Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Hisashi Iwaasa"'
Autor:
Toshihiro Sakamoto, Hisashi Iwaasa, Minoru Moriya, Takunobu Shibata, Masato Chiba, Tomoyuki Ohe, Takehiro Fukami, Yuko Mitobe, Akio Kanatani, Alcane Ishihara, Yasuyuki Ishii, Hidefumi Kitazawa, Hirobumi Takahashi, Katsumasa Nonoshita, Yuji Haga
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5436-5439
A series of trans -3-oxospiro[(aza)isobenzofuran-1(3 H ),1′-cyclohexane]-4′-carboxamide derivatives were synthesized and profiled for NPY Y5 binding affinity, brain and CSF penetrability in rats, and susceptibility to human and mouse P-glycoprote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f4cfe3bcba37700c1a787719176e94
https://doi.org/10.1016/j.bmcl.2009.07.103
https://doi.org/10.1016/j.bmcl.2009.07.103
Autor:
Akane Ishihara, Fukami Takehiro, Toshiyuki Takahashi, Takashi Murai, Satoshi Mashiko, Junko Ito, Ryuichi Moriya, Zenjun Oda, Yuko Mitobe, Akio Kanatani, Hisashi Iwaasa
Publikováno v:
Peptides. 30:1318-1322
Neuropeptide Y (NPY) and its family of peptides are thought to have a major role in the physiological control of energy homeostasis. Among five NPY receptors described, stimulation of the Y2 receptor (Y2R) or inhibition of the Y5 receptor (Y5R) has r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e8fa1144a153991cde95f47e3922b3
https://doi.org/10.1016/j.peptides.2009.04.006
https://doi.org/10.1016/j.peptides.2009.04.006
Autor:
Hisashi Ohta, Akio Kanatani, Hiroko Matsushita, Akane Ishihara, Hisashi Iwaasa, Takeshi Tanaka, Tetsuya Kanno, Satoshi Mashiko
Publikováno v:
Endocrinology. 150:2668-2673
Nociceptin/orphanin FQ (N/OFQ), an endogenous ligand for opioid receptor-like 1 (ORL1), is involved in various central functions, such as pain, psychological stress, locomotor activity, learning and memory, and feeding regulation. Of these functions,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c99b928263caaf6c3a0639d292a43b4
https://doi.org/10.1210/en.2008-1515
https://doi.org/10.1210/en.2008-1515
Autor:
Nagaaki Sato, Akio Kanatani, Akane Ishihara, Hiroyasu Tsuge, Akira Gomori, Shiho Ishikawa, Keita Nagai, Osamu Okamoto, Makoto Ando, Makoto Jitsuoka, Hisashi Iwaasa, Takehiro Fukami
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1670-1674
Novel imidazoline derivatives were discovered to be potent neuropeptide Y Y5 receptor antagonists. High-throughput screening of Merck sample collections against the human Y5 receptor resulted in the identification of 2,4,4-triphenylimidazoline (1), w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49f40a7f21c9f5ac3a1b6fc43ca2eff7
https://doi.org/10.1016/j.bmcl.2009.01.101
https://doi.org/10.1016/j.bmcl.2009.01.101
Autor:
Hisashi Iwaasa, Yoshikazu Nagae, Akio Kanatani, Tetsuya Kanno, Maki Kanesaka, Tomoyuki Ohe, Junko Ito, Minoru Moriya, Takehiro Fukami, Kenji Matsuda, Yuko Mitobe, Makoto Ishikawa, Yoshio Ogino, Akane Ishihara, Norikazu Ohtake
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4997-5001
Syntheses and structure-activity relationships of a novel class of 2-[3-oxospiro[isobenzofuran-1(3H),1'-cyclohexan]-4'-yl]benzimidazole NPY Y5 receptor antagonists are described. Optimization of the lead compound 2a by incorporating substituents into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c7b700b4ddf9680a2674ec427dc47ec
https://doi.org/10.1016/j.bmcl.2008.08.021
https://doi.org/10.1016/j.bmcl.2008.08.021
Autor:
