Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Hisashi IKEGAMI"'
Autor:
Shun-ichiro Komatsu, Yoko Kayukawa, Yoko Miyazaki, Akihisa Kaneko, Hisashi Ikegami, Takahiro Ishiguro, Mikiko Nakamura, Werner Frings, Natsuki Ono, Kiyoaki Sakata, Toshihiko Fujii, Shohei Kishishita, Takehisa Kitazawa, Mika Endo, Yuji Sano
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Currently, ERY974, a humanized IgG4 bispecific T cell-redirecting antibody recognizing glypican-3 and CD3, is in phase I clinical trials. After a first-in-human clinical trial of an anti-CD28 agonist monoclonal antibody resulting in severe l
Externí odkaz:
https://doaj.org/article/d2beb88677cc4be395bfc5abeda0d963
Autor:
Shunsuke Nagao, Hitoshi Hagita, Shuichi Ohtomo, Yasuhiro Ichida, Manami Iida, Naoshi Horiba, Yoshinori Tsuboi, Kazuharu Ozawa, Tadakatsu Takahashi, Hisashi Ikegami
Publikováno v:
Kidney international. 98(2)
Chronic kidney disease is characterized as impaired renal function along with the imbalance and dysregulation of mineral metabolism; recognized as chronic kidney disease-mineral and bone disorder. Hyperphosphatemia, characterized by altered phosphate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b978064d3b55effc504de77f9d6c2cc4
https://pubmed.ncbi.nlm.nih.gov/32624180
https://pubmed.ncbi.nlm.nih.gov/32624180
Autor:
Kunio Doi, Hisashi Ikegami, Hiroyuki Nakayama, Hideaki Okamiya, Satoru Kajikawa, Kyoko Ito, Hisaki Miura
Publikováno v:
Journal of Toxicologic Pathology. 15:119-122
Fenoldopam, a dopaminergic (DA1) agonist, has been known to induce arteritis in the splanchnic arteries in rats by intravenous infusion. The arteritis was characterized by medial necrosis, hemorrhage, and endothelial hyperplasia in the acute phase an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af2036519cb56db07d31717b22e708ca
https://doi.org/10.1293/tox.15.119
https://doi.org/10.1293/tox.15.119
Autor:
Takanori Hanada, Katsuhiko Ishida, Kunio Doi, Takao Shishido, Hisashi Ikegami, Hiroyuki Nakayama
Publikováno v:
Experimental and Toxicologic Pathology. 53:25-30
Summary Fenoldopam, a dopaminergic (DA1) agonist, has been reported to induce medial necrosis and adventitial inflammatory response in the splanchnic arteries in rats. This study was carried out to clarify the detailed time course of the inflammatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfc9d1e6a33a2733634b16eff07cb278
https://doi.org/10.1078/0940-2993-00158
https://doi.org/10.1078/0940-2993-00158
Publikováno v:
The Journal of Toxicological Sciences. 25:137-142
The effect of insulin-induced hypoglycemia on spontaneous peripheral neuropathy in aged mice was examined. Ninety-five-week-old female B6C3F1 mice were infused subcutaneously for 2 weeks with 40 or 80 IU / kg / day of insulin with a micro osmotic pum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc0f47af4498707e1753898b7e8e22c
https://doi.org/10.2131/jts.25.137
https://doi.org/10.2131/jts.25.137
Autor:
Kyoko Ito, Hisashi Ikegami, Katsuhiko Ishida, Nami Nagamatsu, Ryutaro Okuda, Eiichi Nukui, Yutaka Fukuda, Kunio Doi
Publikováno v:
Journal of Toxicologic Pathology. 11:101-107
Male rats with fructose-induced hypertriglyceridemia become resistant to hepatotoxicity and more susceptible to nephrotoxicity of acetaminophen (APAP) as compared with normal male rats. To determine whether changes in APAP toxicity by fructose-treatm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b7128cb623b43dd84ce97648caa2bdc
https://doi.org/10.1293/tox.11.101
https://doi.org/10.1293/tox.11.101
Publikováno v:
Experimental and Toxicologic Pathology. 49:313-319
Summary Fructose-induced hypertriglyceridemic Sprague-Dawley (SD) rats become resistant to hepatotoxicity and susceptible to nephrotoxicity of acetaminophen (APAP) as compared with normal SD rats. Fischer-344 rats, which are susceptible to APAP nephr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceaf38f10cf6fccdde205e3d88b210d4
https://doi.org/10.1016/s0940-2993(97)80090-5
https://doi.org/10.1016/s0940-2993(97)80090-5
Publikováno v:
Experimental and Toxicologic Pathology. 49:321-327
Fructose-induced hypertriglyceridemic rats become resistant to hepatotoxicity and susceptible to nephrotoxicity of acetaminophen (APAP). Enhanced susceptibility to APAP nephrotoxicity in fructose-pretreated rats is due, at least in part, to increased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33d228f849a31c32602e2a95b6b4b1f9
https://doi.org/10.1016/s0940-2993(97)80093-0
https://doi.org/10.1016/s0940-2993(97)80093-0
Publikováno v:
Experimental and Toxicologic Pathology. 49:39-46
Summary Fructose-induced hypertriglyceridemic rats are resistant to hepatoxicity and susceptible to nephrotoxicity of acetaminophen (APAP) as compared with normal ones. The present studies were designed to evaluate how fructose-treatment affects the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d243ad98e90c1b4cc45de1be402b455
https://doi.org/10.1016/s0940-2993(97)80056-5
https://doi.org/10.1016/s0940-2993(97)80056-5
Autor:
Kensuke Myoujou, Hisashi Ikegami, Yui Suzuki, Chie Takada, Koji Saeki, Minami Imaizumi, Itaru Yamaguchi, Katsumi Takaba, Naoya Kimoto
Publikováno v:
The Journal of veterinary medical science. 74(1)
A 15-month-old male beagle dog used in a toxicity study had a primary renal mesenchymal tumor. Macroscopically, the tumor was a gray-white mass which was found in the right kidney, and extended from the capsule to a position slightly compressing the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa53a83ea288062d22b666a4aeef9170
https://pubmed.ncbi.nlm.nih.gov/21836376
https://pubmed.ncbi.nlm.nih.gov/21836376