Zobrazeno 1 - 10
of 293
pro vyhledávání: '"Hisashi HARADA"'
Autor:
Sofian Al Shboul, Mohammed El-Sadoni, Ahmad Alhesa, Nisreen Abu Shahin, Dua Abuquteish, Ola Abu Al Karsaneh, Elham Alsharaiah, Mohammad A. Ismail, Liliya Tyutyunyk-Massey, Moureq R. Alotaibi, Victoria Neely, Hisashi Harada, Tareq Saleh
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Neoadjuvant chemotherapy (NAC) is a frequently utilized approach to treat locally advanced breast cancer, but, unfortunately, a subset of tumors fails to undergo complete pathological response. Apoptosis and therapy-induced senescence (TIS)
Externí odkaz:
https://doaj.org/article/5d73956c379a445b81a893da313bf94f
Autor:
Abrar Softah, Moureq R. Alotaibi, Ali R. Alhoshani, Tareq Saleh, Khalid Alhazzani, Mashal M. Almutairi, Raed AlRowis, Samiyah Alshehri, Norah A. Albekairy, Hisashi Harada, Rowan Boyd, Eesha Chakraborty, David A. Gewirtz, Homood M. As Sobeai
Publikováno v:
Biomedicines, Vol 11, Iss 11, p 3066 (2023)
Despite significant advances in the treatment of triple-negative breast cancer, this disease continues to pose a clinical challenge, with many patients ultimately suffering from relapse. Tumor cells that recover after entering into a state of senesce
Externí odkaz:
https://doaj.org/article/96173029af474f86b34f9dc7633ce8a7
Autor:
Tareq Saleh, Valerie J. Carpenter, Liliya Tyutyunyk‐Massey, Graeme Murray, Joel D. Leverson, Andrew J. Souers, Moureq R. Alotaibi, Anthony C. Faber, Jason Reed, Hisashi Harada, David A. Gewirtz
Publikováno v:
Molecular Oncology, Vol 14, Iss 10, Pp 2504-2519 (2020)
Tumor cells undergo senescence in response to both conventional and targeted cancer therapies. The induction of senescence in response to cancer therapy can contribute to unfavorable patient outcomes, potentially including disease relapse. This possi
Externí odkaz:
https://doaj.org/article/b1ca93626c5148b4a9daf8f17d95e358
Publikováno v:
Frontiers in Oral Health, Vol 2 (2021)
Head and neck cancer is the sixth leading cancer worldwide; head and neck squamous cell carcinoma (HNSCC) accounts for more than 90% of incident cases. In the US, cases of HNSCC associated with human papillomavirus (HPV) have been growing in proporti
Externí odkaz:
https://doaj.org/article/e9615fc682994f2588d7f35faa44fd32
Autor:
Kanika Sharma, Thien‐Trang Vu, Wade Cook, Mitra Naseri, Kevin Zhan, Wataru Nakajima, Hisashi Harada
Publikováno v:
Molecular Oncology, Vol 12, Iss 6, Pp 788-798 (2018)
The platinum‐based DNA damaging agent cisplatin is used as a standard therapy for locally advanced head and neck squamous cell carcinoma (HNSCC). However, the mechanisms underpinning the cytotoxic effects of this compound are not entirely elucidate
Externí odkaz:
https://doaj.org/article/7a791fe7f3a3401db4ed6854af0fa9fb
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0219398 (2019)
The overall survival for recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) remains low, with little progress made over decades. Cisplatin, most frequently used for HNSCC treatment, activates mitochondria-dependent apoptosis throug
Externí odkaz:
https://doaj.org/article/b2f1a180fbe946e687bf95c179d1cb7d
Autor:
Anna V Miller, Mark A Hicks, Wataru Nakajima, Amanda C Richardson, Jolene J Windle, Hisashi Harada
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60685 (2013)
Paclitaxel (Taxol)-induced cell death requires the intrinsic cell death pathway, but the specific participants and the precise mechanisms are poorly understood. Previous studies indicate that a BH3-only protein BIM (BCL-2 Interacting Mediator of cell
Externí odkaz:
https://doaj.org/article/a3b43b60b7bc40f28676e7fe83daab48
Autor:
Hisashi, Harada
Publikováno v:
立教法学. 107:182-199
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=jairo_______::13d8c15098a2ece8329470aba8a168a9
http://id.nii.ac.jp/1062/00022288/
http://id.nii.ac.jp/1062/00022288/
Autor:
Anthony C. Faber, Cyril H. Benes, Mikhail G. Dozmorov, Devraj Basu, Iain M. Morgan, Yue Sun, Hisashi Harada, Jennifer E. Koblinski, Sosipatros A. Boikos, Maninderjit S. Ghotra, Krista M. Dalton, Patricia Greninger, Ellen Murchie, Regina K. Egan, Giovanna Stein Crowther, Rishabh Khatri, Colin M. Coon, Madhavi Puchalapalli, Bin Hu, Jinyang Cai, Ayesha T. Chawla, Sheeba Jacob, Konstantinos V. Floros, Richard Kurupi
Biological importance of Gab1 in HNSCC cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd1755ff52a1c2abd42395916bda423b
https://doi.org/10.1158/2767-9764.22545726.v1
https://doi.org/10.1158/2767-9764.22545726.v1
Autor:
Anthony C. Faber, Cyril H. Benes, Mikhail G. Dozmorov, Devraj Basu, Iain M. Morgan, Yue Sun, Hisashi Harada, Jennifer E. Koblinski, Sosipatros A. Boikos, Maninderjit S. Ghotra, Krista M. Dalton, Patricia Greninger, Ellen Murchie, Regina K. Egan, Giovanna Stein Crowther, Rishabh Khatri, Colin M. Coon, Madhavi Puchalapalli, Bin Hu, Jinyang Cai, Ayesha T. Chawla, Sheeba Jacob, Konstantinos V. Floros, Richard Kurupi
Preclinical and clinical studies have evidenced that effective targeted therapy treatment designed against receptor tyrosine kinases (RTKs) in different solid tumor paradigms is predicated on simultaneous inhibition of both the PI3K and MEK intracell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::024b6b35f0eff8644abf41336ecc088a
https://doi.org/10.1158/2767-9764.c.6551016.v1
https://doi.org/10.1158/2767-9764.c.6551016.v1