Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Hisao Takayanagi"'
Autor:
Valluru Krishna Reddy, Kengo Aoshima, Nobuhisa Ozaki, Nao Kamikage, Mayumi Yamaoka, Gang Yu, Satoru Ito, Sophie Laurent, Mitsuji Yamashita, Manabu Yamada, Keita Kiyofuji, Michio Fujie, Harumi Sakahara, Satoki Nakamura, Luce Vander Elst, Junko Yamashita, Hisao Takayanagi, Kazuhide Asai, Kenji Tsunekawa, Yasuo Takehara, Takuya Suyama, Carmen Burtea, Reiko Makita, Keisuke Ogawa, Takashi Aoki, Robert N. Muller, Masaki Sugiyama
Publikováno v:
Advanced Materials Research. 222:217-220
Novel Sugar Dendritic Gd(III)-DTPA complexes for MRI Contrast Agents (CAs) were prepared and evaluated by in vitro and in vivo methods. The sugar dendritic MRI contrast agents had a good blood vessel pool character and drew blood vessels and liver ca
Autor:
Masaki Takahashi, Hisao Takayanagi, L. Vander Elst, Gang Yu, Kengo Aoshima, Mitsuji Yamashita, Robert N. Muller, Carmen Burtea, Sophie Laurent, Tatsuo Oshikawa
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:2246-2249
A new low-molecular weight dendrimer-like MRI contrast agent (Gd-D1) has been synthesized and characterized in vitro by proton and oxygen-17 relaxometry. Its pharmacokinetic parameters and biodistribution patterns were evaluated on rats. Its in vitro
Publikováno v:
J. Chem. Soc., Perkin Trans. 1. :751-756
A new ketal Claisen rearrangement using the ketal 10 for the isoprene unit elongation which affords terminal α-ketol terpenoid is presented. Its efficiency is demonstrated by successful transformation of the product of this reaction, the α-ketol 20
Autor:
Hisao Takayanagi
Publikováno v:
Journal of Synthetic Organic Chemistry, Japan. 53:724-736
The first total synthesis of sarcophytol A, an anticarcinogenic marine cembranoid, was achieved in a highly stereo- and enantioselective manner starting with (E, E)-farnesol ; it includes : 1) a newly developed Z-selective (Z : E=>35 : 1) Horner-Emmo
Publikováno v:
The Journal of Organic Chemistry. 59:2700-2706
A highly stereo- and enantioselective total synthesis of sarcophytol A (1), a marine cembranoid promising as a cancer chemopreventive agent, is described. The nitrile 10 obtained Z-selectively (Z:E=>35:1) by the Horner-Emmons reaction of (E,E)-farnes
Autor:
Hisao Takayanagi
Publikováno v:
Tetrahedron Letters. 35:1581-1584
Conditions which allow the Horner-Emmons reaction of phosphononitrile to proceed Z-selectively were clarified. The generality and usefulness of the procedure were demonstrated by an application to a stereoselective synthesis of plaunotol (9).
Autor:
Hisao Takayanagi, Yoshimasa Fukazawa, Yoshiyasu Fukuyama, Shinji Yamaguchi, Mitsuaki Kodama, Yasuhiro Morinaka, Shuji Usui, Suzuyo Yoshio
Publikováno v:
Tetrahedron Letters. 34:8453-8456
Both enantiomers of sarcophytols A (1) and T (2), cembranolide diterpenes isolated from a soft coral, were synthesized from a common chiral intermediate, obtained by baker's yeast reduction, using a stereospecific [2,3]Wittig rearrangement as the key
Publikováno v:
ChemInform. 23
(E)-9-Chloro-4-methyl-8-oxo-4-nonenoic acid, a useful intermediate in the synthesis of the potent antigestational agent ORF-13811 (a 3,8-dioxabicyclo[3.2.1]octane derivative), is efficiently prepared from 4-chloro-2-methyl-2-butene by using the ortho
Autor:
Hisao Takayanagi
Publikováno v:
ChemInform. 25
Conditions which allow the Horner-Emmons reaction of phosphononitrile to proceed Z-selectively were clarified. The generality and usefulness of the procedure were demonstrated by an application to a stereoselective synthesis of plaunotol (9).
Publikováno v:
ChemInform. 25
A highly stereo- and enantioselective total synthesis of sarcophytol A (1), a marine cembranoid promising as a cancer chemopreventive agent, is described. The nitrile 10 obtained Z-selectively (Z:E=>35:1) by the Horner-Emmons reaction of (E,E)-farnes