Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Histone Deacetylases / metabolism"'
Autor:
Ana Katušić-Bojanac, Milvija Plazibat, Marta Himelreich-Perić, Katarina Eck-Raković, Jure Krasić, Nino Sinčić, Gordana Jurić-Lekić, Davor Ježek, Floriana Bulić-Jakuš
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 16; Pages: 8861
The teratogenic activity of valproate (VPA), an antiepileptic and an inhibitor of histone deacetylase (HDACi), is dose-dependent in humans. Previous results showed that VPA impairs in vitro development and neural differentiation of the gastrulating e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94172e33185d6c105d2d22ab302ee8b
Autor:
Nico Fischer, Tina Dahlby, Melissa Koomen, Thomas Mandrup-Poulsen, Charna Dibner, Volodymyr Petrenko, Phillip Alexander Keller Andersen, Seyed Mojtaba Ghiasi, Peter Horskjær Rose
Publikováno v:
International Journal of Molecular Sciences
Andersen, P A K, Petrenko, V, Rose, P H, Koomen, M, Fischer, N, Ghiasi, S M, Dahlby, T, Dibner, C & Mandrup-Poulsen, T 2021, ' Proinflammatory cytokines perturb mouse and human pancreatic islet circadian rhythmicity and induce uncoordinated β-cell clock gene expression via nitric oxide, lysine deacetylases, and immunoproteasomal activity ', International Journal of Molecular Sciences, vol. 22, no. 1, 83, pp. 1-25 . https://doi.org/10.3390/ijms22010083
International Journal of Molecular Sciences, Vol. 22, No 1 (2020) P. 83
Volume 22
Issue 1
International Journal of Molecular Sciences, Vol 22, Iss 83, p 83 (2021)
Andersen, P A K, Petrenko, V, Rose, P H, Koomen, M, Fischer, N, Ghiasi, S M, Dahlby, T, Dibner, C & Mandrup-Poulsen, T 2021, ' Proinflammatory cytokines perturb mouse and human pancreatic islet circadian rhythmicity and induce uncoordinated β-cell clock gene expression via nitric oxide, lysine deacetylases, and immunoproteasomal activity ', International Journal of Molecular Sciences, vol. 22, no. 1, 83, pp. 1-25 . https://doi.org/10.3390/ijms22010083
International Journal of Molecular Sciences, Vol. 22, No 1 (2020) P. 83
Volume 22
Issue 1
International Journal of Molecular Sciences, Vol 22, Iss 83, p 83 (2021)
Pancreatic &beta
cell-specific clock knockout mice develop &beta
cell oxidative-stress and failure, as well as glucose-intolerance. How inflammatory stress affects the cellular clock is under-investigated. Real-time recording of Per2:lucife
cell-specific clock knockout mice develop &beta
cell oxidative-stress and failure, as well as glucose-intolerance. How inflammatory stress affects the cellular clock is under-investigated. Real-time recording of Per2:lucife
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57f713196105e260c2898cb08ff9e574
http://europepmc.org/articles/PMC7795908
http://europepmc.org/articles/PMC7795908
Autor:
Raymond J. Pierce, Wolfgang Sippl, Julien Lancelot, Karin Schmidtkunz, Alokta Chakrabarti, Dina Robaa, Jelena Melesina, Tajith B. Shaik, Christophe Romier, Conrad V. Simoben, Manfred Jung, Srinivasaraghavan Kannan, Martin Marek
Publikováno v:
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules
Molecules, 2018, 23 (3), pp.566. ⟨10.3390/molecules23030566⟩
Molecules, Vol 23, Iss 3, p 566 (2018)
Molecules; Volume 23; Issue 3; Pages: 566
Molecules, MDPI, 2018, 23 (3), pp.566. ⟨10.3390/molecules23030566⟩
Molecules
Molecules, 2018, 23 (3), pp.566. ⟨10.3390/molecules23030566⟩
Molecules, Vol 23, Iss 3, p 566 (2018)
Molecules; Volume 23; Issue 3; Pages: 566
Molecules, MDPI, 2018, 23 (3), pp.566. ⟨10.3390/molecules23030566⟩
International audience; A promising means in the search of new small molecules for the treatment of schistosomiasis (amongst other parasitic ailments) is by targeting the parasitic epigenome. In the present study, a docking based virtual screening pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c57756972e5c4439f4e393638be3994b
http://europepmc.org/articles/PMC6017931
http://europepmc.org/articles/PMC6017931
Autor:
Tasset, Celine, Singh Yadav, Avilash, Sureshkumar, Sridevi, Singh, Rupali, van der Woude, Lennard, Nekrasov, Maxim, Tremethick, David, van Zanten, Martijn, Balasubramanian, Sureshkumar, Sub Molecular Plant Physiology, Molecular Plant Physiology
Publikováno v:
PLoS Genetics, Vol 14, Iss 3, p e1007280 (2018)
PLoS Genetics, 14(3). Public Library of Science
PLoS Genetics
PLoS Genetics, 14(3). Public Library of Science
PLoS Genetics
