Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Hisayuki Shigematsu"'
Autor:
Mikio Okazaki, Yoshifumi Sano, Yu Mori, Nobuhiko Sakao, Syungo Yukumi, Hisayuki Shigematsu, Hironori Izutani
Publikováno v:
Journal of Cardiothoracic Surgery, Vol 15, Iss 1, Pp 1-4 (2020)
Abstract Background Fluorodeoxyglucose (FDG)-positron emission tomography (PET)/CT is the most sensitive non-invasive imaging method for the detection of tumor metastasis and recurrence, but sometimes reveals false-positive results. Herein, we report
Externí odkaz:
https://doaj.org/article/fa01d5dc3f3e4d31a4a7a49aecaae6cd
Autor:
Junichi Soh, Naoki Okumura, William W Lockwood, Hiromasa Yamamoto, Hisayuki Shigematsu, Wei Zhang, Raj Chari, David S Shames, Ximing Tang, Calum MacAulay, Marileila Varella-Garcia, Tõnu Vooder, Ignacio I Wistuba, Stephen Lam, Rolf Brekken, Shinichi Toyooka, John D Minna, Wan L Lam, Adi F Gazdar
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7464 (2009)
Activating mutations in one allele of an oncogene (heterozygous mutations) are widely believed to be sufficient for tumorigenesis. However, mutant allele specific imbalance (MASI) has been observed in tumors and cell lines harboring mutations of onco
Externí odkaz:
https://doaj.org/article/53eaf768390c472a8fd407b76cdc3556
Autor:
Jeet Gandhi, Jianling Zhang, Yang Xie, Junichi Soh, Hisayuki Shigematsu, Wei Zhang, Hiromasa Yamamoto, Michael Peyton, Luc Girard, William W Lockwood, Wan L Lam, Marileila Varella-Garcia, John D Minna, Adi F Gazdar
Publikováno v:
PLoS ONE, Vol 4, Iss 2, p e4576 (2009)
BackgroundDeregulation of EGFR signaling is common in non-small cell lung cancers (NSCLC) and this finding led to the development of tyrosine kinase inhibitors (TKIs) that are highly effective in a subset of NSCLC. Mutations of EGFR (mEGFR) and copy
Externí odkaz:
https://doaj.org/article/d9163783124542469f9e57014990ffc7
Autor:
Masaharu Nomura, Hisayuki Shigematsu, Lin Li, Makoto Suzuki, Takao Takahashi, Pila Estess, Mark Siegelman, Ziding Feng, Harubumi Kato, Antonio Marchetti, Jerry W Shay, Margaret R Spitz, Ignacio I Wistuba, John D Minna, Adi F Gazdar
Publikováno v:
PLoS Medicine, Vol 4, Iss 4, p e125 (2007)
The epidermal growth factor receptor (EGFR) gene is the prototype member of the type I receptor tyrosine kinase (TK) family and plays a pivotal role in cell proliferation and differentiation. There are three well described polymorphisms that are asso
Externí odkaz:
https://doaj.org/article/bf5f3aeb4aee4b0f8a4cfea185b8ce06
Publikováno v:
PLoS Medicine, Vol 3, Iss 4, p e206 (2006)
Externí odkaz:
https://doaj.org/article/0762c83d5652429082728d20b98ab5fc
Autor:
Tsuyoshi Ryuko, Hiroshi Suehisa, Shinya Sakai, Takahito Sugihara, Shohei Nakashima, Tsuyoshi Ueno, Hisayuki Shigematsu, Motohiro Yamashita
Publikováno v:
The Journal of the Japanese Association for Chest Surgery. 37:85-92
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::974cab82c122877da983e3e04c75f031
https://doi.org/10.2995/jacsurg.37.85
https://doi.org/10.2995/jacsurg.37.85
Autor:
Adi F. Gazdar, John D. Minna, Wan L. Lam, Hiroshi Date, Shinichi Toyooka, Huei Lee, Kwun M. Fong, Ignacio I. Wistuba, Makoto Suzuki, Junichi Soh, Naoki Okumura, Mitsuo Sato, William W. Lockwood, Masaharu Nomura, Hisayuki Shigematsu, Hiromasa Yamamoto
Supplementary Methods from PIK3CA Mutations and Copy Number Gains in Human Lung Cancers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::178d28772b44e38552f071607ece2082
https://doi.org/10.1158/0008-5472.22375110
https://doi.org/10.1158/0008-5472.22375110
Autor:
Adi F. Gazdar, John D. Minna, Wan L. Lam, Hiroshi Date, Shinichi Toyooka, Huei Lee, Kwun M. Fong, Ignacio I. Wistuba, Makoto Suzuki, Junichi Soh, Naoki Okumura, Mitsuo Sato, William W. Lockwood, Masaharu Nomura, Hisayuki Shigematsu, Hiromasa Yamamoto
Supplementary Figure 1 from PIK3CA Mutations and Copy Number Gains in Human Lung Cancers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4706bfca71537c0327e93c6c1bde1370
https://doi.org/10.1158/0008-5472.22375113
https://doi.org/10.1158/0008-5472.22375113
Autor:
Adi F. Gazdar, John D. Minna, Wan L. Lam, Hiroshi Date, Shinichi Toyooka, Huei Lee, Kwun M. Fong, Ignacio I. Wistuba, Makoto Suzuki, Junichi Soh, Naoki Okumura, Mitsuo Sato, William W. Lockwood, Masaharu Nomura, Hisayuki Shigematsu, Hiromasa Yamamoto
We investigated the frequency and function of mutations and increased copy number of the PIK3CA gene in lung cancers. PIK3CA mutations are one of the most common gene changes present in human cancers. We analyzed the mutational status of exons 9 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e523df448c39ef5a470891da74b545d
https://doi.org/10.1158/0008-5472.c.6497715
https://doi.org/10.1158/0008-5472.c.6497715
Autor:
David B. Solit, Neal Rosen, Adi Gazdar, Marc Ladanyi, Shinichi Toyooka, William Pao, Barry S. Taylor, Manickam Janakiraman, Ayana Sawai, Hiromasa Yamamoto, Hisayuki Shigematsu, Dhananjay Chitale, Junichi Soh, Yogindra Persaud, Ensar Halilovic, Aphrothiti J. Hanrahan, Christine A. Pratilas
Supplementary Materials from Genetic Predictors of MEK Dependence in Non–Small Cell Lung Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d48bead40b73c2410daffc0d6f0af94
https://doi.org/10.1158/0008-5472.22375757
https://doi.org/10.1158/0008-5472.22375757