Zobrazeno 1 - 10
of 12 068
pro vyhledávání: '"Histone deacetylase inhibitor"'
Publikováno v:
Cancer Management and Research, Vol Volume 16, Pp 855-869 (2024)
Markus Joerger,1 Kira-Lee Koster,1 Tomas Janik,2 Floris A de Jong3,4 1Department of Medical Oncology and Hematology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland; 2Research & Development Department, Mundipharma Research Limited, Cambridge, U
Externí odkaz:
https://doaj.org/article/c54fad9cb73b45debd211cdd21d2c10a
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-20 (2024)
Abstract Histone deacetylase (HDAC) serves as a critical molecular regulator in the pathobiology of various malignancies and have garnered attention as a viable target for therapeutic intervention. A variety of HDAC inhibitors (HDACis) have been deve
Externí odkaz:
https://doaj.org/article/d9a261daa6cb42d2b649425d48e72d24
Autor:
Stephen G. Smoots, Anna R. Schreiber, Marilyn M. Jackson, Stacey M. Bagby, Adrian T A. Dominguez, Evan D. Dus, Cameron A. Binns, Morgan MacBeth, Phaedra A. Whitty, Jennifer R. Diamond, Todd M. Pitts
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-13 (2024)
Abstract Background Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with a poor prognosis. Doxorubicin is part of standard curative therapy for TNBC, but chemotherapy resistance remains an important clinical challenge. Boc
Externí odkaz:
https://doaj.org/article/e983610b7e904575a33047cfca75f04a
Publikováno v:
Journal of Inflammation Research, Vol Volume 17, Pp 947-955 (2024)
Xue-Mei Liu,1,2,* Liu Yang,1,2,* Qi-Bin Yang1 1Department of Rheumatology and Immunology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province, 637000, People’s Republic of China; 2Department of Clinical Medicine
Externí odkaz:
https://doaj.org/article/acdc966286154bd1ba9be97d40276af1
Akademický článek
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Autor:
Kyra Parker, Yanfeng Zhang, Gavin Anchondo, Ashlyn Smith, Sergio Guerrero Pacheco, Tadashi Kondo, Le Su
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
The SS18-SSX fusion protein is an oncogenic driver in synovial sarcoma. At the molecular level, SS18-SSX functions as both an activator and a repressor to coordinate transcription of different genes responsible for tumorigenesis. Here, we identify th
Externí odkaz:
https://doaj.org/article/3649b9f35f3b4e67807c6c0cb07b8882
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Histone deacetylases (HDAC) catalyze the removal of acetylation modifications on histones and non-histone proteins, which regulates gene expression and other cellular processes. HDAC inhibitors (HDACi), approved anti-cancer agents, emerge as a potent
Externí odkaz:
https://doaj.org/article/449d7c1e967a438984bbbcc079b04ab2
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8455 (2024)
Anti-estrogenic therapy is established in the management of estrogen receptor (ER)-positive breast cancer. However, to overcome resistance and improve therapeutic outcome, novel strategies are needed such as targeting widely recognized aberrant epige
Externí odkaz:
https://doaj.org/article/ec7f0e1cf5d34145a8b07bdb605b1279
Autor:
Kaoutar Bentayebi, Keittisak Suwan, Azzedine Ibrahimi, Louati Sara, Mouna Ouadghiri, Tarik Aanniz, Saaïd Amzazi, Lahcen Belyamani, Amin Hajitou, Rachid Eljaoudi
Publikováno v:
Brain Disorders, Vol 13, Iss , Pp 100113- (2024)
Diffuse intrinsic pontine glioma (DIPG) also referred as paediatric high-grade glioma (pHGG) is a fast-growing and aggressive type of childhood brain cancer. Recent studies investigating the molecular pathogenesis of DIPG have identified new therapeu
Externí odkaz:
https://doaj.org/article/2354290142a34e50bd0c2e747106451a
Autor:
Joana Grand-Guillaume, Rosalba Mansi, Raghuvir H. Gaonkar, Sandra Zanger, Melpomeni Fani, Philippe J. Eugster, Maja Beck Popovic, Eric Grouzmann, Karim Abid
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-20 (2023)
Abstract Background Neuroblastoma (NB) and pheochromocytoma/paraganglioma (PHEO/PGL) are neuroendocrine tumors. Imaging of these neoplasms is performed by scintigraphy after injection of radiolabeled meta-iodobenzylguanidine (mIBG), a norepinephrine
Externí odkaz:
https://doaj.org/article/d02749981c7d40669065e704f066964b