Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Hisao Saneyoshi"'
Autor:
Akira Ono, Hisao Saneyoshi
Publikováno v:
Journal of Synthetic Organic Chemistry, Japan. 78:886-893
Publikováno v:
Organic Letters. 22:6006-6009
Protection and deprotection of the 2'-hydroxyl group of RNAs are critical for RNA-based drug discovery. This paper reports development of a bioreduction labile protecting group of the 2'-hydroxyl group in RNA. After the reduction of the nitro group i
Autor:
Akira Ono, Hiroki Kanazawa, Hikari Ito, Misato Goto, Koudai Nakamura, Hisao Saneyoshi, Jiro Kondo
Publikováno v:
Angewandte Chemie. 131:16991-16994
Autor:
Hikari Ito, Jiro Kondo, Hisao Saneyoshi, Koudai Nakamura, Akira Ono, Hiroki Kanazawa, Misato Goto
Publikováno v:
Angewandte Chemie International Edition. 58:16835-16838
Numerous applications of metal-mediated base pairs (metallo-base-pairs) to nucleic acid based nanodevices and genetic code expansion have been extensively studied. Many of these metallo-base-pairs are formed in DNA and RNA duplexes containing Watson-
Publikováno v:
Current protocolsLiterature Cited. 1(9)
This protocol describes a method for the preparation of ribonucleoside phosphoramidite bearing a bioreductive protecting group on the 2'-OH group and its application in the synthesis of bioreduction-responsive oligonucleotides. The protecting group u
Publikováno v:
Organic Letters. 21:862-866
Glutathione-labile protecting groups for phosphodiester moieties in oligonucleotides were designed, synthesized, and incorporated into oligonucleotides. The protecting groups on the phosphodiester moieties were cleaved in a buffer containing 10 mM gl
Autor:
Jiro Kondo, Misato Goto, Takenori Dairaku, Takahiro Atsugi, Kohji Seio, Takahito Tomori, Akira Ono, Hisao Saneyoshi
Publikováno v:
RSC Advances. 9:22859-22862
Herein, we determined the crystal structure of a DNA duplex containing consecutive 6-thioguanine-6-thioguanine disulfides. The disulfide bonds were reversibly formed and cleaved in the presence of Cu(ii) ions and glutathione. To our knowledge, this i
Publikováno v:
Tetrahedron. 75:1-9
The elimination reaction of acrylonitrile from 2′-O-cyanoethylated nucleosides by Bu4NF was studied computationally. The transition structures for the reaction of 3-methoxypropionitrile with Me4NF were located at the MP2, B3LYP, and B3LYP-SCRF(Dipo
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(13)
Pro-fluorescent labeled oligonucleotides are potential alternative tools to classical fluorescently labeled oligonucleotides for monitoring cellular uptake. Here, we report the design and synthesis of a thiol-responsive pro-fluorophore labeled oligon
Autor:
Akira Ono, Hisao Saneyoshi
Publikováno v:
Chemical and Pharmaceutical Bulletin. 66:147-154
In recent years, nucleic acid-based drug therapeutics have gained considerable attention for their potential in the treatment of various diseases. However, their therapeutic value is greatly hindered by the challenge of delivering them into cells. On