Cooling of Cells and Organs Confers Extensive DNA Strand Breaks Through Oxidative Stress and ATP Depletion

Autor: Marziyeh Tolouee, Koen D. W. Hendriks, Fia Fia Lie, Lucas P. Gartzke, Maaike Goris, Femke Hoogstra-Berends, Steven Bergink, Robert H. Henning

Publikováno v: Cell Transplantation, 31. SAGE Publishing
Cell Transplantation, 31, 1-12. SAGE Publishing
Cell Transplantation, 31:09636897221108705. SAGE Publishing

Cooling at 4°C is routinely used to lower metabolism and preserve cell and tissue integrity in laboratory and clinical settings, including organ transplantation. However, cooling and rewarming produce cell damage, attributed primarily to a burst of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3de5dfbe6c757cea76b568220921a75d
https://doi.org/10.1177/09636897221108705

DOT1L regulates lipid biosynthesis and inflammatory responses in macrophages and promotes atherosclerotic plaque stability

Autor: Lisa Willemsen, Koen H.M. Prange, Annette E. Neele, Cindy P.A.A. van Roomen, Marion Gijbels, Guillermo R. Griffith, Myrthe den Toom, Linda Beckers, Ricky Siebeler, Nathanael J. Spann, Hung-Jen Chen, Laura A. Bosmans, Andrej Gorbatenko, Suzanne van Wouw, Noam Zelcer, Heinz Jacobs, Fred van Leeuwen, Menno P.J. de Winther

Publikováno v: Cell Reports, 41(8):111703. Cell Press
Cell reports, 41(8):111703. Cell Press

Macrophages are critical immune cells in inflammatory diseases, and their differentiation and function are tightly regulated by histone modifications. H3K79 methylation is a histone modification associated with active gene expression, and DOT1L is th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c05bb3dde3236461fb0442e54d9df7cd
https://cris.maastrichtuniversity.nl/en/publications/8e61cfc8-7c5e-4e6b-ab6b-cb1ba514a359

NETosis and Nucleosome Biomarkers in Septic Shock and Critical COVID-19 Patients:An Observational Study

Autor: Laure Morimont, Mélanie Dechamps, Clara David, Céline Bouvy, Constant Gillot, Hélène Haguet, Julien Favresse, Lorian Ronvaux, Julie Candiracci, Marielle Herzog, Pierre-François Laterre, Julien De Poortere, Sandrine Horman, Christophe Beauloye, Jonathan Douxfils

Publikováno v: Morimont, L, Dechamps, M, David, C, Bouvy, C, Gillot, C, Haguet, H, Favresse, J, Ronvaux, L, Candiracci, J, Herzog, M, Laterre, P-F, De Poortere, J, Horman, S, Beauloye, C & Douxfils, J 2022, ' NETosis and Nucleosome Biomarkers in Septic Shock and Critical COVID-19 Patients : An Observational Study ', Biomolecules, vol. 12, no. 8, 1038 . https://doi.org/10.3390/biom12081038
Biomolecules, Vol. 12, no.8, p. 1038 (2022)
Biomolecules, Vol. 12, no. 8, p. 1038 (2022)
Biomolecules; Volume 12; Issue 8; Pages: 1038

Background: Neutrophil extracellular traps’ (NETs’) formation is a mechanism of defense that neutrophils deploy as an alternative to phagocytosis, to constrain the spread of microorganisms. Aim: The aim was to evaluate biomarkers of NETs’ forma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6c620e02ac83f3f9f8b808370f8cab9
https://pure.unamur.be/ws/files/66869429/11924_2022_Morimont.pdf

Histone H3K27 demethylase UTX compromises articular chondrocyte anabolism and aggravates osteoarthritic degeneration

Autor: Wei-Shiung Lian, Re-Wen Wu, Jih-Yang Ko, Yu-Shan Chen, Shao-Yu Wang, Chun-Ping Yu, Holger Jahr, Feng-Sheng Wang

Publikováno v: Cell death & disease 13, 538 (2022). doi:10.1038/s41419-022-04985-5
Cell Death & Disease, 13(6):538. Nature Publishing Group

Cell death & disease 13, 538 (2022). doi:10.1038/s41419-022-04985-5
Published by Nature Publishing Group, London [u.a.]

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bac468804961e5daaa1322fe4de68f7f
https://doi.org/10.1038/s41419-022-04985-5

Recurrent de novo missense variants across multiple histone H4 genes underlie a neurodevelopmental syndrome

Autor: Tessadori, Federico, Duran, Karen, Knapp, Karen, Fellner, Matthias, Deciphering Developmental Disorders Study, Smithson, Sarah, Beleza Meireles, Ana, Elting, Mariet W, Waisfisz, Quinten, O'Donnell-Luria, Anne, Nowak, Catherine, Douglas, Jessica, Ronan, Anne, Brunet, Theresa, Kotzaeridou, Urania, Svihovec, Shayna, Saenz, Margarita S, Thiffault, Isabelle, Del Viso, Florencia, Devine, Patrick, Rego, Shannon, Tenney, Jessica, van Haeringen, Arie, Ruivenkamp, Claudia A L, Koene, Saskia, Robertson, Stephen P, Deshpande, Charulata, Pfundt, Rolph, Verbeek, Nienke, van de Kamp, Jiddeke M, Weiss, Janneke M M, Ruiz, Anna, Gabau, Elisabeth, Banne, Ehud, Pepler, Alexander, Bottani, Armand, Laurent, Sacha, Guipponi, Michel, Bijlsma, Emilia, Bruel, Ange-Line, Sorlin, Arthur, Willis, Mary, Powis, Zoe, Smol, Thomas, Vincent-Delorme, Catherine, Baralle, Diana, Colin, Estelle, Revencu, Nicole, Calpena, Eduardo, Wilkie, Andrew O M, Chopra, Maya, Cormier-Daire, Valerie, Keren, Boris, Afenjar, Alexandra, Niceta, Marcello, Terracciano, Alessandra, Specchio, Nicola, Tartaglia, Marco, Rio, Marlene, Barcia, Giulia, Rondeau, Sophie, Colson, Cindy, Bakkers, Jeroen, Mace, Peter D, Bicknell, Louise S, van Haaften, Gijs

Publikováno v: American journal of human genetics, Vol. 109, no.4, p. 750-758 (2022)
American journal of human genetics, 109(4), 750-758. Cell Press
American Journal of Human Genetics, 109, 750-758
American Journal of Human Genetics, 109(4), 750-758. CELL PRESS
Deciphering Developmental Disorders Study 2022, ' Recurrent de novo missense variants across multiple histone H4 genes underlie a neurodevelopmental syndrome ', American journal of human genetics, vol. 109, no. 4, pp. 750-758 . https://doi.org/10.1016/j.ajhg.2022.02.003
American Journal of Human Genetics, 109(4), 750-758. Cell Press
American Journal of Human Genetics, 109, 4, pp. 750-758

Contains fulltext : 252023.pdf (Publisher’s version ) (Open Access) Chromatin is essentially an array of nucleosomes, each of which consists of the DNA double-stranded fiber wrapped around a histone octamer. This organization supports cellular proc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d26baf96963f72d8c775857dfc818214
https://doi.org/10.1016/j.ajhg.2022.02.003