Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Hiten D Madhani"'
Publikováno v:
PLoS Genetics, Vol 16, Iss 9, p e1008744 (2020)
Qsp1 is a secreted quorum sensing peptide required for virulence of the fungal meningitis pathogen Cryptococcus neoformans. Qsp1 functions to control cell wall integrity in vegetatively growing cells and also functions in mating. Rather than acting o
Externí odkaz:
https://doaj.org/article/8c48846d48bb40a08b6d6218707120ae
Autor:
Cedric A Brimacombe, Jordan E Burke, Jahan-Yar Parsa, Sandra Catania, Teresa R O'Meara, Jessica N Witchley, Laura S Burrack, Hiten D Madhani, Suzanne M Noble
Publikováno v:
PLoS Biology, Vol 17, Iss 6, p e3000331 (2019)
Eukaryotes have evolved elaborate mechanisms to ensure that chromosomes segregate with high fidelity during mitosis and meiosis, and yet specific aneuploidies can be adaptive during environmental stress. Here, we identify a chromatin-based system req
Externí odkaz:
https://doaj.org/article/bf4b51dfd9104c519b547c34c1aeb20a
Autor:
Starlynn C Clarke, Phillip A Dumesic, Christina M Homer, Anthony J O'Donoghue, Florencia La Greca, Lenka Pallova, Pavel Majer, Hiten D Madhani, Charles S Craik
Publikováno v:
PLoS Pathogens, Vol 12, Iss 12, p e1006051 (2016)
The opportunistic fungal pathogen Cryptococcus neoformans is a major cause of mortality in immunocompromised individuals, resulting in more than 600,000 deaths per year. Many human fungal pathogens secrete peptidases that influence virulence, but in
Externí odkaz:
https://doaj.org/article/f632f8bdbdf246f2a8c203655a10e817
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0159292 (2016)
Schizosaccharomyces pombe is an outstanding model organism for cell biological investigations, yet the range of useful and well-characterized fluorescent proteins (XFPs) is limited. We generated and characterized three recoded fluorescent proteins fo
Externí odkaz:
https://doaj.org/article/f7c7b1c9c43943d49d069e9a1e04749e
Autor:
Jessica C S Brown, Hiten D Madhani
Publikováno v:
PLoS Genetics, Vol 8, Iss 12, p e1003168 (2012)
In many human fungal pathogens, genes required for disease remain largely unannotated, limiting the impact of virulence gene discovery efforts. We tested the utility of a cross-species genetic interaction profiling approach to obtain clues to the mol
Externí odkaz:
https://doaj.org/article/7152166082754abdb419659a3f6fed18
Autor:
Hiten D Madhani
Publikováno v:
PLoS Pathogens, Vol 7, Iss 10, p e1002301 (2011)
Externí odkaz:
https://doaj.org/article/581849599d144a1c824c8dc7a871fa29
Autor:
Cheryl D Chun, Hiten D Madhani
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12489 (2010)
Cryptococcus neoformans is a human opportunistic fungal pathogen responsible for approximately 1/3 of HIV/AIDS deaths worldwide. This budding yeast expresses a polysaccharide capsule necessary for virulence. Capsule production inhibits phagocytosis b
Externí odkaz:
https://doaj.org/article/d3066a33b400479dbad0a2c2a32547c7
Autor:
William W Hwang, Hiten D Madhani
Publikováno v:
PLoS Genetics, Vol 5, Iss 8, p e1000588 (2009)
In Saccharomyces cerevisiae, the conserved phosphatase Cdc14 is required for the exit from mitosis. It is anchored on nucleolar chromatin by the Cfi1/Net1 protein until early anaphase, at which time it is released into the nucleoplasm. Two poorly und
Externí odkaz:
https://doaj.org/article/4e9a01f19d714525a52950367a90dac1
Publikováno v:
PLoS Pathogens, Vol 3, Iss 2, p e22 (2007)
Fungal pathogens of humans require molecular oxygen for several essential biochemical reactions, yet virtually nothing is known about how they adapt to the relatively hypoxic environment of infected tissues. We isolated mutants defective in growth un
Externí odkaz:
https://doaj.org/article/32fe9e808a594619b68a8968cb1fd77a
Autor:
Michael S Kobor, Shivkumar Venkatasubrahmanyam, Marc D Meneghini, Jennifer W Gin, Jennifer L Jennings, Andrew J Link, Hiten D Madhani, Jasper Rine
Publikováno v:
PLoS Biology, Vol 2, Iss 5, p E131 (2004)
The conserved histone variant H2A.Z functions in euchromatin to antagonize the spread of heterochromatin. The mechanism by which histone H2A is replaced by H2A.Z in the nucleosome is unknown. We identified a complex containing 13 different polypeptid
Externí odkaz:
https://doaj.org/article/7161aceb167d49fa992ba18d946d7992