Ambient temperature affects plant growth and even minor changes can substantially impact crop yields. The underlying mechanisms of temperature perception and response are just beginning to emerge. Chromatin remodeling, via the eviction of the histone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d57a60975b88b4bf219bb7925e75a4bb
https://doi.org/10.1101/186916
https://doi.org/10.1101/186916
Publikováno v:
Cardiovascular Research, Vol. 90, No 3 (2011) pp. 457-63
Cardiovascular research
Cardiovascular research
Aims Tissue-type plasminogen activator (t-PA) is produced by endothelial cells (EC) and is responsible for the removal of intravascular fibrin deposits. We investigated whether expression of t-PA by EC is under epigenetic control. Methods and results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d74d00f0995ff382c4671138dfe0327
http://doc.rero.ch/record/296785/files/cvr028.pdf
http://doc.rero.ch/record/296785/files/cvr028.pdf
Autor:
Scott W. Hiebert, Emma De Fabiani, Cinzia Magagnotti, Erika Fiorino, Donatella Caruso, Béatrice Desvergne, Annapaola Andolfo, Maurizio Crestani, Rui Silva, Gaia Cermenati, Nico Mitro, Federica Gilardi, Raffaella Longo, Alessandra Ferrari
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Nature Communications
Nature Communications, vol. 8, no. 1, pp. 93
Nature Communications
Nature Communications, vol. 8, no. 1, pp. 93
White adipose tissue (WAT) can undergo a phenotypic switch, known as browning, in response to environmental stimuli such as cold. Post-translational modifications of histones have been shown to regulate cellular energy metabolism, but their role in w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c512383fec48820206bfc3269b78fc0b
https://doi.org/10.1038/s41467-017-00182-7
https://doi.org/10.1038/s41467-017-00182-7
Publikováno v:
Biochemistry and Cell Biology
Biochemistry and Cell Biology, NRC Research Press, 2014, 92 (1), pp.61-7. ⟨10.1139/bcb-2013-0071⟩
Biochemistry and Cell Biology, NRC Research Press, 2014, 92 (1), pp.61-7. ⟨10.1139/bcb-2013-0071⟩
International audience; Besides its direct metabolic effects, insulin induces transcriptional alterations in its target tissues. However, whether such changes are accompanied by epigenetic changes on the chromatin template encompassing insulin respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313ee74892e18d034649a649e0cef462
https://doi.org/10.1139/bcb-2013-0071
https://doi.org/10.1139/bcb-2013-0071
Autor:
Finn K. Hansen, Christophe Romier, Linda Marek, Martin Marek, Manfred Jung, Christoph G. W. Gertzen, Johanna Senger, Katharina Stenzel, Viktoria Marquardt, Marc Remke, Thomas Kurz, Alexandra Hamacher, Holger Gohlke, Matthias U. Kassack
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2017, 60 (13), pp.5334-5348. ⟨10.1021/acs.jmedchem.6b01538⟩
Journal of Medicinal Chemistry, American Chemical Society, 2017, 60 (13), pp.5334-5348. ⟨10.1021/acs.jmedchem.6b01538⟩
The synthesis and biological evaluation of potent hydroxamate-based dual HDAC1/6 inhibitors with modest HDAC6 preference and a novel alkoxyurea connecting unit linker region are described. The biological studies included the evaluation of antiprolife
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fae45bc45d6f85c20596af1b3e2cbe58
https://hal.archives-ouvertes.fr/hal-03691179
https://hal.archives-ouvertes.fr/hal-03691179
Autor:
Vincent, Zwick, Pierre-Marie, Allard, Lucie, Ory, Claudia A, Simões-Pires, Laurence, Marcourt, Katia, Gindro, Jean-Luc, Wolfender, Muriel, Cuendet
Publikováno v:
Phytochemical Analysis, Vol. 28, No 2 (2017) pp. 93-100
Histone deacetylases (HDAC) are considered as promising targets for cancer treatment. Today, four HDAC inhibitors, vorinostat, romidepsin, belinostat, and panobinostat, have been approved by the Food and Drug Administration (FDA) for cancer treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7d23d944ae6a405da182e153d0412746
https://archive-ouverte.unige.ch/unige:94971
https://archive-ouverte.unige.ch/unige:94971
Autor:
Victor Fernandes Vieira, Sandrine Cornaz, Luisa Cironi, Carlo Fusco, Paolo Provero, Giulia Fregni, Ivan Stamenkovic, Igor Letovanec, Michel Aguet, Tanja Petricevic
Publikováno v:
Scientific Reports
Scientific reports, vol. 6, pp. 22113
Scientific reports, vol. 6, pp. 22113
Expression of the SS18/SYT-SSX fusion protein is believed to underlie the pathogenesis of synovial sarcoma (SS). Recent evidence suggests that deregulation of the Wnt pathway may play an important role in SS but the mechanisms whereby SS18-SSX might
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60efadcc1928d9d1f484ba21cc89d788
https://doi.org/10.1038/srep22113
https://doi.org/10.1038/srep22113