Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Hisham K Hamadeh"'
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0204378 (2019)
Safety pharmacology screening against a wide range of unintended vital targets using in vitro assays is crucial to understand off-target interactions with drug candidates. With the increasing demand for in vitro assays, ligand- and structure-based vi
Externí odkaz:
https://doaj.org/article/6833dd8d7ad5434e8b5e99b05a0ad5d1
Autor:
Yudong D He, Christine M Karbowski, Jon Werner, Nancy Everds, Chris Di Palma, Yuan Chen, Marnie Higgins-Garn, Sandra Tran, Cynthia A Afshari, Hisham K Hamadeh
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88750 (2014)
Gene expression profiling is a tool to gain mechanistic understanding of adverse effects in response to compound exposure. However, little is known about how the common handling procedures of experimental animals during a preclinical study alter base
Externí odkaz:
https://doaj.org/article/0581c645f0774fb88b78327e2392f38d
Autor:
Caterina Vacchi-Suzzi, Yasmina Bauer, Brian R Berridge, Sandrine Bongiovanni, Kevin Gerrish, Hisham K Hamadeh, Martin Letzkus, Jonathan Lyon, Jonathan Moggs, Richard S Paules, François Pognan, Frank Staedtler, Martin P Vidgeon-Hart, Olivier Grenet, Philippe Couttet
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40395 (2012)
Anti-cancer therapy based on anthracyclines (DNA intercalating Topoisomerase II inhibitors) is limited by adverse effects of these compounds on the cardiovascular system, ultimately causing heart failure. Despite extensive investigations into the eff
Externí odkaz:
https://doaj.org/article/1bf1e6df5257478dabeac3b061a4a4f0
Autor:
M Ann Mongan, Robert T Dunn, Steven Vonderfecht, Nancy Everds, Guang Chen, Cheng Su, Marnie Higgins-Garn, Yuan Chen, Cynthia A Afshari, Toni L Williamson, Linda Carlock, Christopher Dipalma, Suzanne Moss, Jeanine Bussiere, Charles Qualls, Yudong D He, Hisham K Hamadeh
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15595 (2010)
Genome-wide gene expression profiling has become standard for assessing potential liabilities as well as for elucidating mechanisms of toxicity of drug candidates under development. Analysis of microarray data is often challenging due to the lack of
Externí odkaz:
https://doaj.org/article/6f64d4f7790f4d45ad6e4ed7980b8a19
Autor:
Shawn M. Sweeney, Hisham K. Hamadeh, Natalie Abrams, Stacey J. Adam, Sara Brenner, Dana E. Connors, Gerard J. Davis, Louis D. Fiore, Susan H. Gawel, Robert L. Grossman, Sean E. Hanlon, Karl Hsu, Gary J. Kelloff, Ilan R. Kirsch, Bill Louv, Deven McGraw, Frank Meng, Daniel Milgram, Robert S. Miller, Emily Morgan, Lata Mukundan, Thomas O'Brien, Paul Robbins, Eric H. Rubin, Wendy S. Rubinstein, Liz Salmi, Teilo H. Schaller, George Shi, Caroline C. Sigman, Sudhir Srivastava
Publikováno v:
Cancer Research. 83:1183-1190
The analysis of big healthcare data has enormous potential as a tool for advancing oncology drug development and patient treatment, particularly in the context of precision medicine. However, there are challenges in organizing, sharing, integrating,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9042c740550e4c3e4949faea3069c247
https://doi.org/10.1158/0008-5472.can-22-1277
https://doi.org/10.1158/0008-5472.can-22-1277
Autor:
Shawn M. Sweeney, Hisham K. Hamadeh, Natalie Abrams, Stacey J. Adam, Sara Brenner, Dana E. Connors, Gerard J. Davis, Louis Fiore, Susan H. Gawel, Robert L. Grossman, Sean E. Hanlon, Karl Hsu, Gary J. Kelloff, Ilan R. Kirsch, Bill Louv, Deven McGraw, Frank Meng, Daniel Milgram, Robert S. Miller, Emily Morgan, Lata Mukundan, Thomas O'Brien, Paul Robbins, Eric H. Rubin, Wendy S. Rubinstein, Liz Salmi, Teilo Schaller, George Shi, Caroline C. Sigman, Sudhir Srivastava
Publikováno v:
Cancer Research. 83:1175-1182
Big data in healthcare can enable unprecedented understanding of diseases and their treatment, particularly in oncology. These data may include electronic health records, medical imaging, genomic sequencing, payor records, and data from pharmaceutica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71f4d3e129a9c64d20c7837ca7bd3bb5
https://doi.org/10.1158/0008-5472.can-22-1274
https://doi.org/10.1158/0008-5472.can-22-1274
Autor:
Han Si, Steven Xu, Anantharaman Muthuswamy, Ryan Liang, Kate Sasser, Hisham K. Hamadeh, Suzana Couto, Brandon Higgs
Publikováno v:
Cancer Research. 82:459-459
Background: Pancreatic ductal adenocarcinoma (PDAC) has proven a difficult cancer to treat. To improve treatment strategies, molecular subtypes have been identified, one being immunogenic with significant immune infiltrate and better prognosis. These
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbb220881d9e7c82c2e8df62ca5fd113
https://doi.org/10.1158/1538-7445.am2022-459
https://doi.org/10.1158/1538-7445.am2022-459
Autor:
Yudong D. He, Efrain Pacheco, Hisham K. Hamadeh, Rogely Waite Boyce, Scott Taylor, Ian Pyrah, Michael S. Ominsky, Chris Paszty, Paul Nioi, Rong Hu
Publikováno v:
Journal of Bone and Mineral Research. 30:1457-1467
Sclerostin antibody (Scl-Ab) increases bone formation through a process dependent on the activation of canonical Wnt signaling, although the specific signaling in the osteoblast lineage in vivo is largely unknown. To gain insight into the signaling p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a00b51e0f7a6a6f85fe8249d6b66a33
https://doi.org/10.1002/jbmr.2482
https://doi.org/10.1002/jbmr.2482
Autor:
Simone Strauch, Hisham K. Hamadeh, Kerstin Weikl, Fan Fan, Anke Munzli, Paul Nioi, Cynthia A. Afshari, Ralf Schwandner, Yuan Chen, Robert T. Dunn, Rong Hu
Publikováno v:
Toxicological Sciences. 145:283-295
Off-target effects of drugs on nuclear hormone receptors (NHRs) may result in adverse effects in multiple organs/physiological processes. Reliable assessments of the NHR activities for drug candidates are therefore crucial for drug development. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba0665d99f159f7f941e3beccd202a3
https://doi.org/10.1093/toxsci/kfv052
https://doi.org/10.1093/toxsci/kfv052
Autor:
Ruth Lightfoot-Dunn, Roderick A. Capaldi, Padma K. Narayanan, Cynthia A. Afshari, Nianyu Li, J. Paul Robinson, Yudong D. He, Hisham K. Hamadeh, C. Elisa Oquendo
Publikováno v:
Toxicological Sciences. 142:261-273
Mitochondrial perturbation has been recognized as a contributing factor to various drug-induced organ toxicities. To address this issue, we developed a high-throughput flow cytometry-based mitochondrial signaling assay to systematically investigate m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eca9589f884f37577676d709a18c5e56
https://doi.org/10.1093/toxsci/kfu176
https://doi.org/10.1093/toxsci/kfu176