Results and insights from a phase I clinical trial of Lomecel-B for Alzheimer's disease

Autor: Brody, Mark, Agronin, Marc, Herskowitz, Brad J, Bookheimer, Susan Y, Small, Gary W, Hitchinson, Benjamin, Ramdas, Kevin, Wishard, Tyler, McInerney, Katalina Fernández, Vellas, Bruno, Sierra, Felipe, Jiang, Zhijie, Mcclain-Moss, Lisa, Perez, Carmen, Fuquay, Ana, Rodriguez, Savannah, Hare, Joshua M, Oliva, Anthony A, Baumel, Bernard

Publikováno v: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 19, iss 1

HypothesisWe hypothesized that Lomecel-B, an allogeneic medicinal signaling cell (MSC) therapeutic candidate for Alzheimer's disease (AD), is safe and potentially disease-modifying via pleiotropic mechanisms of action.Key predictionsWe prospectively

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::ff8ea52de21e595a4477584e3847bb79
https://escholarship.org/uc/item/4mq6x362

Results and insights from a phase I clinical trial of Lomecel-B for Alzheimer's disease.

Autor: Brody M; Brain Matters Research, Delray Beach, Florida, USA., Agronin M; Miami Jewish Health, Miami, Florida, USA., Herskowitz BJ; The Neurology Group, Kendall, Florida, USA., Bookheimer SY; Dept. of Psychiatry and Biobehavioral Sciences, and Semel Institute For Neuroscience and Human Behavior, UCLA David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA., Small GW; Psychiatry, Hackensack Meridian Health, Hackensack University Medical Center, Hackensack, New Jersey, USA., Hitchinson B; Longeveron Inc., Miami, Florida, USA., Ramdas K; Longeveron Inc., Miami, Florida, USA., Wishard T; Interdepartmental Program in Neuroscience, UCLA, and Semel Institute For Neuroscience and Human Behavior, UCLA David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA., McInerney KF; Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA., Vellas B; Gérontopôle, Department of Geriatric Internal Medicine, University of Toulouse, Toulouse, France., Sierra F; National Institute of Aging, National Institutes of Health, Bethesda, Maryland, USA., Jiang Z; M2Gen, Tampa, Florida, USA., Mcclain-Moss L; Longeveron Inc., Miami, Florida, USA., Perez C; Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA., Fuquay A; Brain Matters Research, Delray Beach, Florida, USA., Rodriguez S; The Neurology Group, Kendall, Florida, USA., Hare JM; Longeveron Inc., Miami, Florida, USA.; Department of Medicine and Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, Florida, USA., Oliva AA Jr; Longeveron Inc., Miami, Florida, USA., Baumel B; Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA.

Publikováno v: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2023 Jan; Vol. 19 (1), pp. 261-273. Date of Electronic Publication: 2022 Mar 31.