responders have disease progression. The purpose of this stud
Externí odkaz:
https://doaj.org/article/fbc7fcbfc26745ea85440370d0442d63
Autor:
Mayu, Ohuchi, Shigehiro, Yagishita, Hitomi, Jo, Kazumasa, Akagi, Ryoko, Inaba Higashiyama, Ken, Masuda, Yuki, Shinno, Yusuke, Okuma, Tatsuya, Yoshida, Yasushi, Goto, Hidehito, Horinouchi, Yoshinori, Makino, Noboru, Yamamoto, Yuichiro, Ohe, Akinobu, Hamada
Publikováno v:
Lung Cancer. 173:35-42
The dosing pattern of pembrolizumab is based on population pharmacokinetic (Pop-PK) analysis of clinical trials. Data for Japanese patients or patient populations with poor conditions such as cachexia are scarce. In this study, we performed a Pop-PK
Autor:
Akinobu Hamada, Kazuhisa Takahashi, Hiroyuki Mano, Yasushi Yatabe, Noriko Motoi, Shun-ichi Watanabe, Yuichiro Ohe, Hidehito Horinouchi, Yuji Matsumoto, Toshihide Ueno, Shinji Kohsaka, Mikiko Suzuki, Shoraku Ryu, Yoshiharu Hayashi, Shigehiro Yagishita, Hitomi Jo
Supplementary Figure 2Figure 2A shows HER2 immunostaining images of each passage of LC-005. The RNA expression levels of EGFR, ERBB2, ERBB3 and MET in each PDX are shown in Figure 2B.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92b339c0a6969eb0d5d31fd4de003777
https://doi.org/10.1158/1535-7163.22521918.v1
https://doi.org/10.1158/1535-7163.22521918.v1
Autor:
Akinobu Hamada, Kazuhisa Takahashi, Hiroyuki Mano, Yasushi Yatabe, Noriko Motoi, Shun-ichi Watanabe, Yuichiro Ohe, Hidehito Horinouchi, Yuji Matsumoto, Toshihide Ueno, Shinji Kohsaka, Mikiko Suzuki, Shoraku Ryu, Yoshiharu Hayashi, Shigehiro Yagishita, Hitomi Jo
Supplementary Table 1(A) MRM transitions of each compound(B) LC condition(C) MS/MS Parameters were optimized for each compound(D) MALDI-MS analytical conditions of the testing drugs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4faac4b38bbc63bb83dad63540f5342e
https://doi.org/10.1158/1535-7163.22521915
https://doi.org/10.1158/1535-7163.22521915
Autor:
Akinobu Hamada, Kazuhisa Takahashi, Hiroyuki Mano, Yasushi Yatabe, Noriko Motoi, Shun-ichi Watanabe, Yuichiro Ohe, Hidehito Horinouchi, Yuji Matsumoto, Toshihide Ueno, Shinji Kohsaka, Mikiko Suzuki, Shoraku Ryu, Yoshiharu Hayashi, Shigehiro Yagishita, Hitomi Jo
Supplementary Table 3(A) Establishment status by histological subtype(B) Establishment status by gene aberration.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b00a2cf63203fab46823ca465e404b0
https://doi.org/10.1158/1535-7163.22521909
https://doi.org/10.1158/1535-7163.22521909
Autor:
Akinobu Hamada, Kazuhisa Takahashi, Hiroyuki Mano, Yasushi Yatabe, Noriko Motoi, Shun-ichi Watanabe, Yuichiro Ohe, Hidehito Horinouchi, Yuji Matsumoto, Toshihide Ueno, Shinji Kohsaka, Mikiko Suzuki, Shoraku Ryu, Yoshiharu Hayashi, Shigehiro Yagishita, Hitomi Jo
Patient-derived xenografts (PDX) can adequately reflect clinical drug efficacy. However, the methods for evaluating drug efficacy are not fully established. We selected five non–small cell lung cancer (NSCLC) PDXs with genetic alterations from esta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d539522f2f062e29712520ccb82d869
https://doi.org/10.1158/1535-7163.c.6543219.v1
https://doi.org/10.1158/1535-7163.c.6543219.v1
Autor:
Akinobu Hamada, Kazuhisa Takahashi, Hiroyuki Mano, Yasushi Yatabe, Noriko Motoi, Shun-ichi Watanabe, Yuichiro Ohe, Hidehito Horinouchi, Yuji Matsumoto, Toshihide Ueno, Shinji Kohsaka, Mikiko Suzuki, Shoraku Ryu, Yoshiharu Hayashi, Shigehiro Yagishita, Hitomi Jo
Supplementary Table 2Chromatograms of the testing drugs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e311f1bf27de1f29874e2b3d45e355c
https://doi.org/10.1158/1535-7163.22521912
https://doi.org/10.1158/1535-7163.22521912
Autor:
Akinobu Hamada, Kazuhisa Takahashi, Hiroyuki Mano, Yasushi Yatabe, Noriko Motoi, Shun-ichi Watanabe, Yuichiro Ohe, Hidehito Horinouchi, Yuji Matsumoto, Toshihide Ueno, Shinji Kohsaka, Mikiko Suzuki, Shoraku Ryu, Yoshiharu Hayashi, Shigehiro Yagishita, Hitomi Jo
Supplementary Table 6Region of interest analysis - detail
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e1a307c834a204732ba1fe8b421de4
https://doi.org/10.1158/1535-7163.22521900.v1
https://doi.org/10.1158/1535-7163.22521900.v1
Autor:
Akinobu Hamada, Kazuhisa Takahashi, Hiroyuki Mano, Yasushi Yatabe, Noriko Motoi, Shun-ichi Watanabe, Yuichiro Ohe, Hidehito Horinouchi, Yuji Matsumoto, Toshihide Ueno, Shinji Kohsaka, Mikiko Suzuki, Shoraku Ryu, Yoshiharu Hayashi, Shigehiro Yagishita, Hitomi Jo
Supplementary Table 4Whole-exome sequencing result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::753b95b5d02f4aad9500177414df3c06
https://doi.org/10.1158/1535-7163.22521906
https://doi.org/10.1158/1535-7163.22521906
Autor:
Akinobu Hamada, Kazuhisa Takahashi, Hiroyuki Mano, Yasushi Yatabe, Noriko Motoi, Shun-ichi Watanabe, Yuichiro Ohe, Hidehito Horinouchi, Yuji Matsumoto, Toshihide Ueno, Shinji Kohsaka, Mikiko Suzuki, Shoraku Ryu, Yoshiharu Hayashi, Shigehiro Yagishita, Hitomi Jo
Supplementary Figure 1The spectra and annotations of fragment ions from pure test drugs of afatinib, gefitinib, osimertinib, poziotinib, brigatinib, crizotinib, entrectinib, and lorlatinib are shown.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db1ee3d939729a080f9e91fab0a45042
https://doi.org/10.1158/1535-7163.22521921
https://doi.org/10.1158/1535-7163.22521921