Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Hiten D. Madhani"'
Autor:
Jordan E. Burke, Adam D. Longhurst, Prashanthi Natarajan, Beiduo Rao, John Liu, Jade Sales-Lee, Yasaman Mortensen, James J. Moresco, Jolene K. Diedrich, John R. Yates, Hiten D. Madhani
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 7, Pp 2235-2244 (2019)
The human pathogenic yeast Cryptococcus neoformans silences transposable elements using endo-siRNAs and an Argonaute, Ago1. Endo-siRNAs production requires the RNA-dependent RNA polymerase, Rdp1, and two partially redundant Dicer enzymes, Dcr1 and Dc
Externí odkaz:
https://doaj.org/article/7f7f371b930043a1aae902382619436c
Autor:
David Mavor, Kyle A. Barlow, Daniel Asarnow, Yuliya Birman, Derek Britain, Weilin Chen, Evan M. Green, Lillian R. Kenner, Bruk Mensa, Leanna S. Morinishi, Charlotte A. Nelson, Erin M. Poss, Pooja Suresh, Ruilin Tian, Taylor Arhar, Beatrice E. Ary, David P. Bauer, Ian D. Bergman, Rachel M. Brunetti, Cynthia M. Chio, Shizhong A. Dai, Miles S. Dickinson, Susanna K. Elledge, Cole V. M. Helsell, Nathan L. Hendel, Emily Kang, Nadja Kern, Matvei S. Khoroshkin, Lisa L. Kirkemo, Greyson R. Lewis, Kevin Lou, Wesley M. Marin, Alison M. Maxwell, Peter F. McTigue, Douglas Myers-Turnbull, Tamas L. Nagy, Andrew M. Natale, Keely Oltion, Sergei Pourmal, Gabriel K. Reder, Nicholas J. Rettko, Peter J. Rohweder, Daniel M. C Schwarz, Sophia K. Tan, Paul V. Thomas, Ryan W. Tibble, Jason P. Town, Mary K. Tsai, Fatima S. Ugur, Douglas R. Wassarman, Alexander M. Wolff, Taia S. Wu, Derek Bogdanoff, Jennifer Li, Kurt S. Thorn, Shane O'Conchúir, Danielle L. Swaney, Eric D. Chow, Hiten D. Madhani, Sy Redding, Daniel N. Bolon, Tanja Kortemme, Joseph L. DeRisi, Martin Kampmann, James S. Fraser
Publikováno v:
Biology Open, Vol 7, Iss 7 (2018)
Although the primary protein sequence of ubiquitin (Ub) is extremely stable over evolutionary time, it is highly tolerant to mutation during selection experiments performed in the laboratory. We have proposed that this discrepancy results from the di
Externí odkaz:
https://doaj.org/article/120375a9425d4b15800ba82e59af4543
Autor:
Arielle Butts, Kristy Koselny, Yeissa Chabrier-Roselló, Camile P. Semighini, Jessica C. S. Brown, Xuying Wang, Sivakumar Annadurai, Louis DiDone, Julie Tabroff, Wayne E. Childers, Magid Abou-Gharbia, Melanie Wellington, Maria E. Cardenas, Hiten D. Madhani, Joseph Heitman, Damian J. Krysan
Publikováno v:
mBio, Vol 5, Iss 1 (2014)
ABSTRACT Cryptococcosis is an infectious disease of global significance for which new therapies are needed. Repurposing previously developed drugs for new indications can expedite the translation of new therapies from bench to beside. Here, we charac
Externí odkaz:
https://doaj.org/article/a47f62ddda0341948a47a260086195b2
Publikováno v:
PLoS Pathogens, Vol 5, Iss 6 (2009)
Externí odkaz:
https://doaj.org/article/2b61487cbc0942ac93454957dff8cbec
Autor:
David A. Brow, Hiten D. Madhani
Publikováno v:
Cell. 185:3639-3642
Publikováno v:
Nature. 608:161-167
Autor:
Sujin Lee, Stephen Abini-Agbomson, Daniela S. Perry, Allen Goodman, Beiduo Rao, Manning Y. Huang, Jolene K. Diedrich, James J. Moresco, John R. Yates, Karim-Jean Armache, Hiten D. Madhani
Publikováno v:
Nature Structural & Molecular Biology.
Targeted high throughput mutagenesis of the human spliceosome reveals itsin vivooperating principles
Autor:
Irene Beusch, Beiduo Rao, Michael Studer, Tetiana Luhovska, Viktorija Šukytė, Susan Lei, Juan Oses-Prieto, Em SeGraves, Alma Burlingame, Stefanie Jonas, Hiten D. Madhani
SUMMARYThe spliceosome is a staggeringly complex machine comprising, in humans, 5 snRNAs and >150 proteins. We scaled haploid CRISPR-Cas9 base editing to target the entire human spliceosome and interrogated the mutants using the U2 snRNP/SF3b inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8b20b5802d9a3a49a44e4fd6e113c4e
https://doi.org/10.1101/2022.11.13.516350
https://doi.org/10.1101/2022.11.13.516350
Autor:
Manning Y, Huang, Hiten D, Madhani
Publikováno v:
Nature microbiology. 7(8)
Autor:
Marcin Drąg, Jiří Brynda, Robin Kryštůfek, Jan Konvalinka, Eva Tloušt’ová, Martin Hradilek, Michael J. Boucher, Pavel Šácha, Justyna Grzymska, Pavlína Řezáčová, Miroslav Hájek, Jana Starková, Wioletta Rut, Charles S. Craik, Hiten D. Madhani, Pavel Majer
Publikováno v:
Journal of medicinal chemistry, vol 64, iss 10
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry
Cryptococcosis is an invasive infection that accounts for 15% of AIDS-related fatalities. Still, treating cryptococcosis remains a significant challenge due to the poor availability of effective antifungal therapies and emergence of drug resistance.