Akio Kanatani, Lex H.T. Van der Ploeg, Akira Gomori, Toshiyuki Takahashi, Junko Ito, Akane Ishihara, Ryuichi Moriya, Hiroko Matsushita, Hidefumi Kitazawa, Satoshi Mashiko, Hisashi Iwaasa, Yuko Mitobe, Douglas J. MacNeil, Takehiro Fukami
Publikováno v:
Obesity. 16:1510-1515
Objective: To further address the function of the Y5 receptor in energy homeostasis, we investigated the effects of a novel spironolactone Y5 antagonist in diet-induced obese (DIO) mice. Methods and Procedures: Male C57BL/6 or Npy5r−/− mice were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88837af7b9c8206207e0da799c89f340
https://doi.org/10.1038/oby.2008.223
https://doi.org/10.1038/oby.2008.223
Autor:
Akane Ishihara, Akira Gomori, Masao Matsuda, Minoru Sasaki, Maria A. Bednarek, Douglas J. MacNeil, Masahiko Ito, Shigeharu Tsujioka, Hisashi Iwaasa, Akio Kanatani, Jun Suzuki, Makoto Ito
Publikováno v:
Journal of Endocrinology. 198:309-315
Blockade of brain melanin-concentrating hormone 1 receptor (MCH1R) significantly ameliorates fatty liver as well as obesity. However, the mode of action of this effect is unknown. This study examined the effect of a MCH1R antagonist in murine steatoh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e457fd6fcbf35800d084d669f0846d41
https://doi.org/10.1677/joe-08-0087
https://doi.org/10.1677/joe-08-0087
Autor:
Makoto Ito, Jun Suzuki, Takashi Shirakura, Akane Ishihara, Akira Gomori, Masahiko Ito, Hiroyasu Hirose, Hisashi Iwaasa, Minoru Sasaki, Akio Kanatani, Shigeharu Tsujioka
Publikováno v:
Hepatology Research. 37:50-57
Several lines of epidemiological evidence have suggested that non-alcoholic steatohepatitis (NASH) is closely associated with obesity in humans. However, the precise mechanisms of the progression of NASH and its key metabolic abnormalities remain to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a1b94b1db47fed4ed113604aca6e7fb
https://doi.org/10.1111/j.1872-034x.2007.00008.x
https://doi.org/10.1111/j.1872-034x.2007.00008.x
Autor:
Tetsuya Kanno, Nagaaki Sato, Toshiyuki Takahashi, Akio Kanatani, Aya Sakuraba, Hisashi Iwaasa, Tomoko Hirohashi, Takehiro Fukami, Takunobu Shibata, Masaaki Hirose, Katsumasa Nonoshita, Yuji Haga, Junko Ito
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:7501-7511
A series of phenylpiperazine derivatives were synthesized and evaluated for their neuropeptide Y (NPY) Y5 receptor antagonistic activities. The benzindane portion of 2 was replaced by 1-phenylpiperazine, resulting in novel urea derivative 3f. Subsequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60db73a33b6a2ab5ea27175a791d4d90
https://doi.org/10.1016/j.bmc.2006.07.023
https://doi.org/10.1016/j.bmc.2006.07.023
Autor:
Xiao-Ming Guan, Osamu Okamoto, Takahiro Fukuroda, Tomoyuki Ohe, Nagaaki Sato, Akira Gomori, Takehiro Fukami, Masaru Nishikibe, Yuko Mitobe, Hiroko Matsushita, Masaki Ihara, Lex M.T. Van Der Ploeg, Akio Kanatani, Naomi Murai, Hisashi Iwaasa, Masayasu Hidaka, Shin Ichiro Egashira, Takeshi Tanaka, Douglas J. MacNeil, Makoto Jitsuoka, Yasuyuki Ishii, Satoshi Mashiko, Akane Ishihara, Takashi Murai
Publikováno v:
Proceedings of the National Academy of Sciences. 103:7154-7158
Neuropeptide Y (NPY) is thought to have a major role in the physiological control of energy homeostasis. Among five NPY receptors described, the NPY Y5 receptor (Y5R) is a prime candidate to mediate some of the effects of NPY on energy homeostasis, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c396bd3e0ef862e30735347a3d9b593
https://doi.org/10.1073/pnas.0510320103
https://doi.org/10.1073/pnas.0510320103