Zobrazeno 1 - 10
of 359
pro vyhledávání: '"Hiten D Madhani"'
Autor:
Konopka, James B
Publikováno v:
The Quarterly Review of Biology, 2007 Jun . 82(2), 150-150.
Externí odkaz:
https://www.jstor.org/stable/10.1086/519590
Autor:
Jordan E. Burke, Adam D. Longhurst, Prashanthi Natarajan, Beiduo Rao, John Liu, Jade Sales-Lee, Yasaman Mortensen, James J. Moresco, Jolene K. Diedrich, John R. Yates, Hiten D. Madhani
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 7, Pp 2235-2244 (2019)
The human pathogenic yeast Cryptococcus neoformans silences transposable elements using endo-siRNAs and an Argonaute, Ago1. Endo-siRNAs production requires the RNA-dependent RNA polymerase, Rdp1, and two partially redundant Dicer enzymes, Dcr1 and Dc
Externí odkaz:
https://doaj.org/article/7f7f371b930043a1aae902382619436c
Autor:
James Konopka
Publikováno v:
The Quarterly Review of Biology. 82:150-150
Publikováno v:
PLoS Genetics, Vol 16, Iss 9, p e1008744 (2020)
Qsp1 is a secreted quorum sensing peptide required for virulence of the fungal meningitis pathogen Cryptococcus neoformans. Qsp1 functions to control cell wall integrity in vegetatively growing cells and also functions in mating. Rather than acting o
Externí odkaz:
https://doaj.org/article/8c48846d48bb40a08b6d6218707120ae
Autor:
David A. Brow, Hiten D. Madhani
Publikováno v:
Cell. 185:3639-3642
Autor:
Sujin Lee, Stephen Abini-Agbomson, Daniela S. Perry, Allen Goodman, Beiduo Rao, Manning Y. Huang, Jolene K. Diedrich, James J. Moresco, John R. Yates, Karim-Jean Armache, Hiten D. Madhani
Publikováno v:
Nature Structural & Molecular Biology.
Publikováno v:
Nature. 608:161-167
Autor:
Cedric A Brimacombe, Jordan E Burke, Jahan-Yar Parsa, Sandra Catania, Teresa R O'Meara, Jessica N Witchley, Laura S Burrack, Hiten D Madhani, Suzanne M Noble
Publikováno v:
PLoS Biology, Vol 17, Iss 6, p e3000331 (2019)
Eukaryotes have evolved elaborate mechanisms to ensure that chromosomes segregate with high fidelity during mitosis and meiosis, and yet specific aneuploidies can be adaptive during environmental stress. Here, we identify a chromatin-based system req
Externí odkaz:
https://doaj.org/article/bf4b51dfd9104c519b547c34c1aeb20a
Targeted high throughput mutagenesis of the human spliceosome reveals itsin vivooperating principles
Autor:
Irene Beusch, Beiduo Rao, Michael Studer, Tetiana Luhovska, Viktorija Šukytė, Susan Lei, Juan Oses-Prieto, Em SeGraves, Alma Burlingame, Stefanie Jonas, Hiten D. Madhani
SUMMARYThe spliceosome is a staggeringly complex machine comprising, in humans, 5 snRNAs and >150 proteins. We scaled haploid CRISPR-Cas9 base editing to target the entire human spliceosome and interrogated the mutants using the U2 snRNP/SF3b inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8b20b5802d9a3a49a44e4fd6e113c4e
https://doi.org/10.1101/2022.11.13.516350
https://doi.org/10.1101/2022.11.13.516350
Autor:
David Mavor, Kyle A. Barlow, Daniel Asarnow, Yuliya Birman, Derek Britain, Weilin Chen, Evan M. Green, Lillian R. Kenner, Bruk Mensa, Leanna S. Morinishi, Charlotte A. Nelson, Erin M. Poss, Pooja Suresh, Ruilin Tian, Taylor Arhar, Beatrice E. Ary, David P. Bauer, Ian D. Bergman, Rachel M. Brunetti, Cynthia M. Chio, Shizhong A. Dai, Miles S. Dickinson, Susanna K. Elledge, Cole V. M. Helsell, Nathan L. Hendel, Emily Kang, Nadja Kern, Matvei S. Khoroshkin, Lisa L. Kirkemo, Greyson R. Lewis, Kevin Lou, Wesley M. Marin, Alison M. Maxwell, Peter F. McTigue, Douglas Myers-Turnbull, Tamas L. Nagy, Andrew M. Natale, Keely Oltion, Sergei Pourmal, Gabriel K. Reder, Nicholas J. Rettko, Peter J. Rohweder, Daniel M. C Schwarz, Sophia K. Tan, Paul V. Thomas, Ryan W. Tibble, Jason P. Town, Mary K. Tsai, Fatima S. Ugur, Douglas R. Wassarman, Alexander M. Wolff, Taia S. Wu, Derek Bogdanoff, Jennifer Li, Kurt S. Thorn, Shane O'Conchúir, Danielle L. Swaney, Eric D. Chow, Hiten D. Madhani, Sy Redding, Daniel N. Bolon, Tanja Kortemme, Joseph L. DeRisi, Martin Kampmann, James S. Fraser
Publikováno v:
Biology Open, Vol 7, Iss 7 (2018)
Although the primary protein sequence of ubiquitin (Ub) is extremely stable over evolutionary time, it is highly tolerant to mutation during selection experiments performed in the laboratory. We have proposed that this discrepancy results from the di
Externí odkaz:
https://doaj.org/article/120375a9425d4b15800ba82e59af4543