Supplementation with a 9c,11t-rich conjugated linoleic acid blend shows no clear inhibitory effects on platelet function in healthy subjects at low and moderate cardiovascular risk: A randomized controlled trial

Autor: Hiskias G Keizer, Graham W. Horgan, Sharon Wood, Eva-Maria Bachmair, Baukje de Roos, Isobel Ford

Publikováno v: Molecular Nutrition & Food Research. 59:741-750

cope The 9cis,11trans-conjugated linoleic acid (9c,11t-CLA) is reported to have anti-atherogenic properties in animal models and to modulate protein expression in unstimulated human platelets in vivo. Platelet function was therefore investigated afte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a574b0010e2d16b148682862586ffd5
https://doi.org/10.1002/mnfr.201400495

Pomegranate seed oil, a rich source of punicic acid, prevents diet-induced obesity and insulin resistance in mice

Autor: Raquel Hontecillas, Louis M. Havekes, Peter J. Voshol, Irene O.C.M. Vroegrijk, Luisa Gambelli, Gerben Zondag, Janna A. van Diepen, Sjoerd A.A. van den Berg, Johannes A. Romijn, Josep Bassaganya-Riera, Hiskias G. Keizer, Irene Westbroek

Publikováno v: Food and Chemical Toxicology, 49, 1426-30
Food and Chemical Toxicology, 49, 6, pp. 1426-30
Food and chemical toxicology, 49(6), 1426-1430. Elsevier Limited
Food and Chemical Toxicology; Vol 49
Food and Chemical Toxicology

Item does not contain fulltext BACKGROUND: Pomegranate seed oil has been shown to protect against diet induced obesity and insulin resistance. OBJECTIVE: To characterize the metabolic effects of punicic acid on high fat diet induced obesity and insul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75b466869fe4fd83dd4e11202d153052
https://doi.org/10.1016/j.fct.2011.03.037

Bioisosteric Replacements of the Pyrazole Moiety of Rimonabant: Synthesis, Biological Properties, and Molecular Modeling Investigations of Thiazoles, Triazoles, and Imidazoles as Potent and Selective CB1 Cannabinoid Receptor Antagonists

Autor: Peter C Verveer, Herman H. van Stuivenberg, Josephus H. M. Lange, Wouter de Looff, Alice J.M. Borst, Willem Veerman, Hiskias G. Keizer, Hein K. A. C. Coolen, Andrew C. McCreary, Henri C. Wals, Chris G. Kruse, Tiny J.P. Adolfs

Publikováno v: Journal of Medicinal Chemistry. 48:1823-1838

Series of thiazoles, triazoles, and imidazoles were designed as bioisosteres, based on the 1,5-diarylpyrazole motif that is present in the potent CB(1) receptor antagonist rimonabant (SR141716A, 1). A number of target compounds was synthesized and ev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efcd4c8ade0a6c0b52c26817f2895e9e
https://doi.org/10.1021/jm040843r

The 'Mevalonate hypothesis': a cholesterol-independent alternative for the etiology of atherosclerosis

Autor: Hiskias G. Keizer

Publikováno v: Lipids in Health and Disease
Lipids in Health and Disease, Vol 11, Iss 1, p 149 (2012)

The “cholesterol hypothesis” is the leading theory to explain the cause of atherosclerosis. The “cholesterol hypothesis” assumes that plasma (LDL) cholesterol is an important causal factor for atherosclerosis. However, data of at least seven

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f2ab4bad460e59774aa4b27ff98080a
https://doi.org/10.1186/1476-511x-11-149

Changes in subcellular doxorubicin distribution and cellular accumulation alone can largely account for doxorubicin resistance in SW-1573 lung cancer and MCF-7 breast cancer multidrug resistant tumour cells

Autor: Jan Lankelma, Hiskias G. Keizer, Herbert M. Pinedo, J.P.A. Baak, A. Cervantes, T. H. M. van Heijningen, J.H.M. de Lange, Gerrit Jan Schuurhuis, H. J. Broxterman

Publikováno v: British Journal of Cancer
Schuurhuis, G J, van Heijningen, T H M, Cervantes, A, Pinedo, H M, de Lange, J H M, Keizer, H G, Broxterman, H J, Baak, J P A & Lankelma, J 1993, ' Changes in subcellular doxorubicin distribution and cellular accumulation alone can largely account for doxorubicin resistance in SW-1573 lung cancer and MCF-7 breast cancer multidrug resistant tumour cells ', British Journal of Cancer, vol. 68, pp. 898-908 .
British Journal of Cancer, 68, 898-908. Nature Publishing Group

Doxorubicin accumulation defects in multidrug resistant tumour cells are generally small in comparison to the resistance factors. Therefore additional mechanisms must be operative. In this paper we show by a quantitative approach that doxorubicin res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc79be9041a60f64dde6ea4fcae05c1b
https://doi.org/10.1038/bjc.1993.452