Zobrazeno 1 - 10
of 208
pro vyhledávání: '"Hisao SEO"'
Publikováno v:
Journal of Molecular Endocrinology. 48:1-9
DHCR24encodes 3β-hydroxysteroid-Δ24 reductase, catalyzing the conversion of desmosterol to cholesterol. Our previous study demonstrated that DHCR24 exerts an anti-apoptotic function as a reactive oxygen species (ROS) scavenger, for which it needs i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c0a1ccfd0bb9daccf00b96630a7de7c
https://doi.org/10.1530/jme-11-0132
https://doi.org/10.1530/jme-11-0132
Publikováno v:
Journal of Bone and Mineral Metabolism. 30:144-153
Desmosterolosis is an autosomal recessive disease caused by mutations in the 3β-hydroxysterol-Delta24 reductase (DHCR24) gene, with severe developmental anomalies including short limbs. We utilized DHCR24 knockout (KO) mice to study the underlying b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a496027553144abb33c4e5aa4efc749
https://doi.org/10.1007/s00774-011-0303-7
https://doi.org/10.1007/s00774-011-0303-7
Publikováno v:
Biochemical Journal. 424:201-209
We have reported previously a non-genomic action of T3 (3,3',5-tri-iodothyronine), which stimulates the PI3K (phosphoinositide 3-kinase)/Akt pathway via p85alpha, the regulatory subunit of PI3K, in human skin fibroblasts. The aim of the present study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c01b230289f6e5b9ca68aa6b0b439ae
https://doi.org/10.1042/bj20090643
https://doi.org/10.1042/bj20090643
Publikováno v:
Molecular Endocrinology. 22:893-903
AMP-activated protein kinase (AMPK) is a key regulator of glucose and fatty acid homeostasis. In muscle cells, AMPK stimulates mitochondrial fatty acid oxidation and ATP production. The thyroid hormone T3 increases cellular oxygen consumption and is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f121f6cf3010a7658873738277b9287
https://doi.org/10.1210/me.2007-0249
https://doi.org/10.1210/me.2007-0249
Autor:
Hisao Seo, K. Maki, Takahide Kaji, Rusella Mirza, Yoshiharu Murata, Shizu Hayasaka, Fukushi Kambe
Publikováno v:
British Journal of Dermatology. 158:679-684
Summary Background The DHCR24 (3β-hydroxysterol-Δ24 reductase) gene encodes an enzyme catalysing conversion of desmosterol to cholesterol. Desmosterolosis is an autosomal recessive disease due to mutation in the DHCR24 gene, with low cholesterol an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::530c8b3be6100cfd3853504c202431f9
https://doi.org/10.1111/j.1365-2133.2007.08424.x
https://doi.org/10.1111/j.1365-2133.2007.08424.x
Publikováno v:
Endocrinology. 149:3267-3273
3beta-Hydroxysteroid-Delta24 reductase (DHCR24) is an endoplasmic reticulum-resident, multifunctional enzyme that possesses antiapoptotic and cholesterol-synthesizing activities. To clarify the molecular basis of the former activity, we investigated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe8703378fb5d06cb9302f549fe45c1d
https://doi.org/10.1210/en.2008-0024
https://doi.org/10.1210/en.2008-0024
Autor:
Yoshiharu Murata, Masamichi Ogawa, John A. Phillips, Yoshitaka Hayashi, Hisao Seo, Takashi Kamijo, Michiyo Yamamoto
Publikováno v:
Growth Hormone & IGF Research. 17:249-253
Objective To characterize the cause of a sporadic isolated growth hormone deficiency in a single patient. Methods Genomic DNA was extracted from blood samples of the patient and his family. Exons and exon–intron junctions of the GH-1 gene were ampl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::167a578a1ae2e37460e5ad4df844309a
https://doi.org/10.1016/j.ghir.2007.01.019
https://doi.org/10.1016/j.ghir.2007.01.019
Autor:
Yutaka Ishihara, Takami Inoue, Naohito Yamamoto, Yutaka Tomoda, Nobuo Matsui, Fumitaka Kikkawa, Tetsuya Mizutani, Hisao Seo, Osamu Narita, Nobuhiko Suganuma, Hisanori Oguri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::113976b960a309b153e507bb19337cb6
https://doi.org/10.1159/000416258
https://doi.org/10.1159/000416258
Publikováno v:
Current Opinion in Endocrinology and Diabetes. 13:439-443
Purpose of reviewA nongenomic action that does not directly and initially influence gene expression but rather causes a rapid effect such as activation of signaling cascades, has been recently described. The involvement of a thyroid hormone receptor,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70fa33bcbcfb9569e6bc4bfa575e9a0c
https://doi.org/10.1097/01.med.0000244226.83657.39
https://doi.org/10.1097/01.med.0000244226.83657.39
Autor:
Toyone Kikumori, Hironobu Kobayashi, Yatsuka Hibi, Fukushi Kambe, Akimasa Nakao, Hisao Seo, Tsuneo Imai, Sachiko Ohmori
Publikováno v:
Journal of Endocrinology. 189:671-679
An important role for the cyclin-dependent kinase inhibitors (CDKIs), p27Kip1 and p57Kip2, in the proliferation and differentiation of adrenal cells has been suggested by their knockout mice, which display adrenal hyperplasia. Adrenal development and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f3a2fcffdddca0f38b0195a3c6cd62a
https://doi.org/10.1677/joe.1.06419
https://doi.org/10.1677/joe.1.06419