Výsledky vyhledávání - "Hisao Minato"

Effect of OS-0689, a novel SERM, on periarterial nerve function in tail arteries of ovariectomized rats

Autor: Nobuhide Watanabe, Akihisa Ikeno, Hisao Minato, Jun-ichi Tsuji

Publikováno v: Maturitas. 51:434-441

Objective: We have previously shown that OS-0689 attenuates the rise in tail skin temperature of ovariectomized rats, which is believed to be relevant to human symptoms of hot flush. In this study, we elucidate the mechanism underlying the ameliorati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a92bc741572b85f37523bb572e7c52cd
https://doi.org/10.1016/j.maturitas.2004.11.003

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Novel and orally bioavailable inducible nitric oxide synthase inhibitors: synthesis and evaluation of optically active 4,5-dialkyl-2-iminoselenazolidine derivatives

Autor: Kenji Suzuki, Shigeo Ueda, Akihiro Yano, Jun-ichi Tsuji, Taeko Kubo, Yukiyo Arai, Hideo Terauchi, Hisao Minato, Masashi Matsumoto, Nobuhide Watanabe

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 15:1361-1366

We have previously reported that (4R,5R)-5-ethyl-2-imino-4-methylthiazolidine (3) strongly inhibits inducible nitric oxide synthase (iNOS). In a successive search for strong and selective iNOS inhibitors, we, herein, describe the synthesis of the sel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34942c6636de3dfcd658479cf69744cc
https://doi.org/10.1016/j.bmcl.2005.01.013

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4-(4-Alkylpiperazin-1-yl)phenyl group: A novel class of basic side chains for selective estrogen receptor modulators

Autor: Hisao Minato, Jun-ichi Tsuji, Nobuhide Watanabe, Akihisa Ikeno, Hiroshi Nakagawa, Chie Kohayakawa

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 13:4317-4320

In the structure-activity relationships of spiro[indene-1,1'-indane] series, the 4-(4-alkylpiperazin-1-yl)phenyl group was found to be functionally equipotent to the 4-(1-piperidinoethoxy)phenyl group, the most widely used basic side chain in selecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::735a8907783d217f70c81321bbf90258
https://doi.org/10.1016/j.bmcl.2003.09.049

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Discovery and Preclinical Characterization of (+)-3-[4-(1- Piperidinoethoxy)phenyl]spiro[indene- 1,1‘-indane]-5,5‘-diol Hydrochloride: A Promising Nonsteroidal Estrogen Receptor Agonist for Hot Flush

Autor: Akihisa Ikeno, Chie Kohayakawa, Hiroshi Nakagawa, Nobuhide Watanabe, Hisao Minato, Jun-ichi Tsuji

Publikováno v: Journal of Medicinal Chemistry. 46:3961-3964

In our studies of the development of a novel class of selective estrogen receptor modulators, (+)-3-[4-(1-piperidinoethoxy)phenyl]spiro[indene-1,1'-indane]-5,5'-diol hydrochloride (1) was found to be an estrogen receptor ligand with beneficial effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d14c62154caa70c52f5cbbbbb66029da
https://doi.org/10.1021/jm034134+

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Effect of OS-0544, a selective estrogen receptor modulator, on endothelial function and increased sympathetic activity in ovariectomized rats

Autor: Hisao Minato, Chie Kohayakawa, Jun-ichi Tsuji, Akihisa Ikeno

Publikováno v: Vascular pharmacology. 50(1-2)

Estrogens are known to contribute to endothelial function and sympathetic activity, both of which are strongly associated with the pathogenesis of ischemic heart disease. In addition, estrogens improve impaired lipid profile, a risk factor of endothe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e70b0b9530e6e9165430caaab62dbec
https://pubmed.ncbi.nlm.nih.gov/18854227

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Effects of monatepil maleate, a new Ca2+ channel antagonist with alpha1-adrenoceptor antagonistic activity, on cholesterol absorption and catabolism in high cholesterol diet-fed rabbits

Autor: Toshiki Sumiya, Masuo Kurono, Akihisa Ikeno, Yoshinobu Masuda, Masashi Yasuba, Kanoo Hosoki, Hisao Minato, Buichi Fujitani

Publikováno v: Japanese journal of pharmacology. 78(3)

The mechanism of the prophylactic effect against hyperlipidemia by monatepil maleate was investigated in animal models. Monatepil maleate is an antihypertensive agent with Ca2+-channel antagonistic, alpha1-adrenergic receptor-blocking, and lipid pero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7e855e9071a531e551f8d691c1bc6b8
https://pubmed.ncbi.nlm.nih.gov/9869264

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Protective effect of zonisamide, an antiepileptic drug, against transient focal cerebral ischemia with middle cerebral artery occlusion-reperfusion in rats

Autor: Chie Kikuta, Buichi Fujitani, Hisao Minato, Yoshinobu Masuda

Publikováno v: Epilepsia. 38(9)

Summary: Purpose: The antiepileptic effects of zonisamide (ZNS) have been well documented experimentally and clinically. The purpose of this study was to examine whether ZNS reduces cerebral damage after transient focal ischemia in rats. Methods: Isc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dfbed15d69a48894dfd0971ef70fc6e
https://pubmed.ncbi.nlm.nih.gov/9579935

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Prevention by the new Ca2+ channel antagonist, AJ-3941, of loss of endothelium-dependent relaxation after subarachnoid hemorrhage in rats

Autor: Buichi Fujitani, Yoshinobu Masuda, Hisao Minato, Kanoo Hosoki, Yayoi Honda

Publikováno v: European journal of pharmacology. 315(3)

AJ-3941 ((+/-)-(E)-1-(3-fluoro-6,11-dihydrodibenz[b,e]-oxepine-11-yl ) -4-(3-phenyl-2-propenyl)-piperazine dimaleate; CAS No. 143110-70-7), a cerebrovascular-selective Ca2+ channel antagonist having anti-lipid peroxidative action, was reported to pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27d83576375884b3f82051fbb52461d
https://pubmed.ncbi.nlm.nih.gov/8982668

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