Zobrazeno 1 - 10
of 354
pro vyhledávání: '"Histone deacetylase 4"'
Autor:
Qunyan Chen, Jiachang Lao
Publikováno v:
Journal of Physiological Investigation, Vol 67, Iss 4, Pp 174-186 (2024)
Sepsis is a syndrome of systemic inflammatory response resulting from infection, which can lead to severe lung injury. Histone deacetylase 4 (HDAC4) is a key protein known to regulate a wide range of cellular processes. This study was designed to inv
Externí odkaz:
https://doaj.org/article/fd2bcc3c82cf451da9b4f169cc47fa1a
Publikováno v:
BMC Musculoskeletal Disorders, Vol 25, Iss 1, Pp 1-12 (2024)
Abstract Background The present study evaluated whether the lack of histone deacetylase 4 (HDAC4) increases endoplasmic reticulum stress-induced chondrocyte apoptosis by releasing activating transcription factor 4 (ATF4) in human osteoarthritis (OA)
Externí odkaz:
https://doaj.org/article/006ece27b2194f569842e9a04ef11ead
Publikováno v:
Jichu yixue yu linchuang, Vol 44, Iss 1, Pp 31-36 (2024)
Objective To investigate the role of autophagy in contrast-induced acute kidney injury (CI-AKI) in rats and to explore its possible mechanism. Methods SD rats were randomly divided into control group, acute kidney injury model group (intravenous inje
Externí odkaz:
https://doaj.org/article/a9ae06dd9cdd45908dee4f42f9627b07
Autor:
Li Guo, Hua Guo, Yuanyu Zhang, Zhi Chen, Jian Sun, Gaige Wu, Yunfei Wang, Yang Zhang, Xiaochun Wei, Pengcui Li
Publikováno v:
Bone & Joint Research, Vol 12, Iss 7, Pp 433-446 (2023)
Aims: To explore the novel molecular mechanisms of histone deacetylase 4 (HDAC4) in chondrocytes via RNA sequencing (RNA-seq) analysis. Methods: Empty adenovirus (EP) and a HDAC4 overexpression adenovirus were transfected into cultured human chondroc
Externí odkaz:
https://doaj.org/article/c4ac13bff6184c008a47bea7f98f73b5
Akademický článek
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Autor:
Zhen-Mi Liu, Xi Wang, Chen-Xi Li, Xue-Yan Liu, Xiao-Jing Guo, Yang Li, You-Lian Chen, Hong-Xing Ye, Huai-Sheng Chen
Publikováno v:
Journal of Innate Immunity, Vol 14, Iss 4, Pp 366-379 (2022)
As a serious and elusive syndrome caused by infection, sepsis causes a high rate of mortality around the world. Our investigation aims at exploring the role and possible mechanism of specificity protein-1 (SP1) in the development of sepsis. A mouse m
Externí odkaz:
https://doaj.org/article/18be8bb9dae04418898ee2b7b09f0f53
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-13 (2022)
Abstract Background Histone deacetylases (HDACs) have been identified to be implicated in the carcinogenesis and cancer progression. The present study was performed to probe into the effect of HDAC4 on radioresistance of esophageal carcinoma (EC). Me
Externí odkaz:
https://doaj.org/article/5da775c101b644e281ea2343530ed507
Publikováno v:
BMC Musculoskeletal Disorders, Vol 23, Iss 1, Pp 1-10 (2022)
Abstract Background The aim of this study was to evaluate whether histone deacetylase 4 S246/467/632A mutant (m-HDAC4) has enhanced function at histone deacetylase 4 (HDAC4) to attenuate cartilage degeneration in a rat model of osteoarthritis (OA). M
Externí odkaz:
https://doaj.org/article/db6d9ea4441b4db8a3202aab7f83a1f2
Akademický článek
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Autor:
Fengchen Shen, Xiying Hou, Tingting Li, Jianjun Yu, Huizhen Chen, Na Liu, Andong Qiu, Shougang Zhuang
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Histone deacetylase 4 (HDAC4) has been shown to be involved in cell proliferation, differentiation, and migration and is associated with a variety of cancers. However, the role of HDAC4 in renal fibrogenesis and its mechanisms are unclear. We assesse
Externí odkaz:
https://doaj.org/article/e6b513c1255349a7b155d9cbc8206542