Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Hisashi Ohno"'
1
Akademický článek
Discovery of a cystathionine γ-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5′-phosphate (PLP) via Schiff base formation
Autor: Honami Echizen, Kenjiro Hanaoka, Kazuhito Shimamoto, Ryota Hibi, Sachiko Toma-Fukai, Hisashi Ohno, Eita Sasaki, Toru Komatsu, Tasuku Ueno, Yukihiro Tsuchiya, Yasuo Watanabe, Takao Otsuka, Hiroaki Saito, Satoru Nagatoishi, Kouhei Tsumoto, Hirotatsu Kojima, Takayoshi Okabe, Toshiyuki Shimizu, Yasuteru Urano
Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract D,L-Propargylglycine (PAG) has been widely used as a selective inhibitor to investigate the biological functions of cystathionine γ-lyase (CSE), which catalyzes the formation of reactive sulfur species (RSS). However, PAG also inhibits othe
Externí odkaz: https://doaj.org/article/90eed93fe0d34640b472dbfd8bff78fa
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2
Akademický článek
Amide nitrogen pyramidalization changes lactam amide spinning
Autor: Yuko Otani, Xin Liu, Hisashi Ohno, Siyuan Wang, Luhan Zhai, Aoze Su, Masatoshi Kawahata, Kentaro Yamaguchi, Tomohiko Ohwada
Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Cis-trans lactam amide rotation is a fundamental process and its understanding might aid molecular design. Here, the authors report the synthesis and study of bicyclic lactams which undergo spin through 360 degrees as in open-chain amides, due to the
Externí odkaz: https://doaj.org/article/abbe06c5c40d47119ae8d500e4816855
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3
General Design Strategy to Precisely Control the Emission of Fluorophores via a Twisted Intramolecular Charge Transfer (TICT) Process
Autor: Kenjiro Hanaoka, Shimpei Iwaki, Kiyoshi Yagi, Takuya Myochin, Takayuki Ikeno, Hisashi Ohno, Eita Sasaki, Toru Komatsu, Tasuku Ueno, Motokazu Uchigashima, Takayasu Mikuni, Kazuki Tainaka, Shinya Tahara, Satoshi Takeuchi, Tahei Tahara, Masanobu Uchiyama, Tetsuo Nagano, Yasuteru Urano
Publikováno v: Journal of the American Chemical Society. 144:19778-19790
Fluorogenic probes for bioimaging have become essential tools for life science and medicine, and the key to their development is a precise understanding of the mechanisms available for fluorescence off/on control, such as photoinduced electron transf
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb0faea991add1d0b00aa35c9beea5ef
https://doi.org/10.1021/jacs.2c06397
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4
Amide nitrogen pyramidalization changes lactam amide spinning
Autor: Tomohiko Ohwada, Kentaro Yamaguchi, Aoze Su, Hisashi Ohno, Yuko Otani, Luhan Zhai, Xin Liu, Siyuan Wang, Masatoshi Kawahata
Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Nature Communications
Although cis-trans lactam amide rotation is fundamentally important, it has been little studied, except for a report on peptide-based lactams. Here, we find a consistent relationship between the lactam amide cis/trans ratios and the rotation rates be
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c5eaa513415f86098325805807fdbb
http://link.springer.com/article/10.1038/s41467-018-08249-9
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