Polygenic scoring accuracy varies across the genetic ancestry continuum

Autor: Yi Ding, Kangcheng Hou, Ziqi Xu, Aditya Pimplaskar, Ella Petter, Kristin Boulier, Florian Privé, Bjarni J. Vilhjálmsson, Loes M. Olde Loohuis, Bogdan Pasaniuc

Publikováno v: Nature, vol 618, iss 7966
Ding, Y, Hou, K, Xu, Z, Pimplaskar, A, Petter, E, Boulier, K, Privé, F, Vilhjálmsson, B J, Olde Loohuis, L M & Pasaniuc, B 2023, ' Polygenic scoring accuracy varies across the genetic ancestry continuum ', Nature, vol. 618, pp. 774-781 . https://doi.org/10.1038/s41586-023-06079-4

Polygenic scores (PGSs) have limited portability across different groupings of individuals (for example, by genetic ancestries and/or social determinants of health), preventing their equitable use1–3. PGS portability has typically been assessed usi

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https://escholarship.org/uc/item/4m17p3jq