Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Hisataka Awata"'
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Interaction of the Calcium-sensing Receptor and Filamin, a Potential Scaffolding Protein
Autor: R. Tyler Miller, Hisataka Awata, Chunfa Huang, Mary E. Handlogten
Publikováno v: Journal of Biological Chemistry. 276:34871-34879
In many cases, the biologic responses of cells to extracellular signals and the specificity of the responses cannot be explained solely on the basis of the interactions of known signaling proteins. Recently, scaffolding and adaptor proteins have been
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cc8bab6be9ed91a7f4ff299d04786d9
https://doi.org/10.1074/jbc.m100775200
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3
Extracellular Ca2+-sensing receptor is a promiscuous divalent cation sensor that responds to lead
Autor: Naoki Shiraishi, R. Tyler Miller, Mary E. Handlogten, Chunfa Huang, Hisataka Awata
Publikováno v: American Journal of Physiology-Renal Physiology. 279:F1083-F1091
The extracellular Ca2+-sensing receptor (CaR) responds to polycations, including Ca2+and neomycin. This receptor is a physiological regulator of systemic Ca2+metabolism and may also mediate the toxic effects of hypercalcemia. A number of divalent cat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a9e9024c08f5fc4a1379de9890bda02
https://doi.org/10.1152/ajprenal.2000.279.6.f1083
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4
A Mouse Model of Renal Tubular Injury of Tyrosinemia Type 1
Autor: Fumio Endo, Ichiro Matsuda, Shinzaburo Hattori, Hisataka Awata, Mao Sen Sun, Shuji Kubo
Publikováno v: Journal of the American Society of Nephrology. 11:291-300
Hereditary tyrosinemia type 1 (HT1) (McKusick 276700), a severe autosomal recessive disorder of tyrosine metabolism, is caused by mutations in the fumarylacetoacetate hydrolase gene Fah (EC 3.7.1.2), which encodes the last enzyme in the tyrosine cata
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82520e05ce9f8581392024ed84b0f709
https://doi.org/10.1681/asn.v112291
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5
Complete Rescue of Lethal Albino c Mice by Null Mutation of 4-Hydroxyphenylpyruvate Dioxygenase and Induction of Apoptosis of Hepatocytes in These Mice by in VivoRetrieval of the Tyrosine Catabolic Pathway
Autor: Izumu Saito, Ichiro Matsuda, Shuji Kubo, Hisataka Awata, Yumi Kanegae, Fumio Endo, Koji Kiwaki, Shinzaburo Hattori, Cornelis Jakobs, Jun Ichi Miyazaki, Hideki Katoh, Tetsuro Yamamoto
Publikováno v: Journal of Biological Chemistry. 272:24426-24432
Hereditary tyrosinemia 1 (HT1) is characterized by progressive liver damage, from infancy, and by a high risk for hepatocellular carcinoma. HT1 is due to mutations in the fumarylacetoacetate hydrolase gene Fah, encoding the last enzyme in the tyrosin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e6f788c9ae23253b06975220bf0f77f
https://doi.org/10.1074/jbc.272.39.24426
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6
15-Deoxy-Δ12,14-prostaglandin J2 induces PPARγ- and p53-independent apoptosis in rabbit synovial cells
Autor: Tetsuji Kawakami, Toshiaki Morisugi, Yukiko Sakaba, Hisataka Awata, Akikazu Sakudo, Yasuharu Tanaka
Publikováno v: Prostaglandinsother lipid mediators.
A ligand of peroxisome proliferator-activated receptor γ (PPARγ), 15-deoxy-Δ(12,14)-prostaglandin J2 (15d-PGJ2) induces apoptosis in various cells. However, the mechanism appears to be complex and cell-type specific. We investigated the mechanism
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5566a5d78856c4312d91c82230aa9a4e
https://pubmed.ncbi.nlm.nih.gov/24680891
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8
Structural organization and analysis of the human fumarylacetoacetate hydrolase gene in tyrosinemia type I
Autor: Yoshikuni Nakano, Ichiro Matsuda, Fumio Endo, A. Kitano, Hisataka Awata, Akito Tanoue
Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1226:168-172
Fumarylacetoacetate hydrolase (FAH) is a metabolic enzyme functioning at the last step of tyrosine catabolism. Deficiency in this enzyme activity is associated with tyrosinemia type I, characterized by hypertyrosinemia, liver dysfunction, renal tubul
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ea4eb5e48f294e5cc30dfe13a7d023
https://doi.org/10.1016/0925-4439(94)90025-6
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9
Primary structure deduced from complementary DNA sequence and expression in cultured cells of mammalian 4-hydroxyphenylpyruvic acid dioxygenase. Evidence that the enzyme is a homodimer of identical subunits homologous to rat liver-specific alloantigen F
Autor: Hisataka Awata, Koiti Titani, Ichiro Matsuda, Mariko Ishiguro, Fumio Endo, Akito Tanoue, Yasuyuki Eda
Publikováno v: Journal of Biological Chemistry. 267:24235-24240
4-Hydroxyphenylpyruvic acid dioxygenase is an important enzyme in tyrosine catabolism in most organisms. From porcine and human liver cDNA libraries we isolated complementary DNA inserts for the enzyme. Protein sequence analysis of the porcine enzyme
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::764e508fd6d730440b017a5e46195858
https://doi.org/10.1016/s0021-9258(18)35755-7
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10
The Ca2+-sensing receptor activates cytosolic phospholipase A2 via a Gqalpha -dependent ERK-independent pathway
Autor: Mary E. Handlogten, Naoki Shiraishi, Hisataka Awata, R. Tyler Miller, Chunfa Huang
Publikováno v: The Journal of biological chemistry. 276(17)
The Ca(2+)-sensing receptor (CaR) stimulates a number of phospholipase activities, but the specific phospholipases and the mechanisms by which the CaR activates them are not defined. We investigated regulation of phospholipase A(2) (PLA(2)) by the Ca
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::193d1c98b4962f8d1e1bf78eb20f29ad
https://pubmed.ncbi.nlm.nih.gov/11278341
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