Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Histone deacetylases inhibitors"'
Publikováno v:
Results in Chemistry, Vol 7, Iss , Pp 101253- (2024)
In the past two decades, targeted cancer therapy has emerged as a novel class of anticancer therapeutics, besides traditional chemotherapy, surgery, and radiotherapy. Inhibition of HDACs represents a promising avenue for cancer therapeutics and initi
Externí odkaz:
https://doaj.org/article/622510a4577341a5a0d69e5d36bcc1e9
Autor:
Marina Baretti, Adrian G. Murphy, Marianna Zahurak, Nicole Gianino, Rose Parkinson, Rosalind Walker, Tamara Y. Lopez-Vidal, Lei Zheng, Gary Rosner, Nita Ahuja, Schalper Kurt, Nilofer S. Azad
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-16 (2023)
Abstract Background Approximately 95% of advanced colorectal cancer patients (CRC) have mismatch repair MMR-proficient (MMRp) tumors, which do not respond to PD1 blockade alone. Preclinical studies have shown that combined histone deacetylases (HDAC)
Externí odkaz:
https://doaj.org/article/54d8bce8d548488f940ee627fd83b2ce
Autor:
Fatmah A. Bakhdar, MSc, Hala S. Abdel kawy, PhD, Rania M. Magadmi, PhD, Eman A. El-Kordy, PhD, Abdulhakeem S. Alamri, PhD
Publikováno v:
Journal of Taibah University Medical Sciences, Vol 18, Iss 1, Pp 9-18 (2023)
الملخص: أهداف البحث: يعتبر مثبط المناعة (التاكروليموس) أهم مسبب للإصابة بنوع السكري الجديد ما بعد زراعة الكلى. تهدف الدراسة لتقييم فعالية
Externí odkaz:
https://doaj.org/article/5181aa960145458c84a4c4eb9abab3cf
Publikováno v:
Pharmaceuticals, Vol 16, Iss 2, p 227 (2023)
Despite recent advances in multimodality therapy for glioblastoma (GB) incorporating surgery, radiotherapy, chemotherapy and targeted therapy, the overall prognosis remains poor. One of the interesting targets for GB therapy is the histone deacetylas
Externí odkaz:
https://doaj.org/article/87a2bebb71fb4d559895220cf6a325a7
Autor:
Schäker-Hübner, Linda, Haschemi, Reza, Büch, Thomas, Kraft, Fabian B., Brumme, Birke, Schöler, Andrea, Jenke, Robert, Meiler, Jens, Aigner, Achim, Bendas, Gerd, Hansen, Finn K.
Herein we report the structure-activity and structure-physicochemical property relationships of a series of class I selective ortho-aminoanilides targeting the “foot-pocket” in HDAC1&2. To balance the structural benefits and the physicochemical d
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A86856
https://ul.qucosa.de/api/qucosa%3A86856/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A86856/attachment/ATT-0/
Autor:
Rui Chen, Mengxian Zhang, Yangmei Zhou, Wenjing Guo, Ming Yi, Ziyan Zhang, Yanpeng Ding, Yali Wang
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-18 (2020)
Abstract The epigenetic abnormality is generally accepted as the key to cancer initiation. Epigenetics that ensure the somatic inheritance of differentiated state is defined as a crucial factor influencing malignant phenotype without altering genotyp
Externí odkaz:
https://doaj.org/article/7d138992bc154e408b6a362d8d34d5a2
Publikováno v:
Biomedicines, Vol 10, Iss 11, p 2799 (2022)
Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor in adults with a poor prognosis. Despite significant progress in drug development, the blood–brain barrier (BBB) continues to limit the use of novel chemotherapeutics. T
Externí odkaz:
https://doaj.org/article/52984fec04664b2380270c0d309d5d14
Akademický článek
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Akademický článek
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Autor:
Surabhi Shukla, Babu L. Tekwani
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Histone deacetylases (HADC) are the enzymes that remove acetyl group from lysine residue of histones and non-histone proteins and regulate the process of transcription by binding to transcription factors and regulating fundamental cellular process su
Externí odkaz:
https://doaj.org/article/6c29d753d1f3431c967f61728a29c7c5