Zobrazeno 1 - 10
of 332
pro vyhledávání: '"Hisham, Mehanna"'
Autor:
Luisa Bresadola, David Weber, Christoph Ritzel, Martin Löwer, Valesca Bukur, Özlem Akilli-Öztürk, Christian Schuster, Alessandra Gargano, Julia Becker, Hisham Mehanna, Barbara Schrörs, Fulvia Vascotto, Ugur Sahin, Anthony Kong
Publikováno v:
BJC Reports, Vol 2, Iss 1, Pp 1-11 (2024)
Abstract Background Head and neck squamous cell carcinomas (HNSCCs) are heterogeneous in terms of origin and aetiology. In addition, there is uncertainty about the genetic evolution from initial diagnosis to recurrence after primary treatments and fu
Externí odkaz:
https://doaj.org/article/ca00f57f17a34a7da41ab466171b8575
Autor:
Paul Nankivell, Piers Gaunt, Claire Gaunt, Julia Sissons, Evaggelia Liaskou, Yolande Jefferson, Tessa Fulton-Lieuw, Saloni Mittal, Hisham Mehanna, PETNECK2 Research Team
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-13 (2024)
Abstract Background Approximately 40% of treated head and neck cancer (HNC) patients develop recurrence. The risk of recurrence declines with time from treatment. Current guidelines recommend clinical follow-up every two months for the first two year
Externí odkaz:
https://doaj.org/article/907199b2529a4794a0bf52c1030cc1ff
Autor:
Adam J. Shephard, Raja Muhammad Saad Bashir, Hanya Mahmood, Mostafa Jahanifar, Fayyaz Minhas, Shan E. Ahmed Raza, Kris D. McCombe, Stephanie G. Craig, Jacqueline James, Jill Brooks, Paul Nankivell, Hisham Mehanna, Syed Ali Khurram, Nasir M. Rajpoot
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-12 (2024)
Abstract Oral epithelial dysplasia (OED) is a premalignant histopathological diagnosis given to lesions of the oral cavity. Its grading suffers from significant inter-/intra-observer variability, and does not reliably predict malignancy progression,
Externí odkaz:
https://doaj.org/article/b26574c2f4f740f0b49bb221663a5412
Autor:
Jill M. Brooks, Yuanning Zheng, Kelly Hunter, Benjamin E. Willcox, Janet Dunn, Paul Nankivell, Olivier Gevaert, Hisham Mehanna
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundThe incidence of oropharyngeal cancer (OPC) is increasing, due mainly to a rise in Human Papilloma Virus (HPV)-mediated disease. HPV-mediated OPC has significantly better prognosis compared with HPV-negative OPC, stimulating interest in tre
Externí odkaz:
https://doaj.org/article/f12a3ff832bb48f7a7eb35b9911523e9
Autor:
Hisham Mehanna, Jonathan J Deeks, Kristien Boelaert, Gitta Madani, Paul Sidhu, Paul Nankivell, Neil Sharma, Rebecca Woolley, Judith Taylor, Tessa Fulton-Lieuw, Andrew Palmer
Publikováno v:
Health Technology Assessment, Vol 28, Iss 46 (2024)
Background Strain and shear wave elastography which is commonly used with concurrent real-time imaging known as real-time ultrasound shear/strain wave elastography is a new diagnostic technique that has been reported to be useful in the diagnosis of
Externí odkaz:
https://doaj.org/article/986143b4d54241d284f84397d22839a7
Autor:
Naeima Yahia Hendawi, Hannah L. Crane, Hisham Mehanna, Robert Bolt, Daniel W. Lambert, Keith D. Hunter
Publikováno v:
Frontiers in Oral Health, Vol 5 (2024)
IntroductionHPV-associated oropharyngeal squamous cell carcinoma (OPSCC) shows distinct biological and clinical behaviour when compared to HPV-negative OPSCC. The overall role of the tumour microenvironment (TME) in head and neck cancer progression a
Externí odkaz:
https://doaj.org/article/bc99b0e6511b4991bc55efd67054998a
Autor:
Hisham Mehanna, Piers Gaunt, Anthony Kong, Andrew Hartley, Paul Sanghera, Martin Forster, Mehmet Sen, Vinidh Paleri, Charles Fong, Dinos Geropantas, Devraj Srinivasan, Satya Garikipati, Rafael Moleron, Georgina Casswell, Eleanor Aynsley, Amy Ward, Lorcan O’Toole, Arafat Mirza, Charlotte Firth, Isla Humphreys, Tessa Fulton-Lieuw, Tom Roques, Paul Nankivell
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-17 (2024)
Abstract Background Patients with intermediate and high-risk oropharyngeal cancer (OPC) have poorer response to standard treatment and poorer overall survival compared to low-risk OPC. CompARE is designed to test alternative approaches to intensified
Externí odkaz:
https://doaj.org/article/330dec8870f14404b747cb77cc116ff3
Autor:
Amit Patel, Kristian Brock, Daniel Slade, Claire Gaunt, Anthony Kong, Hisham Mehanna, Lucinda Billingham, Piers Gaunt
Publikováno v:
BMC Medical Research Methodology, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background In this article we describe the methodology of the time-to-event continual reassessment method in the presence of partial orders (PO-TITE-CRM) and the process of implementing this trial design into a phase I trial in head and neck
Externí odkaz:
https://doaj.org/article/482169edd81b4cb08d5b3a47c93c2213
Autor:
Paul Nankivell, Piers Gaunt, Claire Gaunt, Julia Sissons, Evaggelia Liaskou, Yolande Jefferson, Tessa Fulton-Lieuw, Saloni Mittal, Hisham Mehanna, PETNECK2 Research Team
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/e20a71dcd14e4932945edc0364d459d6
Autor:
Karl F. B. Payne, Peter Brotherwood, Harini Suriyanarayanan, Jill M. Brooks, Nikolaos Batis, Andrew D. Beggs, Deena M. A. Gendoo, Hisham Mehanna, Paul Nankivell
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundAs circulating tumour DNA (ctDNA) liquid biopsy analysis is increasingly incorporated into modern oncological practice, establishing the impact of genomic intra-tumoural heterogeneity (ITH) upon data output is paramount. Despite advances in
Externí odkaz:
https://doaj.org/article/e05145d79eb243d7a8953e7b92d45ddb