Zobrazeno 1 - 10
of 11 689
pro vyhledávání: '"Histone Methyltransferase"'
Publikováno v:
mSphere, Vol 9, Iss 11 (2024)
ABSTRACT The malaria parasite Plasmodium falciparum employs antigenic variation of the virulence factor P. falciparum erythrocyte membrane protein 1 (PfEMP1) to escape adaptive immune responses during blood infection. Antigenic variation of PfEMP1 oc
Externí odkaz:
https://doaj.org/article/0caf02a1ac834e9799f7244f9e4df126
Autor:
Jean-Pierre Musabyimana, Sherihan Musa, Janice Manti, Ute Distler, Stefan Tenzer, Che Julius Ngwa, Gabriele Pradel
Publikováno v:
mSphere, Vol 9, Iss 11 (2024)
ABSTRACT The lifecycle progression of the malaria parasite Plasmodium falciparum requires precise tuning of gene expression including histone methylation. The histone methyltransferase PfSET10 was previously described as an H3K4 methyltransferase inv
Externí odkaz:
https://doaj.org/article/944351f611974aaf80930259b0204567
Publikováno v:
Regenerative Therapy, Vol 26, Iss , Pp 775-782 (2024)
Understanding the precise mechanism of BMSC (bone marrow mesenchymal stem cell) osteogenesis is critical for metabolic bone diseases and bone reconstruction. The histone-lysine N-methyltransferase 2D (KMT2D) acts as an important methyltransferase rel
Externí odkaz:
https://doaj.org/article/9eb636875c48482ead6ca11bec1aae6a
Publikováno v:
Heliyon, Vol 10, Iss 19, Pp e38582- (2024)
Gastric cancer, a common and severe malignancy, is associated with unfavorable outcomes and limited therapeutic options. The exploration of the potential link between plasma histone-modifying enzymes and gastric cancer through Mendelian randomization
Externí odkaz:
https://doaj.org/article/4e5cc26709144ffe9e1087965d444d6b
Autor:
Macario Osorio-Concepción, Carlos Lax, Damaris Lorenzo-Gutiérrez, José Tomás Cánovas-Márquez, Ghizlane Tahiri, Eusebio Navarro, Ulrike Binder, Francisco Esteban Nicolás, Victoriano Garre
Publikováno v:
IMA Fungus, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Mucorales are basal fungi that opportunistically cause a potentially fatal infection known as mucormycosis (black fungus disease), which poses a significant threat to human health due to its high mortality rate and its recent association wit
Externí odkaz:
https://doaj.org/article/b9f413d3edd7414bab1b37a7c36dfcb4
Autor:
Liu, Wenbo a, 1, Wang, Zhiyuan a, 1, Yang, Zhiran a, Huo, Bingjie b, Song, Yanru c, Li, Yong a, Tan, Bibo a, ⁎
Publikováno v:
In Heliyon 15 October 2024 10(19)
Development and validation of a generic methyltransferase enzymatic assay based on an SAH riboswitch
Publikováno v:
SLAS Discovery, Vol 29, Iss 4, Pp 100161- (2024)
Methylation of proteins and nucleic acids plays a fundamental role in epigenetic regulation, and discovery of methyltransferase (MT) inhibitors is an area of intense activity. Because of the diversity of MTs and their products, assay methods that det
Externí odkaz:
https://doaj.org/article/b24641d39fdd403a8bd985ead3a395eb
Akademický článek
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Autor:
Belén Ocaña-Paredes, Sebastián Rivera-Orellana, David Ramírez-Sánchez, Juliana Montalvo-Guerrero, María Paula Freire, Samantha Espinoza-Ferrao, Adriana Altamirano-Colina, Paulina Echeverría-Espinoza, María José Ramos-Medina, Gabriela Echeverría-Garcés, Danilo Granda-Moncayo, Andrea Jácome-Alvarado, María Gabriela Andrade, Andrés López-Cortés
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Epigenetic modifications, characterized by changes in gene expression without altering the DNA sequence, play a crucial role in the development and progression of cancer by significantly influencing gene activity and cellular function. This insight h
Externí odkaz:
https://doaj.org/article/6aeb0f23da1d4129ad4c7d906668331a
Publikováno v:
Cell Insight, Vol 3, Iss 2, Pp 100151- (2024)
Epigenetic modifications, including DNA methylation and histone post-translational modifications, intricately regulate gene expression patterns by influencing DNA accessibility and chromatin structure in higher organisms. These modifications are heri
Externí odkaz:
https://doaj.org/article/22d074ddc9164b66afb301575015ea3e