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pro vyhledávání: '"Hisatoshi Tsuchida"'
Autor:
Takashi Komine, Muneki Nagao, Hiroyasu Takahashi, Masashi Suzuki, Koichi Katsuyama, Mariko Shinoyama, Hisatoshi Tsuchida
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(6)
Synthesis, and structure-activity relationship (SAR) studies of the novel IKK-β inhibitors 2 and 3 characterized by a dihydrothieno[2,3-e]indazole core are presented. Compound 2t was efficacious in a mouse model of LPS-stimulated TNF-α production.
Autor:
Hisatoshi Tsuchida, Yasushi Ohizumi
Publikováno v:
European journal of pharmacology. 477(1)
The effects of (+)-nantenine on various pressor responses, recently reported exerting competitive antagonistic activity at the alpha1-adrenoceptor/5-hydroxytryptamine (5-HT)2A receptor, were examined in vivo. (+)-Nantenine (0.03-3 mg/kg) caused a dos
Publikováno v:
HETEROCYCLES. 11:351