Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Hisataka Yamazaki"'
Autor:
Daisuke Yamamuro, Hisataka Yamazaki, Jun-ichi Osuga, Kenta Okada, Tetsuji Wakabayashi, Akihito Takei, Shoko Takei, Manabu Takahashi, Shuichi Nagashima, Adriaan G. Holleboom, Masayuki Kuroda, Hideaki Bujo, Shun Ishibashi
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 9, Pp 1287-1299 (2020)
The acyltransferase LCAT mediates FA esterification of plasma cholesterol. In vitro studies have shown that LCAT also FA-esterifies several oxysterols, but in vivo evidence is lacking. Here, we measured both free and FA-esterified forms of sterols in
Externí odkaz:
https://doaj.org/article/7b302d366e724dc48d0fc049e847b5aa
Autor:
Daisuke Yamamuro, Manabu Takahashi, Shuichi Nagashima, Tetsuji Wakabayashi, Hisataka Yamazaki, Akihito Takei, Shoko Takei, Kent Sakai, Ken Ebihara, Yusaku Iwasaki, Toshihiko Yada, Shun Ishibashi
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0234439 (2020)
Disturbance of circadian rhythms underlies various metabolic diseases. Constant light exposure (LL) is known to disrupt both central and peripheral circadian rhythms. Here, we attempted to determine whether the effects of LL are different between var
Externí odkaz:
https://doaj.org/article/c9cfb78d74064476bf1ae474b21160fd
Autor:
Hideaki Bujo, Akihito Takei, Hisataka Yamazaki, Jun-ichi Osuga, Shoko Takei, Manabu Takahashi, Masayuki Kuroda, Adriaan G. Holleboom, Shuichi Nagashima, Tetsuji Wakabayashi, Shun Ishibashi, Daisuke Yamamuro, Kenta Okada
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 9, Pp 1287-1299 (2020)
J Lipid Res
Journal of lipid research, 61(9), 1287-1299. American Society for Biochemistry and Molecular Biology Inc.
J Lipid Res
Journal of lipid research, 61(9), 1287-1299. American Society for Biochemistry and Molecular Biology Inc.
The acyltransferase LCAT mediates FA esterification of plasma cholesterol. In vitro studies have shown that LCAT also FA-esterifies several oxysterols, but in vivo evidence is lacking. Here, we measured both free and FA-esterified forms of sterols in
Autor:
Manabu Takahashi, Daisuke Yamamuro, Chihiro Ebihara, Masayo Isoda, Hisataka Yamazaki, Shuichi Nagashima, Shoko Takei, Ken Ebihara, Akihito Takei, Tetsuji Wakabayashi, Akiko Murakami, Shun Ishibashi
Publikováno v:
Diabetes. 69:158-164
Adipose tissue macrophages (ATMs) are involved in the development of insulin resistance in obesity. We have recently shown that myeloid cell-specific reduction of 3- hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcrm-/m-), which is the rate-limiti
Autor:
Ken Ebihara, Manabu Takahashi, Shuichi Nagashima, Shoko Takei, Tadayoshi Karasawa, Masafumi Takahashi, Daisuke Yamamuro, Akihito Takei, Tetsuji Wakabayashi, Shun Ishibashi, Hisataka Yamazaki
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 38:2576-2589
Objective— ACAT1 (Acyl-CoA cholesterol acyltransferase 1) esterifies cellular free cholesterol, thereby converting macrophages to cholesteryl ester-laden foam cells in atherosclerotic lesions and cutaneous xanthoma. Paradoxically, however, loss of
Autor:
Shun Ishibashi, Takashi Yashiro, Ken Fujiwara, Tatsushi Onaka, Yuki Takayanagi, Katsuya Dezaki, Ken Ebihara, Manabu Takahashi, Chihiro Ebihara, Hisataka Yamazaki, Masayo Isoda, Akiko Murakami, Tetsuji Wakabayashi, Daisuke Yamamuro, Akihito Takei, Shuichi Nagashima, Shoko Takei, Ada Admin
Inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), statins, which are used to prevent cardiovascular diseases, are associated with a modest increase in the risk of new-onset diabetes mellitus. To investigate the role of HMGCR in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1acf6010983f8e067fe3e926ac686cd0
https://doi.org/10.2337/figshare.12771422
https://doi.org/10.2337/figshare.12771422
Autor:
Toshihiko Yada, Manabu Takahashi, Yusaku Iwasaki, Shoko Takei, Tetsuji Wakabayashi, Ken Ebihara, Daisuke Yamamuro, Kent Sakai, Shun Ishibashi, Akihito Takei, Shuichi Nagashima, Hisataka Yamazaki
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0234439 (2020)
PLoS ONE
PLoS ONE
Disturbance of circadian rhythms underlies various metabolic diseases. Constant light exposure (LL) is known to disrupt both central and peripheral circadian rhythms. Here, we attempted to determine whether the effects of LL are different between var
Publikováno v:
Int. Journal of Clinical Pharmacology and Therapeutics. 54:1004-1008
OBJECTIVE The aim of the present study was to investigate the efficacy and safety of ipragliflozin treatment on glycemic control in patients with type 2 diabetes mellitus (T2DM). METHODS We recruited 44 patients with T2DM, treated them with 50 mg/day
Autor:
Tetsuji Wakabayashi, Shun Ishibashi, Takashi Yashiro, Daisuke Yamamuro, Masayo Isoda, Chihiro Ebihara, Manabu Takahashi, Akihito Takei, Katsuya Dezaki, Ken Fujiwara, Hisataka Yamazaki, Akiko Murakami, Ken Ebihara, Shoko Takei, Tatsushi Onaka, Shuichi Nagashima, Yuki Takayanagi
Publikováno v:
Diabetes. 69(11)
Inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), statins, which are used to prevent cardiovascular diseases, are associated with a modest increase in the risk of new-onset diabetes. To investigate the role of HMGCR in the development o
Autor:
Shoko Takei, Akihito Takei, Manabu Takahashi, Shin-ichi Tominaga, Hiroko Hayakawa, Shun Ishibashi, Tadayoshi Karasawa, Hisataka Yamazaki, Ken Ohashi, Jun-ichi Osuga, Kent Sakai, Daisuke Yamamuro, Bayasgalan Tumenbayar, Masafumi Takahashi, Tetsuji Wakabayashi, Hiroaki Yagyu, Morisada Hayakawa, Shuichi Nagashima
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 38(11)
Objective— Inhibition of HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase) is atheroprotective primarily by decreasing plasma LDL (low-density lipoprotein)-cholesterol. However, it is unknown whether inhibition of HMGCR in myeloid cells contr