Zobrazeno 1 - 10
of 268
pro vyhledávání: '"Hisao Yamamura"'
Autor:
Kodai Yajima, Takeshi Akiyoshi, Kazuho Sakamoto, Yoshiaki Suzuki, Takayuki Oka, Ayuko Imaoka, Hisao Yamamura, Junko Kurokawa, Hisakazu Ohtani
Publikováno v:
Journal of Pharmacological Sciences, Vol 153, Iss 3, Pp 153-160 (2023)
Transporter-mediated clearance is determined by two factors, its single-molecule clearance, and expression level. However, no reliable method has been developed to evaluate them separately. This study aimed to develop a reliable method for evaluating
Externí odkaz:
https://doaj.org/article/c05ac3de23b04300a276f1cd40eb7de1
Autor:
Natsumi Shima, Aya Yamamura, Moe Fujiwara, Taiki Amano, Kazuyuki Matsumoto, Taiga Sekine, Haruka Okano, Rubii Kondo, Yoshiaki Suzuki, Hisao Yamamura
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
BackgroundPulmonary arterial hypertension (PAH) is a severe and rare disease in the cardiopulmonary system. Its pathogenesis involves vascular remodeling of the pulmonary artery, which results in progressive increases in pulmonary arterial pressure.
Externí odkaz:
https://doaj.org/article/64e8854dd74841dfb209206fd61743f7
Autor:
Masashi Ishida, Aya Yamamura, Moe Fujiwara, Taiki Amano, Mina Ota, Yukari Hikawa, Rubii Kondo, Yoshiaki Suzuki, Yuji Imaizumi, Hisao Yamamura
Publikováno v:
Journal of Pharmacological Sciences, Vol 153, Iss 2, Pp 84-88 (2023)
Pulmonary vessels play a pivotal role in oxygen circulation. We previously demonstrated that pimaric acid (PiMA) activated large-conductance Ca2+-activated K+ (BKCa) channels and inhibited voltage-dependent Ca2+ channels (VDCCs). In the present study
Externí odkaz:
https://doaj.org/article/0b91a9d114b945a9b6096be6f524e175
Publikováno v:
Journal of Pharmacological Sciences, Vol 151, Iss 2, Pp 119-127 (2023)
Pulmonary arterial hypertension (PAH) is a progressive and fatal disease that is characterized by vascular remodeling of the pulmonary artery. PAH remodeling is primarily caused by the excessive proliferation of pulmonary arterial smooth muscle cells
Externí odkaz:
https://doaj.org/article/b4bbf18595244c4b965cc13a2e035ff8
Publikováno v:
Journal of Pharmacological Sciences, Vol 148, Iss 3, Pp 286-294 (2022)
Activation of hepatic stellate cells (HSCs) causes hepatic fibrosis and results in chronic liver diseases. Although activated HSC functions are facilitated by an increase in the cytosolic Ca2+ concentration ([Ca2+]cyt), the pathophysiological roles o
Externí odkaz:
https://doaj.org/article/59b4613053314b55a6f42f717497ca93
Autor:
Akiko Kawade, Aya Yamamura, Moe Fujiwara, Saki Kobayashi, Shiho Mori, Chihiro Horii, Akari Hiraku, Sayo Suzumura, Kikuo Tsukamoto, Naoki Ohara, Rubii Kondo, Yoshiaki Suzuki, Hisao Yamamura
Publikováno v:
Journal of Pharmacological Sciences, Vol 147, Iss 1, Pp 81-85 (2021)
Pulmonary arterial hypertension (PAH) is a rare, progressive, and fatal cardiovascular/lung disease. The incidence rate is affected by age. Monocrotaline (MCT, 60 mg/kg)-treated rats are widely used as an experimental PAH model. Here, we found that y
Externí odkaz:
https://doaj.org/article/b2a81d9e1b344219b4f548fdd892030d
Publikováno v:
Journal of Pharmacological Sciences, Vol 146, Iss 1, Pp 65-69 (2021)
The blood–brain barrier (BBB) is mainly formed by brain capillary endothelial cells (BCECs) and is exposed to hypoxic environments under pathological conditions. The effects of hypoxia on the expression and activity of Ca2+-activated Cl− (ClCa) c
Externí odkaz:
https://doaj.org/article/4968c6615d40456fad391e34b64d3d94
Autor:
Rubii Kondo, Nami Furukawa, Akari Deguchi, Naoki Kawata, Yoshiaki Suzuki, Yuji Imaizumi, Hisao Yamamura
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Portal hypertension is defined as an increased pressure in the portal venous system and occurs as a major complication in chronic liver diseases. The pathological mechanism underlying the pathogenesis and development of portal hypertension has been e
Externí odkaz:
https://doaj.org/article/48722163b2bd461cb83465154de2f556
Autor:
Kazuho Sakamoto, Yoshiaki Suzuki, Hisao Yamamura, Susumu Ohya, Katsuhiko Muraki, Yuji Imaizumi
Publikováno v:
Journal of Pharmacological Sciences, Vol 133, Iss 4, Pp 223-231 (2017)
Voltage-gated K+ (KV) channels, which control firing and shape of action potentials in excitable cells, are supposed to be potential therapeutic targets in many types of diseases. Pimaric acid (PiMA) is a unique opener of large conductance Ca2+-activ
Externí odkaz:
https://doaj.org/article/592208facd274d0a83b6b62a18d1338d
Autor:
Toshiya Minakata, Akira Inagaki, Aya Yamamura, Hisao Yamamura, Shinji Sekiya, Shingo Murakami
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Maintaining Ca2+ homeostasis in lymphatic fluids is necessary for proper hearing. Despite its significance, the mechanisms that maintain the cochlear lymphatic Ca2+ concentrations within a certain range are not fully clarified. We investigated the fu
Externí odkaz:
https://doaj.org/article/18930d91d1ea41f9a3b4ad5f7791b4e3